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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPH1
Full Name:
Tryptophan 5-hydroxylase 1
Alias:
TPH; TPRH; TRPH; Tryptophan 5-monooxygenase; Tryptophan 5-monooxygenase 1; Tryptophan hydroxylase 1
Type:
Oxidoreductase; Amino Acid Metabolism - tryptophan; EC 1.14.16.4
Mass (Da):
50985
Number AA:
444
UniProt ID:
P17752
International Prot ID:
IPI00016810
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0016597
GO:0005506
GO:0004510
PhosphoSite+
KinaseNET
Biological Process:
GO:0009072
GO:0055114
GO:0042427
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
N
K
E
N
K
D
H
S
L
E
R
G
R
A
S
Site 2
S19
S
L
E
R
G
R
A
S
L
I
F
S
L
K
N
Site 3
S50
V
N
L
L
H
I
E
S
R
K
S
K
R
R
N
Site 4
S53
L
H
I
E
S
R
K
S
K
R
R
N
S
E
F
Site 5
S58
R
K
S
K
R
R
N
S
E
F
E
I
F
V
D
Site 6
S88
K
S
H
T
N
V
L
S
V
N
L
P
D
N
F
Site 7
T96
V
N
L
P
D
N
F
T
L
K
E
D
G
M
E
Site 8
T104
L
K
E
D
G
M
E
T
V
P
W
F
P
K
K
Site 9
Y141
P
G
F
K
D
N
V
Y
R
K
R
R
K
Y
F
Site 10
Y147
V
Y
R
K
R
R
K
Y
F
A
D
L
A
M
N
Site 11
T173
F
T
E
E
E
I
K
T
W
G
T
V
F
Q
E
Site 12
T176
E
E
I
K
T
W
G
T
V
F
Q
E
L
N
K
Site 13
Y185
F
Q
E
L
N
K
L
Y
P
T
H
A
C
R
E
Site 14
Y193
P
T
H
A
C
R
E
Y
L
K
N
L
P
L
L
Site 15
Y203
N
L
P
L
L
S
K
Y
C
G
Y
R
E
D
N
Site 16
T225
S
N
F
L
K
E
R
T
G
F
S
I
R
P
V
Site 17
S228
L
K
E
R
T
G
F
S
I
R
P
V
A
G
Y
Site 18
Y235
S
I
R
P
V
A
G
Y
L
S
P
R
D
F
L
Site 19
S237
R
P
V
A
G
Y
L
S
P
R
D
F
L
S
G
Site 20
Y255
R
V
F
H
C
T
Q
Y
V
R
H
S
S
D
P
Site 21
S260
T
Q
Y
V
R
H
S
S
D
P
F
Y
T
P
E
Site 22
Y264
R
H
S
S
D
P
F
Y
T
P
E
P
D
T
C
Site 23
T265
H
S
S
D
P
F
Y
T
P
E
P
D
T
C
H
Site 24
S290
E
P
S
F
A
Q
F
S
Q
E
I
G
L
A
S
Site 25
S297
S
Q
E
I
G
L
A
S
L
G
A
S
E
E
A
Site 26
S346
S
E
L
K
H
A
L
S
G
H
A
K
V
K
P
Site 27
S376
F
Q
D
V
Y
F
V
S
E
S
F
E
D
A
K
Site 28
S378
D
V
Y
F
V
S
E
S
F
E
D
A
K
E
K
Site 29
T390
K
E
K
M
R
E
F
T
K
T
I
K
R
P
F
Site 30
T392
K
M
R
E
F
T
K
T
I
K
R
P
F
G
V
Site 31
Y401
K
R
P
F
G
V
K
Y
N
P
Y
T
R
S
I
Site 32
Y404
F
G
V
K
Y
N
P
Y
T
R
S
I
Q
I
L
Site 33
T405
G
V
K
Y
N
P
Y
T
R
S
I
Q
I
L
K
Site 34
T414
S
I
Q
I
L
K
D
T
K
S
I
T
S
A
M
Site 35
S416
Q
I
L
K
D
T
K
S
I
T
S
A
M
N
E
Site 36
S432
Q
H
D
L
D
V
V
S
D
A
L
A
K
V
S
Site 37
S439
S
D
A
L
A
K
V
S
R
K
P
S
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation