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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POR
Full Name:
NADPH--cytochrome P450 reductase
Alias:
CPR; CYPOR; Cytochrome P-450 reductase; FLJ26468; NCPR; P450 (cytochrome) oxidoreductase
Type:
EC 1.6.2.4; Oxidoreductase
Mass (Da):
76690
Number AA:
677
UniProt ID:
P16435
International Prot ID:
IPI00470467
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0010181
GO:0003958
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
NADPH--cytochrome P450 reductase pan-specific antibody AB-NN236-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN236-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
G
D
S
H
V
D
T
S
S
T
V
S
E
A
Site 2
S9
G
D
S
H
V
D
T
S
S
T
V
S
E
A
V
Site 3
S10
D
S
H
V
D
T
S
S
T
V
S
E
A
V
A
Site 4
T11
S
H
V
D
T
S
S
T
V
S
E
A
V
A
E
Site 5
S13
V
D
T
S
S
T
V
S
E
A
V
A
E
E
V
Site 6
T59
P
E
F
T
K
I
Q
T
L
T
S
S
V
R
E
Site 7
T61
F
T
K
I
Q
T
L
T
S
S
V
R
E
S
S
Site 8
S62
T
K
I
Q
T
L
T
S
S
V
R
E
S
S
F
Site 9
S63
K
I
Q
T
L
T
S
S
V
R
E
S
S
F
V
Site 10
S67
L
T
S
S
V
R
E
S
S
F
V
E
K
M
K
Site 11
S68
T
S
S
V
R
E
S
S
F
V
E
K
M
K
K
Site 12
S86
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
Site 13
T90
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
Site 14
S99
E
E
F
A
N
R
L
S
K
D
A
H
R
Y
G
Site 15
Y105
L
S
K
D
A
H
R
Y
G
M
R
G
M
S
A
Site 16
S111
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
Site 17
S123
E
Y
D
L
A
D
L
S
S
L
P
E
I
D
N
Site 18
S124
Y
D
L
A
D
L
S
S
L
P
E
I
D
N
A
Site 19
T146
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
Site 20
Y153
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
Site 21
T159
F
Y
D
W
L
Q
E
T
D
V
D
L
S
G
V
Site 22
Y178
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
Site 23
Y187
H
F
N
A
M
G
K
Y
V
D
K
R
L
E
Q
Site 24
T236
E
H
F
G
V
E
A
T
G
E
E
S
S
I
R
Site 25
S241
E
A
T
G
E
E
S
S
I
R
Q
Y
E
L
V
Site 26
Y245
E
E
S
S
I
R
Q
Y
E
L
V
V
H
T
D
Site 27
Y259
D
I
D
A
A
K
V
Y
M
G
E
M
G
R
L
Site 28
S268
G
E
M
G
R
L
K
S
Y
E
N
Q
K
P
P
Site 29
Y269
E
M
G
R
L
K
S
Y
E
N
Q
K
P
P
F
Site 30
T288
P
F
L
A
A
V
T
T
N
R
K
L
N
Q
G
Site 31
T296
N
R
K
L
N
Q
G
T
E
R
H
L
M
H
L
Site 32
S308
M
H
L
E
L
D
I
S
D
S
K
I
R
Y
E
Site 33
S310
L
E
L
D
I
S
D
S
K
I
R
Y
E
S
G
Site 34
Y314
I
S
D
S
K
I
R
Y
E
S
G
D
H
V
A
Site 35
S316
D
S
K
I
R
Y
E
S
G
D
H
V
A
V
Y
Site 36
Y323
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
Site 37
S347
A
D
L
D
V
V
M
S
L
N
N
L
D
E
E
Site 38
Y367
P
F
P
C
P
T
S
Y
R
T
A
L
T
Y
Y
Site 39
Y373
S
Y
R
T
A
L
T
Y
Y
L
D
I
T
N
P
Site 40
Y374
Y
R
T
A
L
T
Y
Y
L
D
I
T
N
P
P
Site 41
T378
L
T
Y
Y
L
D
I
T
N
P
P
R
T
N
V
Site 42
Y387
P
P
R
T
N
V
L
Y
E
L
A
Q
Y
A
S
Site 43
Y392
V
L
Y
E
L
A
Q
Y
A
S
E
P
S
E
Q
Site 44
S407
E
L
L
R
K
M
A
S
S
S
G
E
G
K
E
Site 45
S408
L
L
R
K
M
A
S
S
S
G
E
G
K
E
L
Site 46
S409
L
R
K
M
A
S
S
S
G
E
G
K
E
L
Y
Site 47
Y416
S
G
E
G
K
E
L
Y
L
S
W
V
V
E
A
Site 48
S418
E
G
K
E
L
Y
L
S
W
V
V
E
A
R
R
Site 49
S436
A
I
L
Q
D
C
P
S
L
R
P
P
I
D
H
Site 50
Y455
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
Site 51
Y456
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
Site 52
S457
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
Site 53
S460
A
R
Y
Y
S
I
A
S
S
S
K
V
H
P
N
Site 54
S461
R
Y
Y
S
I
A
S
S
S
K
V
H
P
N
S
Site 55
S462
Y
Y
S
I
A
S
S
S
K
V
H
P
N
S
V
Site 56
S516
V
P
M
F
V
R
K
S
Q
F
R
L
P
F
K
Site 57
T560
Q
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
Site 58
Y563
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
Site 59
Y564
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
Site 60
S569
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
Site 61
Y573
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Site 62
Y575
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
Site 63
T589
F
H
R
D
G
A
L
T
Q
L
N
V
A
F
S
Site 64
S596
T
Q
L
N
V
A
F
S
R
E
Q
S
H
K
V
Site 65
S600
V
A
F
S
R
E
Q
S
H
K
V
Y
V
Q
H
Site 66
Y604
R
E
Q
S
H
K
V
Y
V
Q
H
L
L
K
Q
Site 67
Y627
I
E
G
G
A
H
I
Y
V
C
G
D
A
R
N
Site 68
T642
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
Site 69
Y644
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
Site 70
Y661
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
Site 71
T667
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation