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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLS3
Full Name:
Plastin-3
Alias:
PLST; T isoform; T-plastin
Type:
Actin binding protein
Mass (Da):
70811
Number AA:
630
UniProt ID:
P13797
International Prot ID:
IPI00216694
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
D
E
M
A
T
T
Q
I
S
K
D
E
L
Site 2
S10
E
M
A
T
T
Q
I
S
K
D
E
L
D
E
L
Site 3
Y35
S
N
G
F
I
C
D
Y
E
L
H
E
L
F
K
Site 4
Y51
A
N
M
P
L
P
G
Y
K
V
R
E
I
I
Q
Site 5
S73
R
N
K
D
G
K
I
S
F
D
E
F
V
Y
I
Site 6
S86
Y
I
F
Q
E
V
K
S
S
D
I
A
K
T
F
Site 7
S87
I
F
Q
E
V
K
S
S
D
I
A
K
T
F
R
Site 8
T92
K
S
S
D
I
A
K
T
F
R
K
A
I
N
R
Site 9
S113
L
G
G
T
S
E
L
S
S
E
G
T
Q
H
S
Site 10
S114
G
G
T
S
E
L
S
S
E
G
T
Q
H
S
Y
Site 11
T117
S
E
L
S
S
E
G
T
Q
H
S
Y
S
E
E
Site 12
S120
S
S
E
G
T
Q
H
S
Y
S
E
E
E
K
Y
Site 13
Y121
S
E
G
T
Q
H
S
Y
S
E
E
E
K
Y
A
Site 14
S122
E
G
T
Q
H
S
Y
S
E
E
E
K
Y
A
F
Site 15
Y127
S
Y
S
E
E
E
K
Y
A
F
V
N
W
I
N
Site 16
T177
I
N
L
S
V
P
D
T
I
D
E
R
A
I
N
Site 17
T189
A
I
N
K
K
K
L
T
P
F
I
I
Q
E
N
Site 18
S246
L
F
A
D
I
E
L
S
R
N
E
A
L
A
A
Site 19
T260
A
L
L
R
D
G
E
T
L
E
E
L
M
K
L
Site 20
S268
L
E
E
L
M
K
L
S
P
E
E
L
L
L
R
Site 21
S293
W
Q
K
I
N
N
F
S
A
D
I
K
D
S
K
Site 22
Y302
D
I
K
D
S
K
A
Y
F
H
L
L
N
Q
I
Site 23
S326
P
R
I
D
I
N
M
S
G
F
N
E
T
D
D
Site 24
S339
D
D
L
K
R
A
E
S
M
L
Q
Q
A
D
K
Site 25
Y377
V
A
N
L
F
N
K
Y
P
A
L
T
K
P
E
Site 26
T391
E
N
Q
D
I
D
W
T
L
L
E
G
E
T
R
Site 27
T402
G
E
T
R
E
E
R
T
F
R
N
W
M
N
S
Site 28
Y420
N
P
H
V
N
H
L
Y
A
D
L
Q
D
A
L
Site 29
Y433
A
L
V
I
L
Q
L
Y
E
R
I
K
V
P
V
Site 30
Y450
S
K
V
N
K
P
P
Y
P
K
L
G
A
N
M
Site 31
Y465
K
K
L
E
N
C
N
Y
A
V
E
L
G
K
H
Site 32
S477
G
K
H
P
A
K
F
S
L
V
G
I
G
G
Q
Site 33
T492
D
L
N
D
G
N
Q
T
L
T
L
A
L
V
W
Site 34
Y505
V
W
Q
L
M
R
R
Y
T
L
N
V
L
E
D
Site 35
T506
W
Q
L
M
R
R
Y
T
L
N
V
L
E
D
L
Site 36
S533
N
W
V
N
R
T
L
S
E
A
G
K
S
T
S
Site 37
S538
T
L
S
E
A
G
K
S
T
S
I
Q
S
F
K
Site 38
S540
S
E
A
G
K
S
T
S
I
Q
S
F
K
D
K
Site 39
S543
G
K
S
T
S
I
Q
S
F
K
D
K
T
I
S
Site 40
T548
I
Q
S
F
K
D
K
T
I
S
S
S
L
A
V
Site 41
S550
S
F
K
D
K
T
I
S
S
S
L
A
V
V
D
Site 42
Y569
I
Q
P
G
C
I
N
Y
D
L
V
K
S
G
N
Site 43
S574
I
N
Y
D
L
V
K
S
G
N
L
T
E
D
D
Site 44
T578
L
V
K
S
G
N
L
T
E
D
D
K
H
N
N
Site 45
Y588
D
K
H
N
N
A
K
Y
A
V
S
M
A
R
R
Site 46
S591
N
N
A
K
Y
A
V
S
M
A
R
R
I
G
A
Site 47
Y601
R
R
I
G
A
R
V
Y
A
L
P
E
D
L
V
Site 48
T617
V
K
P
K
M
V
M
T
V
F
A
C
L
M
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation