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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Peptidase D
Full Name:
Xaa-Pro dipeptidase
Alias:
Imidodipeptidase;Peptidase D;Proline dipeptidase
Type:
Mass (Da):
54417
Number AA:
492
UniProt ID:
P12955
International Prot ID:
IPI00257882
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0016805
GO:0030145
PhosphoSite+
KinaseNET
Biological Process:
GO:0006520
GO:0030574
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y57
G
G
E
E
T
Q
R
Y
C
T
D
T
G
V
L
Site 2
T59
E
E
T
Q
R
Y
C
T
D
T
G
V
L
F
R
Site 3
T61
T
Q
R
Y
C
T
D
T
G
V
L
F
R
Q
E
Site 4
S103
F
V
P
R
L
P
A
S
H
A
T
W
M
G
K
Site 5
Y121
K
E
H
F
K
E
K
Y
A
V
D
D
V
Q
Y
Site 6
Y128
Y
A
V
D
D
V
Q
Y
V
D
E
I
A
S
V
Site 7
T146
Q
K
P
S
V
L
L
T
L
R
G
V
N
T
D
Site 8
T152
L
T
L
R
G
V
N
T
D
S
G
S
V
C
R
Site 9
S154
L
R
G
V
N
T
D
S
G
S
V
C
R
E
A
Site 10
S156
G
V
N
T
D
S
G
S
V
C
R
E
A
S
F
Site 11
S162
G
S
V
C
R
E
A
S
F
D
G
I
S
K
F
Site 12
T174
S
K
F
E
V
N
N
T
I
L
H
P
E
I
V
Site 13
T188
V
E
C
R
V
F
K
T
D
M
E
L
E
V
L
Site 14
Y197
M
E
L
E
V
L
R
Y
T
N
K
I
S
S
E
Site 15
T198
E
L
E
V
L
R
Y
T
N
K
I
S
S
E
A
Site 16
Y220
V
K
V
G
M
K
E
Y
E
L
E
S
L
F
E
Site 17
Y229
L
E
S
L
F
E
H
Y
C
Y
S
R
G
G
M
Site 18
Y231
S
L
F
E
H
Y
C
Y
S
R
G
G
M
R
H
Site 19
S240
R
G
G
M
R
H
S
S
Y
T
C
I
C
G
S
Site 20
Y241
G
G
M
R
H
S
S
Y
T
C
I
C
G
S
G
Site 21
T266
A
G
A
P
N
D
R
T
I
Q
N
G
D
M
C
Site 22
Y282
F
D
M
G
G
E
Y
Y
C
F
A
S
D
I
T
Site 23
Y306
T
A
D
Q
K
A
V
Y
E
A
V
L
R
S
S
Site 24
Y382
D
V
H
D
V
G
G
Y
P
E
G
V
E
R
I
Site 25
S396
I
D
E
P
G
L
R
S
L
R
T
A
R
H
L
Site 26
T399
P
G
L
R
S
L
R
T
A
R
H
L
Q
P
G
Site 27
T487
A
G
C
D
K
A
F
T
P
F
S
G
P
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation