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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP2A2
Full Name:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Alias:
AT2A2; ATA2; ATP2B; ATPA2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; DAR; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; SR Ca(2+)-ATPase 2
Type:
Endoplasmic reticulum; Membrane protein, integral; EC 3.6.3.8; Hydrolase; Adhesion; Transporter
Mass (Da):
114757
Number AA:
1042
UniProt ID:
P16615
International Prot ID:
IPI00177817
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005792
GO:0033017
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0048155
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0007155
GO:0008544
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
E
N
A
H
T
K
T
V
E
E
V
L
Site 2
T8
M
E
N
A
H
T
K
T
V
E
E
V
L
G
H
Site 3
S21
G
H
F
G
V
N
E
S
T
G
L
S
L
E
Q
Site 4
S25
V
N
E
S
T
G
L
S
L
E
Q
V
K
K
L
Site 5
S38
K
L
K
E
R
W
G
S
N
E
L
P
A
E
E
Site 6
T84
W
F
E
E
G
E
E
T
I
T
A
F
V
E
P
Site 7
T86
E
E
G
E
E
T
I
T
A
F
V
E
P
F
V
Site 8
Y122
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Site 9
S136
V
Y
R
Q
D
R
K
S
V
Q
R
I
K
A
K
Site 10
S167
P
A
D
I
R
L
T
S
I
K
S
T
T
L
R
Site 11
S170
I
R
L
T
S
I
K
S
T
T
L
R
V
D
Q
Site 12
T171
R
L
T
S
I
K
S
T
T
L
R
V
D
Q
S
Site 13
T172
L
T
S
I
K
S
T
T
L
R
V
D
Q
S
I
Site 14
S178
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
Site 15
S184
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
Site 16
S186
I
L
T
G
E
S
V
S
V
I
K
H
T
D
P
Site 17
S210
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
Site 18
T226
A
M
G
V
V
V
A
T
G
V
N
T
E
I
G
Site 19
T230
V
V
A
T
G
V
N
T
E
I
G
K
I
R
D
Site 20
T242
I
R
D
E
M
V
A
T
E
Q
E
R
T
P
L
Site 21
T247
V
A
T
E
Q
E
R
T
P
L
Q
Q
K
L
D
Site 22
S261
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
Site 23
S335
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
Site 24
T353
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
Site 25
T357
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
Site 26
T376
L
D
R
V
E
G
D
T
C
S
L
N
E
F
T
Site 27
S378
R
V
E
G
D
T
C
S
L
N
E
F
T
I
T
Site 28
Y407
K
P
V
N
C
H
Q
Y
D
G
L
V
E
L
A
Site 29
Y427
C
N
D
S
A
L
D
Y
N
E
A
K
G
V
Y
Site 30
Y434
Y
N
E
A
K
G
V
Y
E
K
V
G
E
A
T
Site 31
T441
Y
E
K
V
G
E
A
T
E
T
A
L
T
C
L
Site 32
T446
E
A
T
E
T
A
L
T
C
L
V
E
K
M
N
Site 33
T457
E
K
M
N
V
F
D
T
E
L
K
G
L
S
K
Site 34
S473
E
R
A
N
A
C
N
S
V
I
K
Q
L
M
K
Site 35
T484
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
Site 36
S488
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
Site 37
S493
E
F
S
R
D
R
K
S
M
S
V
Y
C
T
P
Site 38
S495
S
R
D
R
K
S
M
S
V
Y
C
T
P
N
K
Site 39
Y497
D
R
K
S
M
S
V
Y
C
T
P
N
K
P
S
Site 40
T499
K
S
M
S
V
Y
C
T
P
N
K
P
S
R
T
Site 41
S504
Y
C
T
P
N
K
P
S
R
T
S
M
S
K
M
Site 42
S507
P
N
K
P
S
R
T
S
M
S
K
M
F
V
K
Site 43
T525
E
G
V
I
D
R
C
T
H
I
R
V
G
S
T
Site 44
S531
C
T
H
I
R
V
G
S
T
K
V
P
M
T
S
Site 45
T537
G
S
T
K
V
P
M
T
S
G
V
K
Q
K
I
Site 46
S538
S
T
K
V
P
M
T
S
G
V
K
Q
K
I
M
Site 47
S546
G
V
K
Q
K
I
M
S
V
I
R
E
W
G
S
Site 48
S553
S
V
I
R
E
W
G
S
G
S
D
T
L
R
C
Site 49
S555
I
R
E
W
G
S
G
S
D
T
L
R
C
L
A
Site 50
T557
E
W
G
S
G
S
D
T
L
R
C
L
A
L
A
Site 51
S580
E
E
M
H
L
E
D
S
A
N
F
I
K
Y
E
Site 52
Y586
D
S
A
N
F
I
K
Y
E
T
N
L
T
F
V
Site 53
S608
P
P
R
I
E
V
A
S
S
V
K
L
C
R
Q
Site 54
S609
P
R
I
E
V
A
S
S
V
K
L
C
R
Q
A
Site 55
T624
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
Site 56
T648
F
G
Q
D
E
D
V
T
S
K
A
F
T
G
R
Site 57
S649
G
Q
D
E
D
V
T
S
K
A
F
T
G
R
E
Site 58
T653
D
V
T
S
K
A
F
T
G
R
E
F
D
E
L
Site 59
S663
E
F
D
E
L
N
P
S
A
Q
R
D
A
C
L
Site 60
S684
R
V
E
P
S
H
K
S
K
I
V
E
F
L
Q
Site 61
S721
E
I
G
I
A
M
G
S
G
T
A
V
A
K
T
Site 62
T723
G
I
A
M
G
S
G
T
A
V
A
K
T
A
S
Site 63
S730
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
Site 64
Y753
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
Site 65
Y762
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
Site 66
Y836
S
G
W
L
F
F
R
Y
L
A
I
G
C
Y
V
Site 67
S865
A
D
G
G
P
R
V
S
F
Y
Q
L
S
H
F
Site 68
Y867
G
G
P
R
V
S
F
Y
Q
L
S
H
F
L
Q
Site 69
S914
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
Site 70
S916
C
N
A
L
N
S
L
S
E
N
Q
S
L
L
R
Site 71
S920
N
S
L
S
E
N
Q
S
L
L
R
M
P
P
W
Site 72
S973
W
L
M
V
L
K
I
S
L
P
V
I
L
M
D
Site 73
Y990
L
K
F
V
A
R
N
Y
L
E
P
G
K
E
C
Site 74
T1002
K
E
C
V
Q
P
A
T
K
S
C
S
F
S
A
Site 75
S1006
Q
P
A
T
K
S
C
S
F
S
A
C
T
D
G
Site 76
S1008
A
T
K
S
C
S
F
S
A
C
T
D
G
I
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation