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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TCP1
Full Name:
T-complex protein 1 subunit alpha
Alias:
CCT alpha; CCT1; CCTa; CCT-alpha; D6S230E; T-complex 1; TCP-1-alpha; TCPA; TCPA1
Type:
Chaperone protein
Mass (Da):
60344
Number AA:
556
UniProt ID:
P17987
International Prot ID:
IPI00290566
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005829
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
GO:0007021
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
T-complex protein 1 subunit alpha pan-specific antibody AB-NN346-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN346-1#T-complex protein 1 subunit alpha pan-specific antibody AB-NN346-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN346-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
G
P
L
S
V
F
G
D
R
S
T
Site 2
S12
L
S
V
F
G
D
R
S
T
G
E
T
I
R
S
Site 3
T13
S
V
F
G
D
R
S
T
G
E
T
I
R
S
Q
Site 4
T16
G
D
R
S
T
G
E
T
I
R
S
Q
N
V
M
Site 5
S19
S
T
G
E
T
I
R
S
Q
N
V
M
A
A
A
Site 6
S27
Q
N
V
M
A
A
A
S
I
A
N
I
V
K
S
Site 7
T53
V
D
D
I
G
D
V
T
I
T
N
D
G
A
T
Site 8
T90
D
K
E
V
G
D
G
T
T
S
V
V
I
I
A
Site 9
T91
K
E
V
G
D
G
T
T
S
V
V
I
I
A
A
Site 10
S92
E
V
G
D
G
T
T
S
V
V
I
I
A
A
E
Site 11
T115
V
K
Q
K
I
H
P
T
S
V
I
S
G
Y
R
Site 12
S116
K
Q
K
I
H
P
T
S
V
I
S
G
Y
R
L
Site 13
S119
I
H
P
T
S
V
I
S
G
Y
R
L
A
C
K
Site 14
Y121
P
T
S
V
I
S
G
Y
R
L
A
C
K
E
A
Site 15
S155
L
I
N
A
A
K
T
S
M
S
S
K
I
I
G
Site 16
S157
N
A
A
K
T
S
M
S
S
K
I
I
G
I
N
Site 17
S158
A
A
K
T
S
M
S
S
K
I
I
G
I
N
G
Site 18
Y181
D
A
V
L
A
I
K
Y
T
D
I
R
G
Q
P
Site 19
T182
A
V
L
A
I
K
Y
T
D
I
R
G
Q
P
R
Site 20
Y190
D
I
R
G
Q
P
R
Y
P
V
N
S
V
N
I
Site 21
S194
Q
P
R
Y
P
V
N
S
V
N
I
L
K
A
H
Site 22
S204
I
L
K
A
H
G
R
S
Q
M
E
S
M
L
I
Site 23
S208
H
G
R
S
Q
M
E
S
M
L
I
S
G
Y
A
Site 24
S240
K
I
A
C
L
D
F
S
L
Q
K
T
K
M
K
Site 25
T244
L
D
F
S
L
Q
K
T
K
M
K
L
G
V
Q
Site 26
S268
D
Q
I
R
Q
R
E
S
D
I
T
K
E
R
I
Site 27
T271
R
Q
R
E
S
D
I
T
K
E
R
I
Q
K
I
Site 28
Y299
I
D
D
M
C
L
K
Y
F
V
E
A
G
A
M
Site 29
T339
A
N
L
E
G
E
E
T
F
E
A
A
M
L
G
Site 30
S372
K
N
T
K
A
R
T
S
A
S
I
I
L
R
G
Site 31
S374
T
K
A
R
T
S
A
S
I
I
L
R
G
A
N
Site 32
S407
K
R
V
L
E
S
K
S
V
V
P
G
G
G
A
Site 33
Y426
L
S
I
Y
L
E
N
Y
A
T
S
M
G
S
R
Site 34
T428
I
Y
L
E
N
Y
A
T
S
M
G
S
R
E
Q
Site 35
T451
S
L
L
V
I
P
N
T
L
A
V
N
A
A
Q
Site 36
S491
K
W
I
G
L
D
L
S
N
G
K
P
R
D
N
Site 37
S513
P
T
I
V
K
V
K
S
L
K
F
A
T
E
A
Site 38
S537
L
I
K
L
H
P
E
S
K
D
D
K
H
G
S
Site 39
S544
S
K
D
D
K
H
G
S
Y
E
D
A
V
H
S
Site 40
Y545
K
D
D
K
H
G
S
Y
E
D
A
V
H
S
G
Site 41
S551
S
Y
E
D
A
V
H
S
G
A
L
N
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation