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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
C6
Full Name:
Complement component C6
Alias:
Type:
Mass (Da):
104786
Number AA:
934
UniProt ID:
P13671
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T38
Q
W
T
S
C
S
K
T
C
N
S
G
T
Q
S
Site 2
S41
S
C
S
K
T
C
N
S
G
T
Q
S
R
H
R
Site 3
T43
S
K
T
C
N
S
G
T
Q
S
R
H
R
Q
I
Site 4
S45
T
C
N
S
G
T
Q
S
R
H
R
Q
I
V
V
Site 5
Y55
R
Q
I
V
V
D
K
Y
Y
Q
E
N
F
C
E
Site 6
Y56
Q
I
V
V
D
K
Y
Y
Q
E
N
F
C
E
Q
Site 7
S101
D
P
C
I
E
K
Q
S
K
V
R
S
V
L
R
Site 8
S105
E
K
Q
S
K
V
R
S
V
L
R
P
S
Q
F
Site 9
S110
V
R
S
V
L
R
P
S
Q
F
G
G
Q
P
C
Site 10
S148
K
N
K
F
R
C
D
S
G
R
C
I
A
R
K
Site 11
S168
E
N
D
C
G
D
N
S
D
E
R
D
C
G
R
Site 12
T176
D
E
R
D
C
G
R
T
K
A
V
C
T
R
K
Site 13
Y184
K
A
V
C
T
R
K
Y
N
P
I
P
S
V
Q
Site 14
S189
R
K
Y
N
P
I
P
S
V
Q
L
M
G
N
G
Site 15
S212
R
G
E
V
L
D
N
S
F
T
G
G
I
C
K
Site 16
T220
F
T
G
G
I
C
K
T
V
K
S
S
R
T
S
Site 17
S223
G
I
C
K
T
V
K
S
S
R
T
S
N
P
Y
Site 18
S227
T
V
K
S
S
R
T
S
N
P
Y
R
V
P
A
Site 19
Y230
S
S
R
T
S
N
P
Y
R
V
P
A
N
L
E
Site 20
T252
T
A
E
D
D
L
K
T
D
F
Y
K
D
L
T
Site 21
Y255
D
D
L
K
T
D
F
Y
K
D
L
T
S
L
G
Site 22
T259
T
D
F
Y
K
D
L
T
S
L
G
H
N
E
N
Site 23
S260
D
F
Y
K
D
L
T
S
L
G
H
N
E
N
Q
Site 24
S270
H
N
E
N
Q
Q
G
S
F
S
S
Q
G
G
S
Site 25
S272
E
N
Q
Q
G
S
F
S
S
Q
G
G
S
S
F
Site 26
S273
N
Q
Q
G
S
F
S
S
Q
G
G
S
S
F
S
Site 27
S280
S
Q
G
G
S
S
F
S
V
P
I
F
Y
S
S
Site 28
Y285
S
F
S
V
P
I
F
Y
S
S
K
R
S
E
N
Site 29
S286
F
S
V
P
I
F
Y
S
S
K
R
S
E
N
I
Site 30
S287
S
V
P
I
F
Y
S
S
K
R
S
E
N
I
N
Site 31
S290
I
F
Y
S
S
K
R
S
E
N
I
N
H
N
S
Site 32
S306
F
K
Q
A
I
Q
A
S
H
K
K
D
S
S
F
Site 33
S312
A
S
H
K
K
D
S
S
F
I
R
I
H
K
V
Site 34
Y349
L
N
H
L
P
L
E
Y
N
S
A
L
Y
S
R
Site 35
Y354
L
E
Y
N
S
A
L
Y
S
R
I
F
D
D
F
Site 36
S355
E
Y
N
S
A
L
Y
S
R
I
F
D
D
F
G
Site 37
T363
R
I
F
D
D
F
G
T
H
Y
F
T
S
G
S
Site 38
Y365
F
D
D
F
G
T
H
Y
F
T
S
G
S
L
G
Site 39
S370
T
H
Y
F
T
S
G
S
L
G
G
V
Y
D
L
Site 40
Y379
G
G
V
Y
D
L
L
Y
Q
F
S
S
E
E
L
Site 41
S382
Y
D
L
L
Y
Q
F
S
S
E
E
L
K
N
S
Site 42
S383
D
L
L
Y
Q
F
S
S
E
E
L
K
N
S
G
Site 43
S389
S
S
E
E
L
K
N
S
G
L
T
E
E
E
A
Site 44
T404
K
H
C
V
R
I
E
T
K
K
R
V
L
F
A
Site 45
T414
R
V
L
F
A
K
K
T
K
V
E
H
R
C
T
Site 46
T421
T
K
V
E
H
R
C
T
T
N
K
L
S
E
K
Site 47
T422
K
V
E
H
R
C
T
T
N
K
L
S
E
K
H
Site 48
S426
R
C
T
T
N
K
L
S
E
K
H
E
G
S
F
Site 49
S432
L
S
E
K
H
E
G
S
F
I
Q
G
A
E
K
Site 50
S442
Q
G
A
E
K
S
I
S
L
I
R
G
G
R
S
Site 51
Y451
I
R
G
G
R
S
E
Y
G
A
A
L
A
W
E
Site 52
S462
L
A
W
E
K
G
S
S
G
L
E
E
K
T
F
Site 53
T468
S
S
G
L
E
E
K
T
F
S
E
W
L
E
S
Site 54
S470
G
L
E
E
K
T
F
S
E
W
L
E
S
V
K
Site 55
S475
T
F
S
E
W
L
E
S
V
K
E
N
P
A
V
Site 56
T502
R
N
I
P
C
A
V
T
K
R
N
N
L
R
K
Site 57
Y514
L
R
K
A
L
Q
E
Y
A
A
K
F
D
P
C
Site 58
T533
C
P
N
N
G
R
P
T
L
S
G
T
E
C
L
Site 59
S535
N
N
G
R
P
T
L
S
G
T
E
C
L
C
V
Site 60
S556
G
E
N
C
E
K
Q
S
P
D
Y
K
S
N
A
Site 61
Y559
C
E
K
Q
S
P
D
Y
K
S
N
A
V
D
G
Site 62
S561
K
Q
S
P
D
Y
K
S
N
A
V
D
G
Q
W
Site 63
T580
S
W
S
T
C
D
A
T
Y
K
R
S
R
T
R
Site 64
Y581
W
S
T
C
D
A
T
Y
K
R
S
R
T
R
E
Site 65
T586
A
T
Y
K
R
S
R
T
R
E
C
N
N
P
A
Site 66
S642
L
P
E
I
E
A
D
S
G
C
P
Q
P
V
P
Site 67
Y662
I
R
N
E
K
Q
L
Y
L
V
G
E
D
V
E
Site 68
T678
S
C
L
T
G
F
E
T
V
G
Y
Q
Y
F
R
Site 69
Y681
T
G
F
E
T
V
G
Y
Q
Y
F
R
C
L
P
Site 70
Y683
F
E
T
V
G
Y
Q
Y
F
R
C
L
P
D
G
Site 71
T702
G
D
V
E
C
Q
R
T
E
C
I
K
P
V
V
Site 72
T716
V
Q
E
V
L
T
I
T
P
F
Q
R
L
Y
R
Site 73
Y722
I
T
P
F
Q
R
L
Y
R
I
G
E
S
I
E
Site 74
S742
G
F
V
V
A
G
P
S
R
Y
T
C
Q
G
N
Site 75
Y744
V
V
A
G
P
S
R
Y
T
C
Q
G
N
S
W
Site 76
T745
V
A
G
P
S
R
Y
T
C
Q
G
N
S
W
T
Site 77
T752
T
C
Q
G
N
S
W
T
P
P
I
S
N
S
L
Site 78
S756
N
S
W
T
P
P
I
S
N
S
L
T
C
E
K
Site 79
T760
P
P
I
S
N
S
L
T
C
E
K
D
T
L
T
Site 80
T765
S
L
T
C
E
K
D
T
L
T
K
L
K
G
H
Site 81
T767
T
C
E
K
D
T
L
T
K
L
K
G
H
C
Q
Site 82
S782
L
G
Q
K
Q
S
G
S
E
C
I
C
M
S
P
Site 83
S788
G
S
E
C
I
C
M
S
P
E
E
D
C
S
H
Site 84
S794
M
S
P
E
E
D
C
S
H
H
S
E
D
L
C
Site 85
T805
E
D
L
C
V
F
D
T
D
S
N
D
Y
F
T
Site 86
Y810
F
D
T
D
S
N
D
Y
F
T
S
P
A
C
K
Site 87
S813
D
S
N
D
Y
F
T
S
P
A
C
K
F
L
A
Site 88
S853
G
L
E
R
T
R
L
S
S
N
S
T
K
K
E
Site 89
S854
L
E
R
T
R
L
S
S
N
S
T
K
K
E
S
Site 90
S856
R
T
R
L
S
S
N
S
T
K
K
E
S
C
G
Site 91
T857
T
R
L
S
S
N
S
T
K
K
E
S
C
G
Y
Site 92
Y864
T
K
K
E
S
C
G
Y
D
T
C
Y
D
W
E
Site 93
Y896
F
K
G
G
N
Q
L
Y
C
V
K
M
G
S
S
Site 94
S905
V
K
M
G
S
S
T
S
E
K
T
L
N
I
C
Site 95
T908
G
S
S
T
S
E
K
T
L
N
I
C
E
V
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation