KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ALAS1
Full Name:
5-aminolevulinate synthase, nonspecific, mitochondrial
Alias:
5-aminolevulinate synthase, nonspecific, mitochondrial; ALAS; ALAS3; ALASH; ALAS-H; Aminolevulinate, delta-, synthase 1; HEM1
Type:
Transferase; Amino Acid Metabolism - glycine, serine and threonine; EC 2.3.1.37; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll
Mass (Da):
70580
Number AA:
UniProt ID:
P13196
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0003870
GO:0030170
GO:0016769
PhosphoSite+
KinaseNET
Biological Process:
GO:0006783
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
F
L
Q
K
A
G
K
S
L
L
F
Y
A
Q
N
Site 2
Y29
A
G
K
S
L
L
F
Y
A
Q
N
C
P
K
M
Site 3
S49
K
P
A
P
R
A
L
S
T
A
A
V
H
Y
Q
Site 4
T61
H
Y
Q
Q
I
K
E
T
P
P
A
S
E
K
D
Site 5
S65
I
K
E
T
P
P
A
S
E
K
D
K
T
A
K
Site 6
T70
P
A
S
E
K
D
K
T
A
K
A
K
V
Q
Q
Site 7
T78
A
K
A
K
V
Q
Q
T
P
D
G
S
Q
Q
S
Site 8
S82
V
Q
Q
T
P
D
G
S
Q
Q
S
P
D
G
T
Site 9
S85
T
P
D
G
S
Q
Q
S
P
D
G
T
Q
L
P
Site 10
T89
S
Q
Q
S
P
D
G
T
Q
L
P
S
G
H
P
Site 11
S93
P
D
G
T
Q
L
P
S
G
H
P
L
P
A
T
Site 12
T100
S
G
H
P
L
P
A
T
S
Q
G
T
A
S
K
Site 13
S101
G
H
P
L
P
A
T
S
Q
G
T
A
S
K
C
Site 14
S120
A
Q
M
N
Q
R
G
S
S
V
F
C
K
A
S
Site 15
S121
Q
M
N
Q
R
G
S
S
V
F
C
K
A
S
L
Site 16
S127
S
S
V
F
C
K
A
S
L
E
L
Q
E
D
V
Site 17
T147
V
R
K
E
V
A
E
T
S
A
G
P
S
V
V
Site 18
S148
R
K
E
V
A
E
T
S
A
G
P
S
V
V
S
Site 19
S152
A
E
T
S
A
G
P
S
V
V
S
V
K
T
D
Site 20
S155
S
A
G
P
S
V
V
S
V
K
T
D
G
G
D
Site 21
T158
P
S
V
V
S
V
K
T
D
G
G
D
P
S
G
Site 22
S164
K
T
D
G
G
D
P
S
G
L
L
K
N
F
Q
Site 23
S183
K
Q
R
P
E
R
V
S
H
L
L
Q
D
N
L
Site 24
S193
L
Q
D
N
L
P
K
S
V
S
T
F
Q
Y
D
Site 25
S195
D
N
L
P
K
S
V
S
T
F
Q
Y
D
R
F
Site 26
Y199
K
S
V
S
T
F
Q
Y
D
R
F
F
E
K
K
Site 27
T215
D
E
K
K
N
D
H
T
Y
R
V
F
K
T
V
Site 28
Y216
E
K
K
N
D
H
T
Y
R
V
F
K
T
V
N
Site 29
Y235
I
F
P
M
A
D
D
Y
S
D
S
L
I
T
K
Site 30
S236
F
P
M
A
D
D
Y
S
D
S
L
I
T
K
K
Site 31
S238
M
A
D
D
Y
S
D
S
L
I
T
K
K
Q
V
Site 32
Y253
S
V
W
C
S
N
D
Y
L
G
M
S
R
H
P
Site 33
T280
H
G
A
G
A
G
G
T
R
N
I
S
G
T
S
Site 34
S284
A
G
G
T
R
N
I
S
G
T
S
K
F
H
V
Site 35
T286
G
T
R
N
I
S
G
T
S
K
F
H
V
D
L
Site 36
S287
T
R
N
I
S
G
T
S
K
F
H
V
D
L
E
Site 37
Y333
M
M
P
G
C
E
I
Y
S
D
S
G
N
H
A
Site 38
S341
S
D
S
G
N
H
A
S
M
I
Q
G
I
R
N
Site 39
Y354
R
N
S
R
V
P
K
Y
I
F
R
H
N
D
V
Site 40
S362
I
F
R
H
N
D
V
S
H
L
R
E
L
L
Q
Site 41
S371
L
R
E
L
L
Q
R
S
D
P
S
V
P
K
I
Site 42
T463
S
T
S
S
L
I
D
T
V
R
S
Y
A
A
G
Site 43
S494
E
S
V
R
I
L
K
S
A
E
G
R
V
L
R
Site 44
Y554
L
M
S
R
H
N
I
Y
V
Q
A
I
N
Y
P
Site 45
Y560
I
Y
V
Q
A
I
N
Y
P
T
V
P
R
G
E
Site 46
T575
E
L
L
R
I
A
P
T
P
H
H
T
P
Q
M
Site 47
S606
L
E
L
K
P
H
S
S
A
E
C
N
F
C
R
Site 48
S622
P
L
H
F
E
V
M
S
E
R
E
K
S
Y
F
Site 49
S627
V
M
S
E
R
E
K
S
Y
F
S
G
L
S
K
Site 50
Y628
M
S
E
R
E
K
S
Y
F
S
G
L
S
K
L
Site 51
S630
E
R
E
K
S
Y
F
S
G
L
S
K
L
V
S
Site 52
S633
K
S
Y
F
S
G
L
S
K
L
V
S
A
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation