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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ITIH1
Full Name:
Inter-alpha-trypsin inhibitor heavy chain H1
Alias:
H1P; IATIH; IGHEP1; Inter-alpha (globulin) inhibitor H1; Inter-alpha-inhibitor heavy chain 1; Inter-alpha-trypsin inhibitor complex component III; Inter-alpha-trypsin inhibitor heavy chain H1 precursor; ITI heavy chain H1; ITIH; Serum-derived hyaluronan-associated protein; SHAP
Type:
Inhibitor protein
Mass (Da):
101389
Number AA:
911
UniProt ID:
P19827
International Prot ID:
IPI00292530
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0030212
GO:0045321
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
Q
A
M
P
A
L
G
S
A
T
G
R
S
K
S
Site 2
T32
M
P
A
L
G
S
A
T
G
R
S
K
S
S
E
Site 3
S37
S
A
T
G
R
S
K
S
S
E
K
R
Q
A
V
Site 4
S38
A
T
G
R
S
K
S
S
E
K
R
Q
A
V
D
Site 5
T46
E
K
R
Q
A
V
D
T
A
V
D
G
V
F
I
Site 6
T118
G
D
I
K
D
K
V
T
A
W
K
Q
Y
R
K
Site 7
S129
Q
Y
R
K
A
A
I
S
G
E
N
A
G
L
V
Site 8
S139
N
A
G
L
V
R
A
S
G
R
T
M
E
Q
F
Site 9
T142
L
V
R
A
S
G
R
T
M
E
Q
F
T
I
H
Site 10
T151
E
Q
F
T
I
H
L
T
V
N
P
Q
S
K
V
Site 11
S156
H
L
T
V
N
P
Q
S
K
V
T
F
Q
L
T
Site 12
T163
S
K
V
T
F
Q
L
T
Y
E
E
V
L
K
R
Site 13
Y175
L
K
R
N
H
M
Q
Y
E
I
V
I
K
V
K
Site 14
S210
S
K
L
D
A
Q
A
S
F
L
P
K
E
L
A
Site 15
T220
P
K
E
L
A
A
Q
T
I
K
K
S
F
S
G
Site 16
S224
A
A
Q
T
I
K
K
S
F
S
G
K
K
G
H
Site 17
S226
Q
T
I
K
K
S
F
S
G
K
K
G
H
V
L
Site 18
T237
G
H
V
L
F
R
P
T
V
S
Q
Q
Q
S
C
Site 19
S239
V
L
F
R
P
T
V
S
Q
Q
Q
S
C
P
T
Site 20
S243
P
T
V
S
Q
Q
Q
S
C
P
T
C
S
T
S
Site 21
T246
S
Q
Q
Q
S
C
P
T
C
S
T
S
L
L
N
Site 22
S250
S
C
P
T
C
S
T
S
L
L
N
G
H
F
K
Site 23
T259
L
N
G
H
F
K
V
T
Y
D
V
S
R
D
K
Site 24
Y260
N
G
H
F
K
V
T
Y
D
V
S
R
D
K
I
Site 25
S302
F
V
I
D
I
S
G
S
M
R
G
Q
K
V
K
Site 26
Y327
G
D
M
Q
P
G
D
Y
F
D
L
V
L
F
G
Site 27
S339
L
F
G
T
R
V
Q
S
W
K
G
S
L
V
Q
Site 28
S343
R
V
Q
S
W
K
G
S
L
V
Q
A
S
E
A
Site 29
S363
Q
D
F
V
R
G
F
S
L
D
E
A
T
N
L
Site 30
S387
I
L
N
Q
V
Q
E
S
L
P
E
L
S
N
H
Site 31
S392
Q
E
S
L
P
E
L
S
N
H
A
S
I
L
I
Site 32
T402
A
S
I
L
I
M
L
T
D
G
D
P
T
E
G
Site 33
T407
M
L
T
D
G
D
P
T
E
G
V
T
D
R
S
Site 34
S414
T
E
G
V
T
D
R
S
Q
I
L
K
N
V
R
Site 35
Y431
I
R
G
R
F
P
L
Y
N
L
G
F
G
H
N
Site 36
Y459
N
G
R
A
Q
R
I
Y
E
D
H
D
A
T
Q
Site 37
S473
Q
Q
L
Q
G
F
Y
S
Q
V
A
K
P
L
L
Site 38
Y503
T
Q
N
H
H
K
Q
Y
Y
E
G
S
E
I
V
Site 39
S522
I
A
D
N
K
Q
S
S
F
K
A
D
V
Q
A
Site 40
S537
H
G
E
G
Q
E
F
S
I
T
C
L
V
D
E
Site 41
T539
E
G
Q
E
F
S
I
T
C
L
V
D
E
E
E
Site 42
S590
R
E
E
R
A
N
L
S
S
Q
A
L
Q
M
S
Site 43
S591
E
E
R
A
N
L
S
S
Q
A
L
Q
M
S
L
Site 44
S610
V
T
P
L
T
S
M
S
I
R
G
M
A
D
Q
Site 45
S628
K
P
T
I
D
K
P
S
E
D
S
P
P
L
E
Site 46
S631
I
D
K
P
S
E
D
S
P
P
L
E
M
L
G
Site 47
S646
P
R
R
T
F
V
L
S
A
L
Q
P
S
P
T
Site 48
S651
V
L
S
A
L
Q
P
S
P
T
H
S
S
S
N
Site 49
T653
S
A
L
Q
P
S
P
T
H
S
S
S
N
T
Q
Site 50
S655
L
Q
P
S
P
T
H
S
S
S
N
T
Q
R
L
Site 51
S657
P
S
P
T
H
S
S
S
N
T
Q
R
L
P
D
Site 52
T659
P
T
H
S
S
S
N
T
Q
R
L
P
D
R
V
Site 53
T667
Q
R
L
P
D
R
V
T
G
V
D
T
D
P
H
Site 54
T671
D
R
V
T
G
V
D
T
D
P
H
F
I
I
H
Site 55
T685
H
V
P
Q
K
E
D
T
L
C
F
N
I
N
E
Site 56
S699
E
E
P
G
V
I
L
S
L
V
Q
D
P
N
T
Site 57
T706
S
L
V
Q
D
P
N
T
G
F
S
V
N
G
Q
Site 58
S709
Q
D
P
N
T
G
F
S
V
N
G
Q
L
I
G
Site 59
S721
L
I
G
N
K
A
R
S
P
G
Q
H
D
G
T
Site 60
T728
S
P
G
Q
H
D
G
T
Y
F
G
R
L
G
I
Site 61
Y729
P
G
Q
H
D
G
T
Y
F
G
R
L
G
I
A
Site 62
T747
T
D
F
Q
L
E
V
T
P
Q
N
I
T
L
N
Site 63
T752
E
V
T
P
Q
N
I
T
L
N
P
G
F
G
G
Site 64
S788
K
K
R
N
L
V
V
S
V
D
D
G
G
T
F
Site 65
S806
L
H
R
V
W
K
G
S
S
V
H
Q
D
F
L
Site 66
Y816
H
Q
D
F
L
G
F
Y
V
L
D
S
H
R
M
Site 67
S820
L
G
F
Y
V
L
D
S
H
R
M
S
A
R
T
Site 68
S824
V
L
D
S
H
R
M
S
A
R
T
H
G
L
L
Site 69
T827
S
H
R
M
S
A
R
T
H
G
L
L
G
Q
F
Site 70
S843
H
P
I
G
F
E
V
S
D
I
H
P
G
S
D
Site 71
S849
V
S
D
I
H
P
G
S
D
P
T
K
P
D
A
Site 72
T857
D
P
T
K
P
D
A
T
M
V
V
R
N
R
R
Site 73
T866
V
V
R
N
R
R
L
T
V
T
R
G
L
Q
K
Site 74
T868
R
N
R
R
L
T
V
T
R
G
L
Q
K
D
Y
Site 75
Y875
T
R
G
L
Q
K
D
Y
S
K
D
P
W
H
G
Site 76
S876
R
G
L
Q
K
D
Y
S
K
D
P
W
H
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation