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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ITIH2
Full Name:
Inter-alpha-trypsin inhibitor heavy chain H2
Alias:
H2P; IGHEP2; Inter-alpha (globulin) inhibitor H2; Inter-alpha-inhibitor heavy chain 2; Inter-alpha-trypsin inhibitor complex component II; Inter-alpha-trypsin inhibitor heavy chain H2; ITI heavy chain H2; Serum-derived hyaluronan-associated protein; SHAP
Type:
Inhibitor protein
Mass (Da):
106463
Number AA:
946
UniProt ID:
P19823
International Prot ID:
IPI00305461
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0030212
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
E
I
P
I
N
G
L
S
E
F
V
D
Y
E
D
Site 2
Y52
L
V
A
E
N
R
R
Y
Q
R
S
L
P
G
E
Site 3
S55
E
N
R
R
Y
Q
R
S
L
P
G
E
S
E
E
Site 4
S60
Q
R
S
L
P
G
E
S
E
E
M
M
E
E
V
Site 5
Y73
E
V
D
Q
V
T
L
Y
S
Y
K
V
Q
S
T
Site 6
Y75
D
Q
V
T
L
Y
S
Y
K
V
Q
S
T
I
T
Site 7
S79
L
Y
S
Y
K
V
Q
S
T
I
T
S
R
M
A
Site 8
S98
Q
S
K
V
V
N
N
S
P
Q
P
Q
N
V
V
Site 9
T122
F
I
S
N
F
S
M
T
V
D
G
K
T
F
R
Site 10
T127
S
M
T
V
D
G
K
T
F
R
S
S
I
K
E
Site 11
S131
D
G
K
T
F
R
S
S
I
K
E
K
T
V
G
Site 12
T136
R
S
S
I
K
E
K
T
V
G
R
A
L
Y
A
Site 13
Y142
K
T
V
G
R
A
L
Y
A
Q
A
R
A
K
G
Site 14
T151
Q
A
R
A
K
G
K
T
A
G
L
V
R
S
S
Site 15
T167
L
D
M
E
N
F
R
T
E
V
N
V
L
P
G
Site 16
Y183
K
V
Q
F
E
L
H
Y
Q
E
V
K
W
R
K
Site 17
S193
V
K
W
R
K
L
G
S
Y
E
H
R
I
Y
L
Site 18
Y194
K
W
R
K
L
G
S
Y
E
H
R
I
Y
L
Q
Site 19
Y199
G
S
Y
E
H
R
I
Y
L
Q
P
G
R
L
A
Site 20
T229
R
F
L
H
V
P
D
T
F
E
G
H
F
D
G
Site 21
S250
G
Q
Q
K
A
H
V
S
F
K
P
T
V
A
Q
Site 22
T254
A
H
V
S
F
K
P
T
V
A
Q
Q
R
I
C
Site 23
Y277
D
G
E
L
V
V
L
Y
D
V
K
R
E
E
K
Site 24
T335
Q
T
V
E
A
M
K
T
I
L
D
D
L
R
A
Site 25
S347
L
R
A
E
D
H
F
S
V
I
D
F
N
Q
N
Site 26
S364
T
W
R
N
D
L
I
S
A
T
K
T
Q
V
A
Site 27
T368
D
L
I
S
A
T
K
T
Q
V
A
D
A
K
R
Site 28
T425
L
V
S
D
G
D
P
T
V
G
E
L
K
L
S
Site 29
S432
T
V
G
E
L
K
L
S
K
I
Q
K
N
V
K
Site 30
S447
E
N
I
Q
D
N
I
S
L
F
S
L
G
M
G
Site 31
Y459
G
M
G
F
D
V
D
Y
D
F
L
K
R
L
S
Site 32
S466
Y
D
F
L
K
R
L
S
N
E
N
H
G
I
A
Site 33
Y477
H
G
I
A
Q
R
I
Y
G
N
Q
D
T
S
S
Site 34
T482
R
I
Y
G
N
Q
D
T
S
S
Q
L
K
K
F
Site 35
S484
Y
G
N
Q
D
T
S
S
Q
L
K
K
F
Y
N
Site 36
Y490
S
S
Q
L
K
K
F
Y
N
Q
V
S
T
P
L
Site 37
T495
K
F
Y
N
Q
V
S
T
P
L
L
R
N
V
Q
Site 38
Y505
L
R
N
V
Q
F
N
Y
P
H
T
S
V
T
D
Site 39
Y521
T
Q
N
N
F
H
N
Y
F
G
G
S
E
I
V
Site 40
T546
D
Q
I
E
S
V
I
T
A
T
S
A
N
T
Q
Site 41
S570
D
D
L
Q
D
F
L
S
K
D
K
H
A
D
P
Site 42
S597
N
Q
L
L
A
E
R
S
L
A
P
T
A
A
A
Site 43
T601
A
E
R
S
L
A
P
T
A
A
A
K
R
R
I
Site 44
T609
A
A
A
K
R
R
I
T
R
S
I
L
Q
M
S
Site 45
S611
A
K
R
R
I
T
R
S
I
L
Q
M
S
L
D
Site 46
S649
D
A
P
P
Q
D
P
S
C
C
S
G
A
L
Y
Site 47
S659
S
G
A
L
Y
Y
G
S
K
V
V
P
D
S
T
Site 48
S665
G
S
K
V
V
P
D
S
T
P
S
W
A
N
P
Site 49
T666
S
K
V
V
P
D
S
T
P
S
W
A
N
P
S
Site 50
S668
V
V
P
D
S
T
P
S
W
A
N
P
S
P
T
Site 51
S673
T
P
S
W
A
N
P
S
P
T
P
V
I
S
M
Site 52
S679
P
S
P
T
P
V
I
S
M
L
A
Q
G
S
Q
Site 53
S690
Q
G
S
Q
V
L
E
S
T
P
P
P
H
V
M
Site 54
T691
G
S
Q
V
L
E
S
T
P
P
P
H
V
M
R
Site 55
Y708
N
D
P
H
F
I
I
Y
L
P
K
S
Q
K
N
Site 56
S736
N
L
V
S
D
P
E
S
G
I
V
V
N
G
Q
Site 57
S756
K
P
N
N
G
K
L
S
T
Y
F
G
K
L
G
Site 58
T757
P
N
N
G
K
L
S
T
Y
F
G
K
L
G
F
Site 59
Y758
N
N
G
K
L
S
T
Y
F
G
K
L
G
F
Y
Site 60
Y765
Y
F
G
K
L
G
F
Y
F
Q
S
E
D
I
K
Site 61
S768
K
L
G
F
Y
F
Q
S
E
D
I
K
I
E
I
Site 62
T781
E
I
S
T
E
T
I
T
L
S
H
G
S
S
T
Site 63
S783
S
T
E
T
I
T
L
S
H
G
S
S
T
F
S
Site 64
S786
T
I
T
L
S
H
G
S
S
T
F
S
L
S
W
Site 65
S787
I
T
L
S
H
G
S
S
T
F
S
L
S
W
S
Site 66
T788
T
L
S
H
G
S
S
T
F
S
L
S
W
S
D
Site 67
S790
S
H
G
S
S
T
F
S
L
S
W
S
D
T
A
Site 68
S792
G
S
S
T
F
S
L
S
W
S
D
T
A
Q
V
Site 69
S794
S
T
F
S
L
S
W
S
D
T
A
Q
V
T
N
Site 70
T796
F
S
L
S
W
S
D
T
A
Q
V
T
N
Q
R
Site 71
T817
K
E
K
V
V
T
I
T
L
D
K
E
M
S
F
Site 72
T849
L
G
I
Y
I
P
P
T
N
K
F
S
P
K
A
Site 73
S853
I
P
P
T
N
K
F
S
P
K
A
H
G
L
I
Site 74
Y904
T
R
G
L
Q
K
D
Y
R
T
D
L
V
F
G
Site 75
T906
G
L
Q
K
D
Y
R
T
D
L
V
F
G
T
D
Site 76
Y931
K
G
F
I
D
G
H
Y
K
D
Y
F
V
P
Q
Site 77
Y934
I
D
G
H
Y
K
D
Y
F
V
P
Q
L
Y
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation