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Updated November 2019
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Protein Info
Short Name:
VCAN
Full Name:
Versican core protein
Alias:
Chondroitin sulfate proteoglycan core 2; GHAP; Glial hyaluronate-binding; Large fibroblast proteoglycan; PG-M; Versica; VERSICAN; Versican proteoglycan
Type:
Adhesion
Mass (Da):
372820
Number AA:
3396
UniProt ID:
P13611
International Prot ID:
IPI00009802
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005540
GO:0005529
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0008037
GO:0008347
Phosida
TranscriptoNet
STRING
Kinexus Products
Versican core protein pan-specific antibody AB-NN360-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN360-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
H
K
V
K
V
G
K
S
P
P
V
R
G
S
L
Site 2
S35
K
S
P
P
V
R
G
S
L
S
G
K
V
S
L
Site 3
S37
P
P
V
R
G
S
L
S
G
K
V
S
L
P
C
Site 4
S41
G
S
L
S
G
K
V
S
L
P
C
H
F
S
T
Site 5
T48
S
L
P
C
H
F
S
T
M
P
T
L
P
P
S
Site 6
T51
C
H
F
S
T
M
P
T
L
P
P
S
Y
N
T
Site 7
S55
T
M
P
T
L
P
P
S
Y
N
T
S
E
F
L
Site 8
S59
L
P
P
S
Y
N
T
S
E
F
L
R
I
K
W
Site 9
S67
E
F
L
R
I
K
W
S
K
I
E
V
D
K
N
Site 10
Y97
N
I
K
I
G
Q
D
Y
K
G
R
V
S
V
P
Site 11
S102
Q
D
Y
K
G
R
V
S
V
P
T
H
P
E
A
Site 12
T105
K
G
R
V
S
V
P
T
H
P
E
A
V
G
D
Site 13
Y134
L
Y
R
C
D
V
M
Y
G
I
E
D
T
Q
D
Site 14
T139
V
M
Y
G
I
E
D
T
Q
D
T
V
S
L
T
Site 15
T142
G
I
E
D
T
Q
D
T
V
S
L
T
V
D
G
Site 16
S144
E
D
T
Q
D
T
V
S
L
T
V
D
G
V
V
Site 17
Y154
V
D
G
V
V
F
H
Y
R
A
A
T
S
R
Y
Site 18
T158
V
F
H
Y
R
A
A
T
S
R
Y
T
L
N
F
Site 19
T162
R
A
A
T
S
R
Y
T
L
N
F
E
A
A
Q
Site 20
Y189
P
E
Q
L
F
A
A
Y
E
D
G
F
E
Q
C
Site 21
T205
A
G
W
L
A
D
Q
T
V
R
Y
P
I
R
A
Site 22
Y208
L
A
D
Q
T
V
R
Y
P
I
R
A
P
R
V
Site 23
Y218
R
A
P
R
V
G
C
Y
G
D
K
M
G
K
A
Site 24
Y230
G
K
A
G
V
R
T
Y
G
F
R
S
P
Q
E
Site 25
S234
V
R
T
Y
G
F
R
S
P
Q
E
T
Y
D
V
Site 26
Y242
P
Q
E
T
Y
D
V
Y
C
Y
V
D
H
L
D
Site 27
Y244
E
T
Y
D
V
Y
C
Y
V
D
H
L
D
G
D
Site 28
T279
N
Q
D
A
R
L
A
T
V
G
E
L
Q
A
A
Site 29
Y296
N
G
F
D
Q
C
D
Y
G
W
L
S
D
A
S
Site 30
S303
Y
G
W
L
S
D
A
S
V
R
H
P
V
T
V
Site 31
T309
A
S
V
R
H
P
V
T
V
A
R
A
Q
C
G
Site 32
T324
G
G
L
L
G
V
R
T
L
Y
R
F
E
N
Q
Site 33
Y326
L
L
G
V
R
T
L
Y
R
F
E
N
Q
T
G
Site 34
T332
L
Y
R
F
E
N
Q
T
G
F
P
P
P
D
S
Site 35
S339
T
G
F
P
P
P
D
S
R
F
D
A
Y
C
F
Site 36
Y344
P
D
S
R
F
D
A
Y
C
F
K
P
K
E
A
Site 37
T362
D
L
S
I
L
A
E
T
A
S
P
S
L
S
K
Site 38
S364
S
I
L
A
E
T
A
S
P
S
L
S
K
E
P
Site 39
S366
L
A
E
T
A
S
P
S
L
S
K
E
P
Q
M
Site 40
S368
E
T
A
S
P
S
L
S
K
E
P
Q
M
V
S
Site 41
S375
S
K
E
P
Q
M
V
S
D
R
T
T
P
I
I
Site 42
T393
D
E
L
P
V
I
P
T
E
F
P
P
V
G
N
Site 43
T409
V
S
F
E
Q
K
A
T
V
Q
P
Q
A
I
T
Site 44
S418
Q
P
Q
A
I
T
D
S
L
A
T
K
L
P
T
Site 45
T425
S
L
A
T
K
L
P
T
P
T
G
S
T
K
K
Site 46
Y439
K
P
W
D
M
D
D
Y
S
P
S
A
S
G
P
Site 47
S440
P
W
D
M
D
D
Y
S
P
S
A
S
G
P
L
Site 48
S442
D
M
D
D
Y
S
P
S
A
S
G
P
L
G
K
Site 49
S444
D
D
Y
S
P
S
A
S
G
P
L
G
K
L
D
Site 50
S453
P
L
G
K
L
D
I
S
E
I
K
E
E
V
L
Site 51
S462
I
K
E
E
V
L
Q
S
T
T
G
V
S
H
Y
Site 52
Y469
S
T
T
G
V
S
H
Y
A
T
D
S
W
D
G
Site 53
T471
T
G
V
S
H
Y
A
T
D
S
W
D
G
V
V
Site 54
S473
V
S
H
Y
A
T
D
S
W
D
G
V
V
E
D
Site 55
T483
G
V
V
E
D
K
Q
T
Q
E
S
V
T
Q
I
Site 56
S486
E
D
K
Q
T
Q
E
S
V
T
Q
I
E
Q
I
Site 57
S510
E
I
L
K
H
I
P
S
K
E
F
P
V
T
E
Site 58
T516
P
S
K
E
F
P
V
T
E
T
P
L
V
T
A
Site 59
T518
K
E
F
P
V
T
E
T
P
L
V
T
A
R
M
Site 60
S529
T
A
R
M
I
L
E
S
K
T
E
K
K
M
V
Site 61
T531
R
M
I
L
E
S
K
T
E
K
K
M
V
S
T
Site 62
S537
K
T
E
K
K
M
V
S
T
V
S
E
L
V
T
Site 63
T544
S
T
V
S
E
L
V
T
T
G
H
Y
G
F
T
Site 64
T561
E
E
D
D
E
D
R
T
L
T
V
G
S
D
E
Site 65
T563
D
D
E
D
R
T
L
T
V
G
S
D
E
S
T
Site 66
S566
D
R
T
L
T
V
G
S
D
E
S
T
L
I
F
Site 67
T570
T
V
G
S
D
E
S
T
L
I
F
D
Q
I
P
Site 68
T581
D
Q
I
P
E
V
I
T
V
S
K
T
S
E
D
Site 69
T585
E
V
I
T
V
S
K
T
S
E
D
T
I
H
T
Site 70
S599
T
H
L
E
D
L
E
S
V
S
A
S
T
T
V
Site 71
S601
L
E
D
L
E
S
V
S
A
S
T
T
V
S
P
Site 72
S618
M
P
D
N
N
G
S
S
M
D
D
W
E
E
R
Site 73
T627
D
D
W
E
E
R
Q
T
S
G
R
I
T
E
E
Site 74
S628
D
W
E
E
R
Q
T
S
G
R
I
T
E
E
F
Site 75
T632
R
Q
T
S
G
R
I
T
E
E
F
L
G
K
Y
Site 76
Y639
T
E
E
F
L
G
K
Y
L
S
T
T
P
F
P
Site 77
S641
E
F
L
G
K
Y
L
S
T
T
P
F
P
S
Q
Site 78
T642
F
L
G
K
Y
L
S
T
T
P
F
P
S
Q
H
Site 79
T643
L
G
K
Y
L
S
T
T
P
F
P
S
Q
H
R
Site 80
S647
L
S
T
T
P
F
P
S
Q
H
R
T
E
I
E
Site 81
T651
P
F
P
S
Q
H
R
T
E
I
E
L
F
P
Y
Site 82
Y673
E
G
I
S
T
V
I
Y
P
S
L
Q
T
E
M
Site 83
S675
I
S
T
V
I
Y
P
S
L
Q
T
E
M
T
H
Site 84
T681
P
S
L
Q
T
E
M
T
H
R
R
E
R
T
E
Site 85
T687
M
T
H
R
R
E
R
T
E
T
L
I
P
E
M
Site 86
T689
H
R
R
E
R
T
E
T
L
I
P
E
M
R
T
Site 87
T698
I
P
E
M
R
T
D
T
Y
T
D
E
I
Q
E
Site 88
Y699
P
E
M
R
T
D
T
Y
T
D
E
I
Q
E
E
Site 89
T700
E
M
R
T
D
T
Y
T
D
E
I
Q
E
E
I
Site 90
T708
D
E
I
Q
E
E
I
T
K
S
P
F
M
G
K
Site 91
S710
I
Q
E
E
I
T
K
S
P
F
M
G
K
T
E
Site 92
T716
K
S
P
F
M
G
K
T
E
E
E
V
F
S
G
Site 93
S722
K
T
E
E
E
V
F
S
G
M
K
L
S
T
S
Site 94
S727
V
F
S
G
M
K
L
S
T
S
L
S
E
P
I
Site 95
S729
S
G
M
K
L
S
T
S
L
S
E
P
I
H
V
Site 96
S731
M
K
L
S
T
S
L
S
E
P
I
H
V
T
E
Site 97
S740
P
I
H
V
T
E
S
S
V
E
M
T
K
S
F
Site 98
T744
T
E
S
S
V
E
M
T
K
S
F
D
F
P
T
Site 99
S757
P
T
L
I
T
K
L
S
A
E
P
T
E
V
R
Site 100
T761
T
K
L
S
A
E
P
T
E
V
R
D
M
E
E
Site 101
T771
R
D
M
E
E
D
F
T
A
T
P
G
T
T
K
Site 102
T773
M
E
E
D
F
T
A
T
P
G
T
T
K
Y
D
Site 103
Y779
A
T
P
G
T
T
K
Y
D
E
N
I
T
T
V
Site 104
T785
K
Y
D
E
N
I
T
T
V
L
L
A
H
G
T
Site 105
T799
T
L
S
V
E
A
A
T
V
S
K
W
S
W
D
Site 106
S801
S
V
E
A
A
T
V
S
K
W
S
W
D
E
D
Site 107
T810
W
S
W
D
E
D
N
T
T
S
K
P
L
E
S
Site 108
T811
S
W
D
E
D
N
T
T
S
K
P
L
E
S
T
Site 109
S817
T
T
S
K
P
L
E
S
T
E
P
S
A
S
S
Site 110
T818
T
S
K
P
L
E
S
T
E
P
S
A
S
S
K
Site 111
S821
P
L
E
S
T
E
P
S
A
S
S
K
L
P
P
Site 112
S823
E
S
T
E
P
S
A
S
S
K
L
P
P
A
L
Site 113
S824
S
T
E
P
S
A
S
S
K
L
P
P
A
L
L
Site 114
S845
G
K
D
K
D
I
P
S
F
T
E
D
G
A
D
Site 115
T855
E
D
G
A
D
E
F
T
L
I
P
D
S
T
Q
Site 116
S860
E
F
T
L
I
P
D
S
T
Q
K
Q
L
E
E
Site 117
T861
F
T
L
I
P
D
S
T
Q
K
Q
L
E
E
V
Site 118
T880
I
A
A
H
G
K
F
T
I
R
F
Q
P
T
T
Site 119
T887
T
I
R
F
Q
P
T
T
S
T
G
I
A
E
K
Site 120
S895
S
T
G
I
A
E
K
S
T
L
R
D
S
T
T
Site 121
T896
T
G
I
A
E
K
S
T
L
R
D
S
T
T
E
Site 122
S900
E
K
S
T
L
R
D
S
T
T
E
E
K
V
P
Site 123
T901
K
S
T
L
R
D
S
T
T
E
E
K
V
P
P
Site 124
T902
S
T
L
R
D
S
T
T
E
E
K
V
P
P
I
Site 125
Y917
T
S
T
E
G
Q
V
Y
A
T
M
E
G
S
A
Site 126
S934
E
V
E
D
V
D
L
S
K
P
V
S
T
V
P
Site 127
S938
V
D
L
S
K
P
V
S
T
V
P
Q
F
A
H
Site 128
S956
V
E
G
L
A
F
V
S
Y
S
S
T
Q
E
P
Site 129
Y957
E
G
L
A
F
V
S
Y
S
S
T
Q
E
P
T
Site 130
T960
A
F
V
S
Y
S
S
T
Q
E
P
T
T
Y
V
Site 131
T965
S
S
T
Q
E
P
T
T
Y
V
D
S
S
H
T
Site 132
Y966
S
T
Q
E
P
T
T
Y
V
D
S
S
H
T
I
Site 133
S969
E
P
T
T
Y
V
D
S
S
H
T
I
P
L
S
Site 134
S970
P
T
T
Y
V
D
S
S
H
T
I
P
L
S
V
Site 135
S976
S
S
H
T
I
P
L
S
V
I
P
K
T
D
W
Site 136
S989
D
W
G
V
L
V
P
S
V
P
S
E
D
E
V
Site 137
S1001
D
E
V
L
G
E
P
S
Q
D
I
L
V
I
D
Site 138
T1015
D
Q
T
R
L
E
A
T
I
S
P
E
T
M
R
Site 139
S1017
T
R
L
E
A
T
I
S
P
E
T
M
R
T
T
Site 140
T1020
E
A
T
I
S
P
E
T
M
R
T
T
K
I
T
Site 141
T1023
I
S
P
E
T
M
R
T
T
K
I
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H
V
N
I
E
A
T
F
K
P
S
S
E
E
Site 446
S2879
I
E
A
T
F
K
P
S
S
E
E
Y
L
H
I
Site 447
S2880
E
A
T
F
K
P
S
S
E
E
Y
L
H
I
T
Site 448
Y2883
F
K
P
S
S
E
E
Y
L
H
I
T
E
P
P
Site 449
T2887
S
E
E
Y
L
H
I
T
E
P
P
S
L
S
P
Site 450
S2891
L
H
I
T
E
P
P
S
L
S
P
D
T
K
L
Site 451
S2893
I
T
E
P
P
S
L
S
P
D
T
K
L
E
P
Site 452
T2896
P
P
S
L
S
P
D
T
K
L
E
P
S
E
D
Site 453
T2918
E
E
M
E
A
S
P
T
E
L
I
A
V
E
G
Site 454
T2936
L
Q
D
F
Q
N
K
T
D
G
Q
V
S
G
E
Site 455
T2972
E
I
E
L
E
G
A
T
Q
W
P
H
S
T
S
Site 456
S2977
G
A
T
Q
W
P
H
S
T
S
A
S
A
T
Y
Site 457
S2981
W
P
H
S
T
S
A
S
A
T
Y
G
V
E
A
Site 458
T2983
H
S
T
S
A
S
A
T
Y
G
V
E
A
G
V
Site 459
S2995
A
G
V
V
P
W
L
S
P
Q
T
S
E
R
P
Site 460
S2999
P
W
L
S
P
Q
T
S
E
R
P
T
L
S
S
Site 461
T3003
P
Q
T
S
E
R
P
T
L
S
S
S
P
E
I
Site 462
S3005
T
S
E
R
P
T
L
S
S
S
P
E
I
N
P
Site 463
S3006
S
E
R
P
T
L
S
S
S
P
E
I
N
P
E
Site 464
S3007
E
R
P
T
L
S
S
S
P
E
I
N
P
E
T
Site 465
T3014
S
P
E
I
N
P
E
T
Q
A
A
L
I
R
G
Site 466
S3024
A
L
I
R
G
Q
D
S
T
I
A
A
S
E
Q
Site 467
T3025
L
I
R
G
Q
D
S
T
I
A
A
S
E
Q
Q
Site 468
T3045
L
D
S
N
D
Q
A
T
V
N
P
V
E
F
N
Site 469
T3057
E
F
N
T
E
V
A
T
P
P
F
S
L
L
E
Site 470
S3061
E
V
A
T
P
P
F
S
L
L
E
T
S
N
E
Site 471
T3065
P
P
F
S
L
L
E
T
S
N
E
T
D
F
L
Site 472
T3083
N
E
E
S
V
E
G
T
A
I
Y
L
P
G
P
Site 473
Y3086
S
V
E
G
T
A
I
Y
L
P
G
P
D
R
C
Site 474
Y3105
C
L
N
G
G
T
C
Y
P
T
E
T
S
Y
V
Site 475
T3114
T
E
T
S
Y
V
C
T
C
V
P
G
Y
S
G
Site 476
T3189
K
Y
F
A
H
R
R
T
W
D
A
A
E
R
E
Site 477
Y3223
V
N
R
V
G
H
D
Y
Q
W
I
G
L
N
D
Site 478
T3240
F
E
H
D
F
R
W
T
D
G
S
T
L
Q
Y
Site 479
Y3247
T
D
G
S
T
L
Q
Y
E
N
W
R
P
N
Q
Site 480
S3257
W
R
P
N
Q
P
D
S
F
F
S
A
G
E
D
Site 481
Y3287
P
C
N
Y
H
L
T
Y
T
C
K
K
G
T
V
Site 482
T3307
P
V
V
E
N
A
K
T
F
G
K
M
K
P
R
Site 483
Y3315
F
G
K
M
K
P
R
Y
E
I
N
S
L
I
R
Site 484
Y3323
E
I
N
S
L
I
R
Y
H
C
K
D
G
F
I
Site 485
T3336
F
I
Q
R
H
L
P
T
I
R
C
L
G
N
G
Site 486
Y3358
T
C
M
N
P
S
A
Y
Q
R
T
Y
S
M
K
Site 487
Y3362
P
S
A
Y
Q
R
T
Y
S
M
K
Y
F
K
N
Site 488
S3363
S
A
Y
Q
R
T
Y
S
M
K
Y
F
K
N
S
Site 489
Y3366
Q
R
T
Y
S
M
K
Y
F
K
N
S
S
S
A
Site 490
S3370
S
M
K
Y
F
K
N
S
S
S
A
K
D
N
S
Site 491
S3372
K
Y
F
K
N
S
S
S
A
K
D
N
S
I
N
Site 492
S3377
S
S
S
A
K
D
N
S
I
N
T
S
K
H
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation