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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DARS
Full Name:
Aspartyl-tRNA synthetase, cytoplasmic
Alias:
Aspartate tRNA ligase 1, cytoplasmic; Aspartate-tRNA ligase; Aspartate--tRNA ligase; Aspartyl-tRNA synthetase; AspRS; Cell proliferation-inducing protein 40; EC 6.1.1.12; SYDC
Type:
Enzyme, tRNA ligase
Mass (Da):
57136
Number AA:
501
UniProt ID:
P14868
International Prot ID:
IPI00216951
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004046
GO:0004815
PhosphoSite+
KinaseNET
Biological Process:
GO:0006422
GO:0006461
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
P
S
A
S
A
S
R
K
S
Q
E
Site 2
S7
_
M
P
S
A
S
A
S
R
K
S
Q
E
K
P
Site 3
S10
S
A
S
A
S
R
K
S
Q
E
K
P
R
E
I
Site 4
Y24
I
M
D
A
A
E
D
Y
A
K
E
R
Y
G
I
Site 5
Y29
E
D
Y
A
K
E
R
Y
G
I
S
S
M
I
Q
Site 6
S32
A
K
E
R
Y
G
I
S
S
M
I
Q
S
Q
E
Site 7
S33
K
E
R
Y
G
I
S
S
M
I
Q
S
Q
E
K
Site 8
S37
G
I
S
S
M
I
Q
S
Q
E
K
P
D
R
V
Site 9
T52
L
V
R
V
R
D
L
T
I
Q
K
A
D
E
V
Site 10
T68
W
V
R
A
R
V
H
T
S
R
A
K
G
K
Q
Site 11
S112
A
A
N
I
N
K
E
S
I
V
D
V
E
G
V
Site 12
S146
V
Q
K
I
Y
V
I
S
L
A
E
P
R
L
P
Site 13
T173
G
E
E
E
G
R
A
T
V
N
Q
D
T
R
L
Site 14
T189
N
R
V
I
D
L
R
T
S
T
S
Q
A
V
F
Site 15
S190
R
V
I
D
L
R
T
S
T
S
Q
A
V
F
R
Site 16
S192
I
D
L
R
T
S
T
S
Q
A
V
F
R
L
Q
Site 17
S225
I
Q
T
P
K
I
I
S
A
A
S
E
G
G
A
Site 18
T236
E
G
G
A
N
V
F
T
V
S
Y
F
K
N
N
Site 19
S238
G
A
N
V
F
T
V
S
Y
F
K
N
N
A
Y
Site 20
Y245
S
Y
F
K
N
N
A
Y
L
A
Q
S
P
Q
L
Site 21
S249
N
N
A
Y
L
A
Q
S
P
Q
L
Y
K
Q
M
Site 22
S277
P
V
F
R
A
E
D
S
N
T
H
R
H
L
T
Site 23
T279
F
R
A
E
D
S
N
T
H
R
H
L
T
E
F
Site 24
T284
S
N
T
H
R
H
L
T
E
F
V
G
L
D
I
Site 25
Y299
E
M
A
F
N
Y
H
Y
H
E
V
M
E
E
I
Site 26
T323
G
L
Q
E
R
F
Q
T
E
I
Q
T
V
N
K
Site 27
T343
P
F
K
F
L
E
P
T
L
R
L
E
Y
C
E
Site 28
S369
M
G
D
E
D
D
L
S
T
P
N
E
K
L
L
Site 29
T370
G
D
E
D
D
L
S
T
P
N
E
K
L
L
G
Site 30
Y384
G
H
L
V
K
E
K
Y
D
T
D
F
Y
I
L
Site 31
T386
L
V
K
E
K
Y
D
T
D
F
Y
I
L
D
K
Site 32
Y389
E
K
Y
D
T
D
F
Y
I
L
D
K
Y
P
L
Site 33
Y402
P
L
A
V
R
P
F
Y
T
M
P
D
P
R
N
Site 34
S415
R
N
P
K
Q
S
N
S
Y
D
M
F
M
R
G
Site 35
S427
M
R
G
E
E
I
L
S
G
A
Q
R
I
H
D
Site 36
T439
I
H
D
P
Q
L
L
T
E
R
A
L
H
H
G
Site 37
S458
K
I
K
A
Y
I
D
S
F
R
F
G
A
P
P
Site 38
T489
G
L
H
N
V
R
Q
T
S
M
F
P
R
D
P
Site 39
S490
L
H
N
V
R
Q
T
S
M
F
P
R
D
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation