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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMC3
Full Name:
26S protease regulatory subunit 6A
Alias:
Proteasome (prosome, macropain) 26S subunit, ATPase, 3; Proteasome subunit P50; PRS6A; TAT-binding protein 1; TBP1; TBP-1
Type:
Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
49204
Number AA:
439
UniProt ID:
P17980
International Prot ID:
IPI00018398
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0000502
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0017111
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0044419
GO:0051436
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
N
L
L
P
N
I
E
S
P
V
T
R
Q
E
K
Site 2
T12
P
N
I
E
S
P
V
T
R
Q
E
K
M
A
T
Site 3
T19
T
R
Q
E
K
M
A
T
V
W
D
E
A
E
Q
Site 4
S37
G
E
E
V
L
K
M
S
T
E
E
I
I
Q
R
Site 5
S50
Q
R
T
R
L
L
D
S
E
I
K
I
M
K
S
Site 6
S57
S
E
I
K
I
M
K
S
E
V
L
R
V
T
H
Site 7
T63
K
S
E
V
L
R
V
T
H
E
L
Q
A
M
K
Site 8
T85
E
K
I
K
V
N
K
T
L
P
Y
L
V
S
N
Site 9
S115
G
A
N
I
D
L
D
S
Q
R
K
G
K
C
A
Site 10
T126
G
K
C
A
V
I
K
T
S
T
R
Q
T
Y
F
Site 11
Y132
K
T
S
T
R
Q
T
Y
F
L
P
V
I
G
L
Site 12
T166
L
I
L
E
T
L
P
T
E
Y
D
S
R
V
K
Site 13
Y168
L
E
T
L
P
T
E
Y
D
S
R
V
K
A
M
Site 14
T182
M
E
V
D
E
R
P
T
E
Q
Y
S
D
I
G
Site 15
Y185
D
E
R
P
T
E
Q
Y
S
D
I
G
G
L
D
Site 16
S186
E
R
P
T
E
Q
Y
S
D
I
G
G
L
D
K
Site 17
Y226
P
P
K
G
V
L
M
Y
G
P
P
G
T
G
K
Site 18
T293
D
E
L
D
A
I
G
T
K
R
F
D
S
E
K
Site 19
S298
I
G
T
K
R
F
D
S
E
K
A
G
D
R
E
Site 20
T309
G
D
R
E
V
Q
R
T
M
L
E
L
L
N
Q
Site 21
S345
L
D
P
A
L
L
R
S
G
R
L
D
R
K
I
Site 22
S376
H
S
R
K
M
N
V
S
P
D
V
N
Y
E
E
Site 23
Y381
N
V
S
P
D
V
N
Y
E
E
L
A
R
C
T
Site 24
T388
Y
E
E
L
A
R
C
T
D
D
F
N
G
A
Q
Site 25
T413
I
A
L
R
R
G
A
T
E
L
T
H
E
D
Y
Site 26
T416
R
R
G
A
T
E
L
T
H
E
D
Y
M
E
G
Site 27
Y420
T
E
L
T
H
E
D
Y
M
E
G
I
L
E
V
Site 28
Y438
K
K
A
N
L
Q
Y
Y
A
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation