PhosphoNET

           
Protein Info 
   
Short Name:  ARSA
Full Name:  Arylsulfatase A
Alias:  ASA; Cerebroside-sulfatase; EC 3.1.6.8; Metachromatic leucodystrophy; MLD
Type:  EC 3.1.6.8; Lipid Metabolism - sphingolipid; Hydrolase
Mass (Da):  53588
Number AA:  507
UniProt ID:  P15289
International Prot ID:  IPI00744184
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005764     Uniprot OncoNet
Molecular Function:  GO:0004065  GO:0005509  GO:0004098 PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y39GYGDLGCYGHPSSTT
Site 2S44GCYGHPSSTTPNLDQ
Site 3T46YGHPSSTTPNLDQLA
Site 4Y63GLRFTDFYVPVSLCT
Site 5Y88LPVRMGMYPGVLVPS
Site 6S150RFLGIPYSHDQGPCQ
Site 7T160QGPCQNLTCFPPATP
Site 8Y222QDRPFFLYYASHHTH
Site 9Y223DRPFFLYYASHHTHY
Site 10Y230YASHHTHYPQFSGQS
Site 11S237YPQFSGQSFAERSGR
Site 12S242GQSFAERSGRGPFGD
Site 13S250GRGPFGDSLMELDAA
Site 14T286TADNGPETMRMSRGG
Site 15S290GPETMRMSRGGCSGL
Site 16T304LLRCGKGTTYEGGVR
Site 17Y306RCGKGTTYEGGVREP
Site 18S372TGKSPRQSLFFYPSY
Site 19Y376PRQSLFFYPSYPDEV
Site 20S378QSLFFYPSYPDEVRG
Site 21Y379SLFFYPSYPDEVRGV
Site 22Y394FAVRTGKYKAHFFTQ
Site 23T409GSAHSDTTADPACHA
Site 24S419PACHASSSLTAHEPP
Site 25T421CHASSSLTAHEPPLL
Site 26Y429AHEPPLLYDLSKDPG
Site 27S432PPLLYDLSKDPGENY
Site 28Y439SKDPGENYNLLGGVA
Site 29S475AAVTFGPSQVARGED
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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