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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRF-2
Full Name:
Interferon regulatory factor 2
Alias:
IRF2
Type:
Transcription protein
Mass (Da):
39354
Number AA:
349
UniProt ID:
P14316
International Prot ID:
IPI00293657
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0000122
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T76
V
D
K
P
D
P
K
T
W
K
A
N
F
R
C
Site 2
S87
N
F
R
C
A
M
N
S
L
P
D
I
E
E
V
Site 3
S98
I
E
E
V
K
D
K
S
I
K
K
G
N
N
A
Site 4
Y109
G
N
N
A
F
R
V
Y
R
M
L
P
L
S
E
Site 5
S115
V
Y
R
M
L
P
L
S
E
R
P
S
K
K
G
Site 6
S119
L
P
L
S
E
R
P
S
K
K
G
K
K
P
K
Site 7
T127
K
K
G
K
K
P
K
T
E
K
E
D
K
V
K
Site 8
S143
I
K
Q
E
P
V
E
S
S
L
G
L
S
N
G
Site 9
S144
K
Q
E
P
V
E
S
S
L
G
L
S
N
G
V
Site 10
S148
V
E
S
S
L
G
L
S
N
G
V
S
D
L
S
Site 11
S152
L
G
L
S
N
G
V
S
D
L
S
P
E
Y
A
Site 12
S155
S
N
G
V
S
D
L
S
P
E
Y
A
V
L
T
Site 13
S185
V
G
Q
S
H
L
D
S
N
I
E
N
Q
E
I
Site 14
S209
V
V
E
V
T
T
E
S
D
E
Q
P
V
S
M
Site 15
S215
E
S
D
E
Q
P
V
S
M
S
E
L
Y
P
L
Site 16
S225
E
L
Y
P
L
Q
I
S
P
V
S
S
Y
A
E
Site 17
S228
P
L
Q
I
S
P
V
S
S
Y
A
E
S
E
T
Site 18
S229
L
Q
I
S
P
V
S
S
Y
A
E
S
E
T
T
Site 19
S233
P
V
S
S
Y
A
E
S
E
T
T
D
S
V
P
Site 20
T235
S
S
Y
A
E
S
E
T
T
D
S
V
P
S
D
Site 21
T236
S
Y
A
E
S
E
T
T
D
S
V
P
S
D
E
Site 22
S238
A
E
S
E
T
T
D
S
V
P
S
D
E
E
S
Site 23
S241
E
T
T
D
S
V
P
S
D
E
E
S
A
E
G
Site 24
S245
S
V
P
S
D
E
E
S
A
E
G
R
P
H
W
Site 25
Y262
R
N
I
E
G
K
Q
Y
L
S
N
M
G
T
R
Site 26
S264
I
E
G
K
Q
Y
L
S
N
M
G
T
R
G
S
Site 27
T268
Q
Y
L
S
N
M
G
T
R
G
S
Y
L
L
P
Site 28
S271
S
N
M
G
T
R
G
S
Y
L
L
P
G
M
A
Site 29
Y272
N
M
G
T
R
G
S
Y
L
L
P
G
M
A
S
Site 30
S283
G
M
A
S
F
V
T
S
N
K
P
D
L
Q
V
Site 31
Y301
E
E
S
N
P
V
P
Y
N
S
S
W
P
P
F
Site 32
S303
S
N
P
V
P
Y
N
S
S
W
P
P
F
Q
D
Site 33
S304
N
P
V
P
Y
N
S
S
W
P
P
F
Q
D
L
Site 34
S314
P
F
Q
D
L
P
L
S
S
S
M
T
P
A
S
Site 35
S316
Q
D
L
P
L
S
S
S
M
T
P
A
S
S
S
Site 36
T318
L
P
L
S
S
S
M
T
P
A
S
S
S
S
R
Site 37
S321
S
S
S
M
T
P
A
S
S
S
S
R
P
D
R
Site 38
S322
S
S
M
T
P
A
S
S
S
S
R
P
D
R
E
Site 39
S323
S
M
T
P
A
S
S
S
S
R
P
D
R
E
T
Site 40
T330
S
S
R
P
D
R
E
T
R
A
S
V
I
K
K
Site 41
S333
P
D
R
E
T
R
A
S
V
I
K
K
T
S
D
Site 42
T342
I
K
K
T
S
D
I
T
Q
A
R
V
K
S
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation