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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALOX15
Full Name:
Arachidonate 15-lipoxygenase
Alias:
15-LOX; 15-LOX-1; Arachidonate omega-6 lipoxygenase; EC 1.13.11.31; EC 1.13.11.33; LOG15; LOX15; LX12L
Type:
Oxidoreductase; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; EC 1.13.11.33; EC 1.13.11.31
Mass (Da):
74673
Number AA:
661
UniProt ID:
P16050
International Prot ID:
IPI00221221
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0050473
GO:0005506
GO:0016165
PhosphoSite+
KinaseNET
Biological Process:
GO:0006954
GO:0019370
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
I
R
V
S
T
G
A
S
L
Y
A
G
S
N
N
Site 2
Y97
D
E
V
R
F
P
C
Y
R
W
V
E
G
N
G
Site 3
S107
V
E
G
N
G
V
L
S
L
P
E
G
T
G
R
Site 4
Y139
L
E
E
R
R
K
L
Y
R
W
G
N
W
K
D
Site 5
Y158
N
M
A
G
A
K
L
Y
D
L
P
V
D
E
R
Site 6
S177
K
R
V
D
F
E
V
S
L
A
K
G
L
A
D
Site 7
S221
L
A
E
R
V
R
D
S
W
K
E
D
A
L
F
Site 8
Y230
K
E
D
A
L
F
G
Y
Q
F
L
N
G
A
N
Site 9
S244
N
P
V
V
L
R
R
S
A
H
L
P
A
R
L
Site 10
T323
I
Q
L
Q
L
P
R
T
G
S
P
P
P
P
L
Site 11
S325
L
Q
L
P
R
T
G
S
P
P
P
P
L
F
L
Site 12
S350
A
K
C
W
V
R
S
S
D
F
Q
L
H
E
L
Site 13
S359
F
Q
L
H
E
L
Q
S
H
L
L
R
G
H
L
Site 14
T405
E
I
N
V
R
A
R
T
G
L
V
S
D
M
G
Site 15
S409
R
A
R
T
G
L
V
S
D
M
G
I
F
D
Q
Site 16
T437
K
Q
A
G
A
F
L
T
Y
S
S
F
C
P
P
Site 17
Y438
Q
A
G
A
F
L
T
Y
S
S
F
C
P
P
D
Site 18
S439
A
G
A
F
L
T
Y
S
S
F
C
P
P
D
D
Site 19
S457
R
G
L
L
G
V
K
S
S
F
Y
A
Q
D
A
Site 20
S480
R
Y
V
E
G
I
V
S
L
H
Y
K
T
D
V
Site 21
Y483
E
G
I
V
S
L
H
Y
K
T
D
V
A
V
K
Site 22
T503
Q
T
W
C
R
E
I
T
E
I
G
L
Q
G
A
Site 23
S518
Q
D
R
G
F
P
V
S
L
Q
A
R
D
Q
V
Site 24
S542
T
C
T
G
Q
H
A
S
V
H
L
G
Q
L
D
Site 25
Y551
H
L
G
Q
L
D
W
Y
S
W
V
P
N
A
P
Site 26
T560
W
V
P
N
A
P
C
T
M
R
L
P
P
P
T
Site 27
T567
T
M
R
L
P
P
P
T
T
K
D
A
T
L
E
Site 28
T568
M
R
L
P
P
P
T
T
K
D
A
T
L
E
T
Site 29
T572
P
P
T
T
K
D
A
T
L
E
T
V
M
A
T
Site 30
T575
T
K
D
A
T
L
E
T
V
M
A
T
L
P
N
Site 31
S591
H
Q
A
S
L
Q
M
S
I
T
W
Q
L
G
R
Site 32
T593
A
S
L
Q
M
S
I
T
W
Q
L
G
R
R
Q
Site 33
Y613
V
G
Q
H
E
E
E
Y
F
S
G
P
E
P
K
Site 34
S615
Q
H
E
E
E
Y
F
S
G
P
E
P
K
A
V
Site 35
Y648
N
A
K
L
D
M
P
Y
E
Y
L
R
P
S
V
Site 36
Y650
K
L
D
M
P
Y
E
Y
L
R
P
S
V
V
E
Site 37
S654
P
Y
E
Y
L
R
P
S
V
V
E
N
S
V
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation