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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IDE
Full Name:
Insulin-degrading enzyme
Alias:
Insulin protease; Insulysin
Type:
Mass (Da):
117951
Number AA:
1019
UniProt ID:
P14735
International Prot ID:
IPI00220373
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
GO:0005615
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004175
GO:0004222
PhosphoSite+
KinaseNET
Biological Process:
GO:0003006
GO:0006508
GO:0007154
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T38
L
C
G
F
Q
K
K
T
Y
S
K
M
N
N
P
Site 2
T55
K
R
I
G
N
H
I
T
K
S
P
E
D
K
R
Site 3
S57
I
G
N
H
I
T
K
S
P
E
D
K
R
E
Y
Site 4
Y64
S
P
E
D
K
R
E
Y
R
G
L
E
L
A
N
Site 5
S86
S
D
P
T
T
D
K
S
S
A
A
L
D
V
H
Site 6
S98
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
Site 7
Y121
L
F
L
G
T
K
K
Y
P
K
E
N
E
Y
S
Site 8
S128
Y
P
K
E
N
E
Y
S
Q
F
L
S
E
H
A
Site 9
S132
N
E
Y
S
Q
F
L
S
E
H
A
G
S
S
N
Site 10
S137
F
L
S
E
H
A
G
S
S
N
A
F
T
S
G
Site 11
T142
A
G
S
S
N
A
F
T
S
G
E
H
T
N
Y
Site 12
S143
G
S
S
N
A
F
T
S
G
E
H
T
N
Y
Y
Site 13
T147
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
Site 14
Y149
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
E
Site 15
Y150
S
G
E
H
T
N
Y
Y
F
D
V
S
H
E
H
Site 16
S188
R
E
V
N
A
V
D
S
E
H
E
K
N
V
M
Site 17
S216
G
N
P
K
H
P
F
S
K
F
G
T
G
N
K
Site 18
T220
H
P
F
S
K
F
G
T
G
N
K
Y
T
L
E
Site 19
Y224
K
F
G
T
G
N
K
Y
T
L
E
T
R
P
N
Site 20
S246
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
Site 21
T268
R
E
S
L
D
D
L
T
N
L
V
V
K
L
F
Site 22
Y302
E
E
H
L
K
Q
L
Y
K
I
V
P
I
K
D
Site 23
Y314
I
K
D
I
R
N
L
Y
V
T
F
P
I
P
D
Site 24
T316
D
I
R
N
L
Y
V
T
F
P
I
P
D
L
Q
Site 25
Y325
P
I
P
D
L
Q
K
Y
Y
K
S
N
P
G
H
Site 26
Y326
I
P
D
L
Q
K
Y
Y
K
S
N
P
G
H
Y
Site 27
S345
I
G
H
E
G
P
G
S
L
L
S
E
L
K
S
Site 28
S348
E
G
P
G
S
L
L
S
E
L
K
S
K
G
W
Site 29
S352
S
L
L
S
E
L
K
S
K
G
W
V
N
T
L
Site 30
Y433
D
K
E
R
P
R
G
Y
T
S
K
I
A
G
I
Site 31
T434
K
E
R
P
R
G
Y
T
S
K
I
A
G
I
L
Site 32
T451
Y
P
L
E
E
V
L
T
A
E
Y
L
L
E
E
Site 33
S482
N
V
R
V
A
I
V
S
K
S
F
E
G
K
T
Site 34
S484
R
V
A
I
V
S
K
S
F
E
G
K
T
D
R
Site 35
T489
S
K
S
F
E
G
K
T
D
R
T
E
E
W
Y
Site 36
T492
F
E
G
K
T
D
R
T
E
E
W
Y
G
T
Q
Site 37
Y496
T
D
R
T
E
E
W
Y
G
T
Q
Y
K
Q
E
Site 38
T498
R
T
E
E
W
Y
G
T
Q
Y
K
Q
E
A
I
Site 39
T533
T
K
N
E
F
I
P
T
N
F
E
I
L
P
L
Site 40
T545
L
P
L
E
K
E
A
T
P
Y
P
A
L
I
K
Site 41
Y547
L
E
K
E
A
T
P
Y
P
A
L
I
K
D
T
Site 42
Y596
H
C
N
M
A
Y
L
Y
L
E
L
L
K
D
S
Site 43
S603
Y
L
E
L
L
K
D
S
L
N
E
Y
A
Y
A
Site 44
Y607
L
K
D
S
L
N
E
Y
A
Y
A
A
E
L
A
Site 45
Y618
A
E
L
A
G
L
S
Y
D
L
Q
N
T
I
Y
Site 46
Y625
Y
D
L
Q
N
T
I
Y
G
M
Y
L
S
V
K
Site 47
Y628
Q
N
T
I
Y
G
M
Y
L
S
V
K
G
Y
N
Site 48
Y634
M
Y
L
S
V
K
G
Y
N
D
K
Q
P
I
L
Site 49
T651
K
I
I
E
K
M
A
T
F
E
I
D
E
K
R
Site 50
Y666
F
E
I
I
K
E
A
Y
M
R
S
L
N
N
F
Site 51
Y684
Q
P
H
Q
H
A
M
Y
Y
L
R
L
L
M
T
Site 52
Y685
P
H
Q
H
A
M
Y
Y
L
R
L
L
M
T
E
Site 53
T691
Y
Y
L
R
L
L
M
T
E
V
A
W
T
K
D
Site 54
T696
L
M
T
E
V
A
W
T
K
D
E
L
K
E
A
Site 55
T708
K
E
A
L
D
D
V
T
L
P
R
L
K
A
F
Site 56
T755
T
L
I
E
H
A
H
T
K
P
L
L
P
S
Q
Site 57
S761
H
T
K
P
L
L
P
S
Q
L
V
R
Y
R
E
Site 58
Y766
L
P
S
Q
L
V
R
Y
R
E
V
Q
L
P
D
Site 59
Y779
P
D
R
G
W
F
V
Y
Q
Q
R
N
E
V
H
Site 60
Y795
N
C
G
I
E
I
Y
Y
Q
T
D
M
Q
S
T
Site 61
T797
G
I
E
I
Y
Y
Q
T
D
M
Q
S
T
S
E
Site 62
S803
Q
T
D
M
Q
S
T
S
E
N
M
F
L
E
L
Site 63
T822
I
S
E
P
C
F
N
T
L
R
T
K
E
Q
L
Site 64
Y831
R
T
K
E
Q
L
G
Y
I
V
F
S
G
P
R
Site 65
S835
Q
L
G
Y
I
V
F
S
G
P
R
R
A
N
G
Site 66
S852
G
L
R
F
I
I
Q
S
E
K
P
P
H
Y
L
Site 67
Y858
Q
S
E
K
P
P
H
Y
L
E
S
R
V
E
A
Site 68
T869
R
V
E
A
F
L
I
T
M
E
K
S
I
E
D
Site 69
S873
F
L
I
T
M
E
K
S
I
E
D
M
T
E
E
Site 70
T878
E
K
S
I
E
D
M
T
E
E
A
F
Q
K
H
Site 71
Y907
L
S
A
E
C
A
K
Y
W
G
E
I
I
S
Q
Site 72
T923
Y
N
F
D
R
D
N
T
E
V
A
Y
L
K
T
Site 73
S955
A
P
R
R
H
K
V
S
V
H
V
L
A
R
E
Site 74
S981
C
Q
N
D
I
N
L
S
Q
A
P
A
L
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation