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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HK1
Full Name:
Hexokinase-1
Alias:
Brain form hexokinase; Glycolytic enzyme; Hexokinase 1; Hexokinase type I; HK1-ta; HK1-tb; HKI; HXK1
Type:
Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.7.1.1; Kinase (non-protein); Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - fructose and mannose; Mitochondrial
Mass (Da):
102486
Number AA:
917
UniProt ID:
P19367
International Prot ID:
IPI00018246
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005741
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004396
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
A
A
Q
L
L
A
Y
Y
F
T
E
L
K
D
D
Site 2
Y25
Q
V
K
K
I
D
K
Y
L
Y
A
M
R
L
S
Site 3
Y27
K
K
I
D
K
Y
L
Y
A
M
R
L
S
D
E
Site 4
T35
A
M
R
L
S
D
E
T
L
I
D
I
M
T
R
Site 5
T41
E
T
L
I
D
I
M
T
R
F
R
K
E
M
K
Site 6
T58
L
S
R
D
F
N
P
T
A
T
V
K
M
L
P
Site 7
T60
R
D
F
N
P
T
A
T
V
K
M
L
P
T
F
Site 8
S70
M
L
P
T
F
V
R
S
I
P
D
G
S
E
K
Site 9
S88
I
A
L
D
L
G
G
S
S
F
R
I
L
R
V
Site 10
S89
A
L
D
L
G
G
S
S
F
R
I
L
R
V
Q
Site 11
Y112
V
H
M
E
S
E
V
Y
D
T
P
E
N
I
V
Site 12
T114
M
E
S
E
V
Y
D
T
P
E
N
I
V
H
G
Site 13
S124
N
I
V
H
G
S
G
S
Q
L
F
D
H
V
A
Site 14
T153
K
K
L
P
V
G
F
T
F
S
F
P
C
Q
Q
Site 15
S155
L
P
V
G
F
T
F
S
F
P
C
Q
Q
S
K
Site 16
Y199
A
I
K
K
R
G
D
Y
D
A
N
I
V
A
V
Site 17
Y238
G
T
G
T
N
A
C
Y
M
E
E
L
R
H
I
Site 18
S269
G
A
F
G
D
D
G
S
L
E
D
I
R
T
E
Site 19
T275
G
S
L
E
D
I
R
T
E
F
D
R
E
I
D
Site 20
S285
D
R
E
I
D
R
G
S
L
N
P
G
K
Q
L
Site 21
S298
Q
L
F
E
K
M
V
S
G
M
Y
L
G
E
L
Site 22
Y301
E
K
M
V
S
G
M
Y
L
G
E
L
V
R
L
Site 23
T336
L
T
R
G
K
F
N
T
S
D
V
S
A
I
E
Site 24
S337
T
R
G
K
F
N
T
S
D
V
S
A
I
E
K
Site 25
S364
T
R
L
G
V
E
P
S
D
D
D
C
V
S
V
Site 26
T403
R
L
R
D
N
K
G
T
P
R
L
R
T
T
V
Site 27
T408
K
G
T
P
R
L
R
T
T
V
G
V
D
G
S
Site 28
T409
G
T
P
R
L
R
T
T
V
G
V
D
G
S
L
Site 29
S415
T
T
V
G
V
D
G
S
L
Y
K
T
H
P
Q
Site 30
Y417
V
G
V
D
G
S
L
Y
K
T
H
P
Q
Y
S
Site 31
T419
V
D
G
S
L
Y
K
T
H
P
Q
Y
S
R
R
Site 32
Y423
L
Y
K
T
H
P
Q
Y
S
R
R
F
H
K
T
Site 33
T430
Y
S
R
R
F
H
K
T
L
R
R
L
V
P
D
Site 34
S445
S
D
V
R
F
L
L
S
E
S
G
S
G
K
G
Site 35
S447
V
R
F
L
L
S
E
S
G
S
G
K
G
A
A
Site 36
Y461
A
M
V
T
A
V
A
Y
R
L
A
E
Q
H
R
Site 37
T473
Q
H
R
Q
I
E
E
T
L
A
H
F
H
L
T
Site 38
T503
E
L
G
L
R
K
Q
T
H
N
N
A
V
V
K
Site 39
T519
L
P
S
F
V
R
R
T
P
D
G
T
E
N
G
Site 40
T523
V
R
R
T
P
D
G
T
E
N
G
D
F
L
A
Site 41
Y588
C
I
S
D
F
L
D
Y
M
G
I
K
G
P
R
Site 42
T601
P
R
M
P
L
G
F
T
F
S
F
P
C
Q
Q
Site 43
Y667
G
T
M
M
T
C
A
Y
E
E
P
T
C
E
V
Site 44
Y686
G
T
G
S
N
A
C
Y
M
E
E
M
K
N
V
Site 45
T723
G
C
L
D
D
I
R
T
H
Y
D
R
L
V
D
Site 46
Y725
L
D
D
I
R
T
H
Y
D
R
L
V
D
E
Y
Site 47
Y732
Y
D
R
L
V
D
E
Y
S
L
N
A
G
K
Q
Site 48
S733
D
R
L
V
D
E
Y
S
L
N
A
G
K
Q
R
Site 49
Y741
L
N
A
G
K
Q
R
Y
E
K
M
I
S
G
M
Site 50
Y749
E
K
M
I
S
G
M
Y
L
G
E
I
V
R
N
Site 51
T762
R
N
I
L
I
D
F
T
K
K
G
F
L
F
R
Site 52
T775
F
R
G
Q
I
S
E
T
L
K
T
R
G
I
F
Site 53
T778
Q
I
S
E
T
L
K
T
R
G
I
F
E
T
K
Site 54
T784
K
T
R
G
I
F
E
T
K
F
L
S
Q
I
E
Site 55
S788
I
F
E
T
K
F
L
S
Q
I
E
S
D
R
L
Site 56
S792
K
F
L
S
Q
I
E
S
D
R
L
A
L
L
Q
Site 57
S811
L
Q
Q
L
G
L
N
S
T
C
D
D
S
I
L
Site 58
T821
D
D
S
I
L
V
K
T
V
C
G
V
V
S
R
Site 59
S827
K
T
V
C
G
V
V
S
R
R
A
A
Q
L
C
Site 60
Y865
V
G
V
D
G
T
L
Y
K
L
H
P
H
F
S
Site 61
T878
F
S
R
I
M
H
Q
T
V
K
E
L
S
P
K
Site 62
S883
H
Q
T
V
K
E
L
S
P
K
C
N
V
S
F
Site 63
S889
L
S
P
K
C
N
V
S
F
L
L
S
E
D
G
Site 64
S893
C
N
V
S
F
L
L
S
E
D
G
S
G
K
G
Site 65
T913
A
V
G
V
R
L
R
T
E
A
S
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation