KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HDC
Full Name:
Histidine decarboxylase
Alias:
Type:
Mass (Da):
74141
Number AA:
662
UniProt ID:
P19113
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
M
E
P
E
E
Y
R
E
R
G
R
E
M
Site 2
Y17
R
G
R
E
M
V
D
Y
I
C
Q
Y
L
S
T
Site 3
Y21
M
V
D
Y
I
C
Q
Y
L
S
T
V
R
E
R
Site 4
S23
D
Y
I
C
Q
Y
L
S
T
V
R
E
R
R
V
Site 5
T24
Y
I
C
Q
Y
L
S
T
V
R
E
R
R
V
T
Site 6
T31
T
V
R
E
R
R
V
T
P
D
V
Q
P
G
Y
Site 7
Y38
T
P
D
V
Q
P
G
Y
L
R
A
Q
L
P
E
Site 8
S46
L
R
A
Q
L
P
E
S
A
P
E
D
P
D
S
Site 9
S53
S
A
P
E
D
P
D
S
W
D
S
I
F
G
D
Site 10
Y80
Q
S
P
H
M
H
A
Y
Y
P
A
L
T
S
W
Site 11
Y81
S
P
H
M
H
A
Y
Y
P
A
L
T
S
W
P
Site 12
S86
A
Y
Y
P
A
L
T
S
W
P
S
L
L
G
D
Site 13
S139
H
F
L
H
H
H
P
S
S
Q
G
G
G
V
L
Site 14
S140
F
L
H
H
H
P
S
S
Q
G
G
G
V
L
Q
Site 15
S148
Q
G
G
G
V
L
Q
S
T
V
S
E
S
T
L
Site 16
S172
K
I
L
E
M
K
T
S
E
P
D
A
D
E
S
Site 17
S179
S
E
P
D
A
D
E
S
C
L
N
A
R
L
V
Site 18
Y188
L
N
A
R
L
V
A
Y
A
S
D
Q
A
H
S
Site 19
S190
A
R
L
V
A
Y
A
S
D
Q
A
H
S
S
V
Site 20
S196
A
S
D
Q
A
H
S
S
V
E
K
A
G
L
I
Site 21
S218
L
P
V
D
D
N
F
S
L
R
G
E
A
L
Q
Site 22
Y295
G
F
L
K
G
I
E
Y
A
D
S
F
T
F
N
Site 23
S298
K
G
I
E
Y
A
D
S
F
T
F
N
P
S
K
Site 24
Y322
G
F
W
V
K
D
K
Y
K
L
Q
Q
T
F
S
Site 25
T327
D
K
Y
K
L
Q
Q
T
F
S
V
N
P
I
Y
Site 26
S329
Y
K
L
Q
Q
T
F
S
V
N
P
I
Y
L
R
Site 27
Y334
T
F
S
V
N
P
I
Y
L
R
H
A
N
S
G
Site 28
T382
Q
A
H
V
R
H
G
T
E
M
A
K
Y
F
E
Site 29
Y387
H
G
T
E
M
A
K
Y
F
E
S
L
V
R
N
Site 30
S390
E
M
A
K
Y
F
E
S
L
V
R
N
D
P
S
Site 31
S397
S
L
V
R
N
D
P
S
F
E
I
P
A
K
R
Site 32
T420
L
K
G
P
N
C
L
T
E
N
V
L
K
E
I
Site 33
S452
I
I
R
F
T
V
T
S
Q
F
T
T
R
D
D
Site 34
T456
T
V
T
S
Q
F
T
T
R
D
D
I
L
R
D
Site 35
S476
D
A
A
T
L
I
L
S
Q
H
C
T
S
Q
P
Site 36
T480
L
I
L
S
Q
H
C
T
S
Q
P
S
P
R
V
Site 37
S481
I
L
S
Q
H
C
T
S
Q
P
S
P
R
V
G
Site 38
S484
Q
H
C
T
S
Q
P
S
P
R
V
G
N
L
I
Site 39
S492
P
R
V
G
N
L
I
S
Q
I
R
G
A
R
A
Site 40
S508
A
C
G
T
S
L
Q
S
V
S
G
A
G
D
D
Site 41
S554
D
P
V
D
D
C
F
S
E
E
A
P
D
A
T
Site 42
S566
D
A
T
K
H
K
L
S
S
F
L
F
S
Y
L
Site 43
S567
A
T
K
H
K
L
S
S
F
L
F
S
Y
L
S
Site 44
S574
S
F
L
F
S
Y
L
S
V
Q
T
K
K
K
T
Site 45
T581
S
V
Q
T
K
K
K
T
V
R
S
L
S
C
N
Site 46
S584
T
K
K
K
T
V
R
S
L
S
C
N
S
V
P
Site 47
S586
K
K
T
V
R
S
L
S
C
N
S
V
P
V
S
Site 48
S589
V
R
S
L
S
C
N
S
V
P
V
S
A
Q
K
Site 49
S593
S
C
N
S
V
P
V
S
A
Q
K
P
L
P
T
Site 50
S603
K
P
L
P
T
E
A
S
V
K
N
G
G
S
S
Site 51
S609
A
S
V
K
N
G
G
S
S
R
V
R
I
F
S
Site 52
S610
S
V
K
N
G
G
S
S
R
V
R
I
F
S
R
Site 53
S616
S
S
R
V
R
I
F
S
R
F
P
E
D
M
M
Site 54
Y637
F
K
K
L
I
K
F
Y
S
V
P
S
F
P
E
Site 55
S638
K
K
L
I
K
F
Y
S
V
P
S
F
P
E
C
Site 56
S641
I
K
F
Y
S
V
P
S
F
P
E
C
S
S
Q
Site 57
S647
P
S
F
P
E
C
S
S
Q
C
G
L
Q
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation