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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP2B1
Full Name:
Plasma membrane calcium-transporting ATPase 1
Alias:
AT2B1; ATPase, Ca++ transporting, plasma membrane 1; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1
Type:
Membrane protein, integral; Transporter; EC 3.6.3.8; Hydrolase
Mass (Da):
138755
Number AA:
1258
UniProt ID:
P20020
International Prot ID:
IPI00216526
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005509
GO:0005388
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0006816
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
G
D
M
A
N
N
S
V
A
Y
S
G
V
K
Site 2
S12
A
N
N
S
V
A
Y
S
G
V
K
N
S
L
K
Site 3
S17
A
Y
S
G
V
K
N
S
L
K
E
A
N
H
D
Site 4
T30
H
D
G
D
F
G
I
T
L
A
E
L
R
A
L
Site 5
S42
R
A
L
M
E
L
R
S
T
D
A
L
R
K
I
Site 6
T43
A
L
M
E
L
R
S
T
D
A
L
R
K
I
Q
Site 7
S52
A
L
R
K
I
Q
E
S
Y
G
D
V
Y
G
I
Site 8
Y53
L
R
K
I
Q
E
S
Y
G
D
V
Y
G
I
C
Site 9
Y57
Q
E
S
Y
G
D
V
Y
G
I
C
T
K
L
K
Site 10
T65
G
I
C
T
K
L
K
T
S
P
N
E
G
L
S
Site 11
S66
I
C
T
K
L
K
T
S
P
N
E
G
L
S
G
Site 12
S72
T
S
P
N
E
G
L
S
G
N
P
A
D
L
E
Site 13
T97
I
P
P
K
K
P
K
T
F
L
Q
L
V
W
E
Site 14
Y127
V
S
L
G
L
S
F
Y
Q
P
P
E
G
D
N
Site 15
S141
N
A
L
C
G
E
V
S
V
G
E
E
E
G
E
Site 16
T195
I
E
Q
E
Q
K
F
T
V
I
R
G
G
Q
V
Site 17
Y220
G
D
I
A
Q
V
K
Y
G
D
L
L
P
A
D
Site 18
S241
N
D
L
K
I
D
E
S
S
L
T
G
E
S
D
Site 19
S242
D
L
K
I
D
E
S
S
L
T
G
E
S
D
H
Site 20
T244
K
I
D
E
S
S
L
T
G
E
S
D
H
V
K
Site 21
S247
E
S
S
L
T
G
E
S
D
H
V
K
K
S
L
Site 22
S253
E
S
D
H
V
K
K
S
L
D
K
D
P
L
L
Site 23
S262
D
K
D
P
L
L
L
S
G
T
H
V
M
E
G
Site 24
T276
G
S
G
R
M
V
V
T
A
V
G
V
N
S
Q
Site 25
S282
V
T
A
V
G
V
N
S
Q
T
G
I
I
F
T
Site 26
T289
S
Q
T
G
I
I
F
T
L
L
G
A
G
G
E
Site 27
S338
M
E
M
Q
P
L
K
S
E
E
G
G
D
G
D
Site 28
S360
N
L
P
K
K
E
K
S
V
L
Q
G
K
L
T
Site 29
T425
K
F
F
I
I
G
V
T
V
L
V
V
A
V
P
Site 30
Y445
A
V
T
I
S
L
A
Y
S
V
K
K
M
M
K
Site 31
S446
V
T
I
S
L
A
Y
S
V
K
K
M
M
K
D
Site 32
T477
T
A
I
C
S
D
K
T
G
T
L
T
M
N
R
Site 33
T481
S
D
K
T
G
T
L
T
M
N
R
M
T
V
V
Site 34
T545
P
R
H
V
G
N
K
T
E
C
A
L
L
G
L
Site 35
Y560
L
L
D
L
K
R
D
Y
Q
D
V
R
N
E
I
Site 36
Y573
E
I
P
E
E
A
L
Y
K
V
Y
T
F
N
S
Site 37
T577
E
A
L
Y
K
V
Y
T
F
N
S
V
R
K
S
Site 38
S580
Y
K
V
Y
T
F
N
S
V
R
K
S
M
S
T
Site 39
S584
T
F
N
S
V
R
K
S
M
S
T
V
L
K
N
Site 40
S586
N
S
V
R
K
S
M
S
T
V
L
K
N
S
D
Site 41
T587
S
V
R
K
S
M
S
T
V
L
K
N
S
D
G
Site 42
S595
V
L
K
N
S
D
G
S
Y
R
I
F
S
K
G
Site 43
Y596
L
K
N
S
D
G
S
Y
R
I
F
S
K
G
A
Site 44
S600
D
G
S
Y
R
I
F
S
K
G
A
S
E
I
I
Site 45
S616
K
K
C
F
K
I
L
S
A
N
G
E
A
K
V
Site 46
T635
D
R
D
D
I
V
K
T
V
I
E
P
M
A
S
Site 47
T703
K
C
Q
R
A
G
I
T
V
R
M
V
T
G
D
Site 48
S768
K
L
R
V
L
A
R
S
S
P
T
D
K
H
T
Site 49
S769
L
R
V
L
A
R
S
S
P
T
D
K
H
T
L
Site 50
T775
S
S
P
T
D
K
H
T
L
V
K
G
I
I
D
Site 51
S783
L
V
K
G
I
I
D
S
T
V
S
D
Q
R
Q
Site 52
T784
V
K
G
I
I
D
S
T
V
S
D
Q
R
Q
V
Site 53
T795
Q
R
Q
V
V
A
V
T
G
D
G
T
N
D
G
Site 54
T831
E
A
S
D
I
I
L
T
D
D
N
F
T
S
I
Site 55
Y849
V
M
W
G
R
N
V
Y
D
S
I
S
K
F
L
Site 56
S853
R
N
V
Y
D
S
I
S
K
F
L
Q
F
Q
L
Site 57
S899
L
I
M
D
T
L
A
S
L
A
L
A
T
E
P
Site 58
T908
A
L
A
T
E
P
P
T
E
S
L
L
L
R
K
Site 59
Y917
S
L
L
L
R
K
P
Y
G
R
N
K
P
L
I
Site 60
S958
E
K
F
F
D
I
D
S
G
R
N
A
P
L
H
Site 61
S1032
Q
F
G
G
K
P
F
S
C
S
E
L
S
I
E
Site 62
S1034
G
G
K
P
F
S
C
S
E
L
S
I
E
Q
W
Site 63
T1116
R
G
L
N
R
I
Q
T
Q
M
D
V
V
N
A
Site 64
S1126
D
V
V
N
A
F
Q
S
G
S
S
I
Q
G
A
Site 65
S1128
V
N
A
F
Q
S
G
S
S
I
Q
G
A
L
R
Site 66
S1129
N
A
F
Q
S
G
S
S
I
Q
G
A
L
R
R
Site 67
S1139
G
A
L
R
R
Q
P
S
I
A
S
Q
H
H
D
Site 68
T1148
A
S
Q
H
H
D
V
T
N
I
S
T
P
T
H
Site 69
T1152
H
D
V
T
N
I
S
T
P
T
H
I
R
V
V
Site 70
S1164
R
V
V
N
A
F
R
S
S
L
Y
E
G
L
E
Site 71
S1165
V
V
N
A
F
R
S
S
L
Y
E
G
L
E
K
Site 72
Y1167
N
A
F
R
S
S
L
Y
E
G
L
E
K
P
E
Site 73
S1175
E
G
L
E
K
P
E
S
R
S
S
I
H
N
F
Site 74
S1177
L
E
K
P
E
S
R
S
S
I
H
N
F
M
T
Site 75
S1178
E
K
P
E
S
R
S
S
I
H
N
F
M
T
H
Site 76
T1184
S
S
I
H
N
F
M
T
H
P
E
F
R
I
E
Site 77
S1193
P
E
F
R
I
E
D
S
E
P
H
I
P
L
I
Site 78
T1203
H
I
P
L
I
D
D
T
D
A
E
D
D
A
P
Site 79
T1211
D
A
E
D
D
A
P
T
K
R
N
S
S
P
P
Site 80
S1215
D
A
P
T
K
R
N
S
S
P
P
P
S
P
N
Site 81
S1216
A
P
T
K
R
N
S
S
P
P
P
S
P
N
K
Site 82
S1220
R
N
S
S
P
P
P
S
P
N
K
N
N
N
A
Site 83
S1241
L
T
I
E
M
N
K
S
A
T
S
S
S
P
G
Site 84
S1244
E
M
N
K
S
A
T
S
S
S
P
G
S
P
L
Site 85
S1245
M
N
K
S
A
T
S
S
S
P
G
S
P
L
H
Site 86
S1246
N
K
S
A
T
S
S
S
P
G
S
P
L
H
S
Site 87
S1249
A
T
S
S
S
P
G
S
P
L
H
S
L
E
T
Site 88
S1253
S
P
G
S
P
L
H
S
L
E
T
S
L
_
_
Site 89
T1256
S
P
L
H
S
L
E
T
S
L
_
_
_
_
_
Site 90
S1257
P
L
H
S
L
E
T
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation