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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCSK2
Full Name:
Neuroendocrine convertase 2
Alias:
KEX2-like endoprotease 2;Prohormone convertase 2;Proprotein convertase 2
Type:
Mass (Da):
70565
Number AA:
638
UniProt ID:
P16519
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y67
L
P
F
A
E
G
L
Y
H
F
Y
H
N
G
L
Site 2
S82
A
K
A
K
R
R
R
S
L
H
H
K
Q
Q
L
Site 3
Y111
F
D
R
K
K
R
G
Y
R
D
I
N
E
I
D
Site 4
Y131
P
L
F
T
K
Q
W
Y
L
I
N
T
G
Q
A
Site 5
T141
N
T
G
Q
A
D
G
T
P
G
L
D
L
N
V
Site 6
T157
E
A
W
E
L
G
Y
T
G
K
G
V
T
I
G
Site 7
Y172
I
M
D
D
G
I
D
Y
L
H
P
D
L
A
S
Site 8
S179
Y
L
H
P
D
L
A
S
N
Y
N
A
E
A
S
Site 9
Y181
H
P
D
L
A
S
N
Y
N
A
E
A
S
Y
D
Site 10
S186
S
N
Y
N
A
E
A
S
Y
D
F
S
S
N
D
Site 11
S190
A
E
A
S
Y
D
F
S
S
N
D
P
Y
P
Y
Site 12
S191
E
A
S
Y
D
F
S
S
N
D
P
Y
P
Y
P
Site 13
Y195
D
F
S
S
N
D
P
Y
P
Y
P
R
Y
T
D
Site 14
Y197
S
S
N
D
P
Y
P
Y
P
R
Y
T
D
D
W
Site 15
Y200
D
P
Y
P
Y
P
R
Y
T
D
D
W
F
N
S
Site 16
Y265
M
P
Q
L
I
D
I
Y
S
A
S
W
G
P
T
Site 17
S266
P
Q
L
I
D
I
Y
S
A
S
W
G
P
T
D
Site 18
S268
L
I
D
I
Y
S
A
S
W
G
P
T
D
N
G
Site 19
T272
Y
S
A
S
W
G
P
T
D
N
G
K
T
V
D
Site 20
T277
G
P
T
D
N
G
K
T
V
D
G
P
R
E
L
Site 21
T285
V
D
G
P
R
E
L
T
L
Q
A
M
A
D
G
Site 22
S302
K
G
R
G
G
K
G
S
I
Y
V
W
A
S
G
Site 23
Y304
R
G
G
K
G
S
I
Y
V
W
A
S
G
D
G
Site 24
S308
G
S
I
Y
V
W
A
S
G
D
G
G
S
Y
D
Site 25
S330
A
S
S
M
W
T
I
S
I
N
S
A
I
N
D
Site 26
T340
S
A
I
N
D
G
R
T
A
L
Y
D
E
S
C
Site 27
Y343
N
D
G
R
T
A
L
Y
D
E
S
C
S
S
T
Site 28
S346
R
T
A
L
Y
D
E
S
C
S
S
T
L
A
S
Site 29
S348
A
L
Y
D
E
S
C
S
S
T
L
A
S
T
F
Site 30
S349
L
Y
D
E
S
C
S
S
T
L
A
S
T
F
S
Site 31
T350
Y
D
E
S
C
S
S
T
L
A
S
T
F
S
N
Site 32
S353
S
C
S
S
T
L
A
S
T
F
S
N
G
R
K
Site 33
T354
C
S
S
T
L
A
S
T
F
S
N
G
R
K
R
Site 34
S356
S
T
L
A
S
T
F
S
N
G
R
K
R
N
P
Site 35
Y373
G
V
A
T
T
D
L
Y
G
N
C
T
L
R
H
Site 36
T377
T
D
L
Y
G
N
C
T
L
R
H
S
G
T
S
Site 37
S381
G
N
C
T
L
R
H
S
G
T
S
A
A
A
P
Site 38
S384
T
L
R
H
S
G
T
S
A
A
A
P
E
A
A
Site 39
T405
L
E
A
N
L
G
L
T
W
R
D
M
Q
H
L
Site 40
T413
W
R
D
M
Q
H
L
T
V
L
T
S
K
R
N
Site 41
S417
Q
H
L
T
V
L
T
S
K
R
N
Q
L
H
D
Site 42
T461
K
M
A
K
D
W
K
T
V
P
E
R
F
H
C
Site 43
S472
R
F
H
C
V
G
G
S
V
Q
D
P
E
K
I
Site 44
Y503
G
K
E
N
F
V
R
Y
L
E
H
V
Q
A
V
Site 45
S527
D
L
N
I
N
M
T
S
P
M
G
T
K
S
I
Site 46
T531
N
M
T
S
P
M
G
T
K
S
I
L
L
S
R
Site 47
S533
T
S
P
M
G
T
K
S
I
L
L
S
R
R
P
Site 48
S537
G
T
K
S
I
L
L
S
R
R
P
R
D
D
D
Site 49
S545
R
R
P
R
D
D
D
S
K
V
G
F
D
K
W
Site 50
T567
W
G
E
D
A
R
G
T
W
T
L
E
L
G
F
Site 51
T588
K
G
V
L
K
E
W
T
L
M
L
H
G
T
Q
Site 52
T594
W
T
L
M
L
H
G
T
Q
S
A
P
Y
I
D
Site 53
Y599
H
G
T
Q
S
A
P
Y
I
D
Q
V
V
R
D
Site 54
Y607
I
D
Q
V
V
R
D
Y
Q
S
K
L
A
M
S
Site 55
S609
Q
V
V
R
D
Y
Q
S
K
L
A
M
S
K
K
Site 56
S630
L
D
E
A
V
E
R
S
L
K
S
I
L
N
K
Site 57
S633
A
V
E
R
S
L
K
S
I
L
N
K
N
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation