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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CEL
Full Name:
Bile salt-activated lipase
Alias:
Bile salt-stimulated lipase;Bucelipase;Carboxyl ester lipase;Cholesterol esterase;Pancreatic lysophospholipase;Sterol esterase
Type:
Mass (Da):
79322
Number AA:
753
UniProt ID:
P19835
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T74
P
H
P
G
W
Q
G
T
L
K
A
K
N
F
K
Site 2
T88
K
K
R
C
L
Q
A
T
I
T
Q
D
S
T
Y
Site 3
T90
R
C
L
Q
A
T
I
T
Q
D
S
T
Y
G
D
Site 4
T94
A
T
I
T
Q
D
S
T
Y
G
D
E
D
C
L
Site 5
Y95
T
I
T
Q
D
S
T
Y
G
D
E
D
C
L
Y
Site 6
Y102
Y
G
D
E
D
C
L
Y
L
N
I
W
V
P
Q
Site 7
Y143
G
A
N
F
L
N
N
Y
L
Y
D
G
E
E
I
Site 8
Y145
N
F
L
N
N
Y
L
Y
D
G
E
E
I
A
T
Site 9
T209
G
G
D
P
N
N
I
T
L
F
G
E
S
A
G
Site 10
T224
G
A
S
V
S
L
Q
T
L
S
P
Y
N
K
G
Site 11
S226
S
V
S
L
Q
T
L
S
P
Y
N
K
G
L
I
Site 12
Y228
S
L
Q
T
L
S
P
Y
N
K
G
L
I
R
R
Site 13
S238
G
L
I
R
R
A
I
S
Q
S
G
V
A
L
S
Site 14
S240
I
R
R
A
I
S
Q
S
G
V
A
L
S
P
W
Site 15
S245
S
Q
S
G
V
A
L
S
P
W
V
I
Q
K
N
Site 16
Y324
P
A
D
P
I
N
L
Y
A
N
A
A
D
I
D
Site 17
Y332
A
N
A
A
D
I
D
Y
I
A
G
T
N
N
M
Site 18
Y365
K
V
T
E
E
D
F
Y
K
L
V
S
E
F
T
Site 19
T382
K
G
L
R
G
A
K
T
T
F
D
V
Y
T
E
Site 20
T383
G
L
R
G
A
K
T
T
F
D
V
Y
T
E
S
Site 21
Y387
A
K
T
T
F
D
V
Y
T
E
S
W
A
Q
D
Site 22
T388
K
T
T
F
D
V
Y
T
E
S
W
A
Q
D
P
Site 23
S390
T
F
D
V
Y
T
E
S
W
A
Q
D
P
S
Q
Site 24
S396
E
S
W
A
Q
D
P
S
Q
E
N
K
K
K
T
Site 25
T403
S
Q
E
N
K
K
K
T
V
V
D
F
E
T
D
Site 26
S430
Q
H
R
A
N
A
K
S
A
K
T
Y
A
Y
L
Site 27
Y434
N
A
K
S
A
K
T
Y
A
Y
L
F
S
H
P
Site 28
Y436
K
S
A
K
T
Y
A
Y
L
F
S
H
P
S
R
Site 29
S439
K
T
Y
A
Y
L
F
S
H
P
S
R
M
P
V
Site 30
S442
A
Y
L
F
S
H
P
S
R
M
P
V
Y
P
K
Site 31
Y447
H
P
S
R
M
P
V
Y
P
K
W
V
G
A
D
Site 32
Y461
D
H
A
D
D
I
Q
Y
V
F
G
K
P
F
A
Site 33
T469
V
F
G
K
P
F
A
T
P
T
G
Y
R
P
Q
Site 34
T471
G
K
P
F
A
T
P
T
G
Y
R
P
Q
D
R
Site 35
T479
G
Y
R
P
Q
D
R
T
V
S
K
A
M
I
A
Site 36
S502
G
D
P
N
M
G
D
S
A
V
P
T
H
W
E
Site 37
T506
M
G
D
S
A
V
P
T
H
W
E
P
Y
T
T
Site 38
T512
P
T
H
W
E
P
Y
T
T
E
N
S
G
Y
L
Site 39
T513
T
H
W
E
P
Y
T
T
E
N
S
G
Y
L
E
Site 40
Y518
Y
T
T
E
N
S
G
Y
L
E
I
T
K
K
M
Site 41
T522
N
S
G
Y
L
E
I
T
K
K
M
G
S
S
S
Site 42
S527
E
I
T
K
K
M
G
S
S
S
M
K
R
S
L
Site 43
S529
T
K
K
M
G
S
S
S
M
K
R
S
L
R
T
Site 44
S533
G
S
S
S
M
K
R
S
L
R
T
N
F
L
R
Site 45
T558
T
V
T
D
Q
E
A
T
P
V
P
P
T
G
D
Site 46
T569
P
T
G
D
S
E
A
T
P
V
P
P
T
G
D
Site 47
T579
P
P
T
G
D
S
E
T
A
P
V
P
P
T
G
Site 48
S588
P
V
P
P
T
G
D
S
G
A
P
P
V
P
P
Site 49
T596
G
A
P
P
V
P
P
T
G
D
S
G
A
P
P
Site 50
T673
G
A
P
P
V
P
P
T
G
D
A
G
P
P
P
Site 51
T684
G
P
P
P
V
P
P
T
G
D
S
G
A
P
P
Site 52
S698
P
V
P
P
T
G
D
S
G
A
P
P
V
T
P
Site 53
T704
D
S
G
A
P
P
V
T
P
T
G
D
S
E
T
Site 54
S709
P
V
T
P
T
G
D
S
E
T
A
P
V
P
P
Site 55
T711
T
P
T
G
D
S
E
T
A
P
V
P
P
T
G
Site 56
T728
G
A
P
P
V
P
P
T
G
D
S
E
A
A
P
Site 57
T739
E
A
A
P
V
P
P
T
D
D
S
K
E
A
Q
Site 58
S742
P
V
P
P
T
D
D
S
K
E
A
Q
M
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation