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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYH7
Full Name:
Myosin-7
Alias:
CMD1S; CMH1; MPD1; MYHCB; MyHC-beta; Myosin heavy chain, cardiac muscle beta; Myosin, heavy chain 7, cardiac muscle, beta
Type:
Motor protein
Mass (Da):
223097
Number AA:
1935
UniProt ID:
P12883
International Prot ID:
IPI00025880
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005925
GO:0005859
GO:0032982
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0030898
PhosphoSite+
KinaseNET
Biological Process:
GO:0006200
GO:0007512
GO:0030049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
G
D
S
E
M
A
V
F
G
A
Site 2
Y15
V
F
G
A
A
A
P
Y
L
R
K
S
E
K
E
Site 3
S19
A
A
P
Y
L
R
K
S
E
K
E
R
L
E
A
Site 4
T60
S
R
E
G
G
K
V
T
A
E
T
E
Y
G
K
Site 5
T63
G
G
K
V
T
A
E
T
E
Y
G
K
T
V
T
Site 6
Y65
K
V
T
A
E
T
E
Y
G
K
T
V
T
V
K
Site 7
T68
A
E
T
E
Y
G
K
T
V
T
V
K
E
D
Q
Site 8
Y103
L
H
E
P
A
V
L
Y
N
L
K
D
R
Y
G
Site 9
Y109
L
Y
N
L
K
D
R
Y
G
S
W
M
I
Y
T
Site 10
S148
A
Y
R
G
K
K
R
S
E
A
P
P
H
I
F
Site 11
S156
E
A
P
P
H
I
F
S
I
S
D
N
A
Y
Q
Site 12
Y162
F
S
I
S
D
N
A
Y
Q
Y
M
L
T
D
R
Site 13
Y164
I
S
D
N
A
Y
Q
Y
M
L
T
D
R
E
N
Site 14
T167
N
A
Y
Q
Y
M
L
T
D
R
E
N
Q
S
I
Site 15
S173
L
T
D
R
E
N
Q
S
I
L
I
T
G
E
S
Site 16
T177
E
N
Q
S
I
L
I
T
G
E
S
G
A
G
K
Site 17
T185
G
E
S
G
A
G
K
T
V
N
T
K
R
V
I
Site 18
T188
G
A
G
K
T
V
N
T
K
R
V
I
Q
Y
F
Site 19
S205
I
A
A
I
G
D
R
S
K
K
D
Q
S
P
G
Site 20
S210
D
R
S
K
K
D
Q
S
P
G
K
G
T
L
E
Site 21
T235
E
A
F
G
N
A
K
T
V
R
N
D
N
S
S
Site 22
S241
K
T
V
R
N
D
N
S
S
R
F
G
K
F
I
Site 23
S242
T
V
R
N
D
N
S
S
R
F
G
K
F
I
R
Site 24
Y266
A
S
A
D
I
E
T
Y
L
L
E
K
S
R
V
Site 25
S271
E
T
Y
L
L
E
K
S
R
V
I
F
Q
L
K
Site 26
Y283
Q
L
K
A
E
R
D
Y
H
I
F
Y
Q
I
L
Site 27
Y287
E
R
D
Y
H
I
F
Y
Q
I
L
S
N
K
K
Site 28
S291
H
I
F
Y
Q
I
L
S
N
K
K
P
E
L
L
Site 29
Y310
I
T
N
N
P
Y
D
Y
A
F
I
S
Q
G
E
Site 30
S314
P
Y
D
Y
A
F
I
S
Q
G
E
T
T
V
A
Site 31
S322
Q
G
E
T
T
V
A
S
I
D
D
A
E
E
L
Site 32
T332
D
A
E
E
L
M
A
T
D
N
A
F
D
V
L
Site 33
S343
F
D
V
L
G
F
T
S
E
E
K
N
S
M
Y
Site 34
Y350
S
E
E
K
N
S
M
Y
K
L
T
G
A
I
M
Site 35
T378
E
Q
A
E
P
D
G
T
E
E
A
D
K
S
A
Site 36
S384
G
T
E
E
A
D
K
S
A
Y
L
M
G
L
N
Site 37
Y386
E
E
A
D
K
S
A
Y
L
M
G
L
N
S
A
Site 38
Y410
R
V
K
V
G
N
E
Y
V
T
K
G
Q
N
V
Site 39
T412
K
V
G
N
E
Y
V
T
K
G
Q
N
V
Q
Q
Site 40
Y422
Q
N
V
Q
Q
V
I
Y
A
T
G
A
L
A
K
Site 41
T441
R
M
F
N
W
M
V
T
R
I
N
A
T
L
E
Site 42
T446
M
V
T
R
I
N
A
T
L
E
T
K
Q
P
R
Site 43
T449
R
I
N
A
T
L
E
T
K
Q
P
R
Q
Y
F
Site 44
Y455
E
T
K
Q
P
R
Q
Y
F
I
G
V
L
D
I
Site 45
T481
E
Q
L
C
I
N
F
T
N
E
K
L
Q
Q
F
Site 46
Y501
F
V
L
E
Q
E
E
Y
K
K
E
G
I
E
W
Site 47
T547
F
P
K
A
T
D
M
T
F
K
A
K
L
F
D
Site 48
S560
F
D
N
H
L
G
K
S
A
N
F
Q
K
P
R
Site 49
S578
G
K
P
E
A
H
F
S
L
I
H
Y
A
G
I
Site 50
Y582
A
H
F
S
L
I
H
Y
A
G
I
V
D
Y
N
Site 51
Y588
H
Y
A
G
I
V
D
Y
N
I
I
G
W
L
Q
Site 52
T604
N
K
D
P
L
N
E
T
V
V
G
L
Y
Q
K
Site 53
Y609
N
E
T
V
V
G
L
Y
Q
K
S
S
L
K
L
Site 54
Y624
L
S
T
L
F
A
N
Y
A
G
A
D
A
P
I
Site 55
S643
G
K
A
K
K
G
S
S
F
Q
T
V
S
A
L
Site 56
T646
K
K
G
S
S
F
Q
T
V
S
A
L
H
R
E
Site 57
T660
E
N
L
N
K
L
M
T
N
L
R
S
T
H
P
Site 58
T665
L
M
T
N
L
R
S
T
H
P
H
F
V
R
C
Site 59
S680
I
I
P
N
E
T
K
S
P
G
V
M
D
N
P
Site 60
Y715
G
F
P
N
R
I
L
Y
G
D
F
R
Q
R
Y
Site 61
Y722
Y
G
D
F
R
Q
R
Y
R
I
L
N
P
A
A
Site 62
S747
K
G
A
E
K
L
L
S
S
L
D
I
D
H
N
Site 63
Y756
L
D
I
D
H
N
Q
Y
K
F
G
H
T
K
V
Site 64
S782
E
M
R
D
E
R
L
S
R
I
I
T
R
I
Q
Site 65
T786
E
R
L
S
R
I
I
T
R
I
Q
A
Q
S
R
Site 66
S792
I
T
R
I
Q
A
Q
S
R
G
V
L
A
R
M
Site 67
Y801
G
V
L
A
R
M
E
Y
K
K
L
L
E
R
R
Site 68
S810
K
L
L
E
R
R
D
S
L
L
V
I
Q
W
N
Site 69
Y833
N
W
P
W
M
K
L
Y
F
K
I
K
P
L
L
Site 70
S842
K
I
K
P
L
L
K
S
A
E
R
E
K
E
M
Site 71
S851
E
R
E
K
E
M
A
S
M
K
E
E
F
T
R
Site 72
S866
L
K
E
A
L
E
K
S
E
A
R
R
K
E
L
Site 73
S879
E
L
E
E
K
M
V
S
L
L
Q
E
K
N
D
Site 74
S948
R
K
L
E
D
E
C
S
E
L
K
R
D
I
D
Site 75
T960
D
I
D
D
L
E
L
T
L
A
K
V
E
K
E
Site 76
T971
V
E
K
E
K
H
A
T
E
N
K
V
K
N
L
Site 77
S1037
Q
V
D
D
L
E
G
S
L
E
Q
E
K
K
V
Site 78
S1102
E
D
E
Q
A
L
G
S
Q
L
Q
K
K
L
K
Site 79
T1127
E
E
L
E
A
E
R
T
A
R
A
K
V
E
K
Site 80
S1137
A
K
V
E
K
L
R
S
D
L
S
R
E
L
E
Site 81
S1140
E
K
L
R
S
D
L
S
R
E
L
E
E
I
S
Site 82
S1147
S
R
E
L
E
E
I
S
E
R
L
E
E
A
G
Site 83
S1158
E
E
A
G
G
A
T
S
V
Q
I
E
M
N
K
Site 84
S1199
L
R
K
K
H
A
D
S
V
A
E
L
G
E
Q
Site 85
S1222
Q
K
L
E
K
E
K
S
E
F
K
L
E
L
D
Site 86
T1232
K
L
E
L
D
D
V
T
S
N
M
E
Q
I
I
Site 87
S1233
L
E
L
D
D
V
T
S
N
M
E
Q
I
I
K
Site 88
S1269
K
A
E
E
T
Q
R
S
V
N
D
L
T
S
Q
Site 89
T1274
Q
R
S
V
N
D
L
T
S
Q
R
A
K
L
Q
Site 90
S1275
R
S
V
N
D
L
T
S
Q
R
A
K
L
Q
T
Site 91
T1282
S
Q
R
A
K
L
Q
T
E
N
G
E
L
S
R
Site 92
S1299
D
E
K
E
A
L
I
S
Q
L
T
R
G
K
L
Site 93
T1307
Q
L
T
R
G
K
L
T
Y
T
Q
Q
L
E
D
Site 94
Y1308
L
T
R
G
K
L
T
Y
T
Q
Q
L
E
D
L
Site 95
T1309
T
R
G
K
L
T
Y
T
Q
Q
L
E
D
L
K
Site 96
S1335
A
L
A
H
A
L
Q
S
A
R
H
D
C
D
L
Site 97
Y1347
C
D
L
L
R
E
Q
Y
E
E
E
T
E
A
K
Site 98
T1351
R
E
Q
Y
E
E
E
T
E
A
K
A
E
L
Q
Site 99
S1362
A
E
L
Q
R
V
L
S
K
A
N
S
E
V
A
Site 100
S1366
R
V
L
S
K
A
N
S
E
V
A
Q
W
R
T
Site 101
T1373
S
E
V
A
Q
W
R
T
K
Y
E
T
D
A
I
Site 102
Y1375
V
A
Q
W
R
T
K
Y
E
T
D
A
I
Q
R
Site 103
T1377
Q
W
R
T
K
Y
E
T
D
A
I
Q
R
T
E
Site 104
T1383
E
T
D
A
I
Q
R
T
E
E
L
E
E
A
K
Site 105
S1413
A
V
N
A
K
C
S
S
L
E
K
T
K
H
R
Site 106
T1417
K
C
S
S
L
E
K
T
K
H
R
L
Q
N
E
Site 107
Y1460
L
A
E
W
K
Q
K
Y
E
E
S
Q
S
E
L
Site 108
S1463
W
K
Q
K
Y
E
E
S
Q
S
E
L
E
S
S
Site 109
S1465
Q
K
Y
E
E
S
Q
S
E
L
E
S
S
Q
K
Site 110
S1469
E
S
Q
S
E
L
E
S
S
Q
K
E
A
R
S
Site 111
S1470
S
Q
S
E
L
E
S
S
Q
K
E
A
R
S
L
Site 112
S1476
S
S
Q
K
E
A
R
S
L
S
T
E
L
F
K
Site 113
S1478
Q
K
E
A
R
S
L
S
T
E
L
F
K
L
K
Site 114
Y1488
L
F
K
L
K
N
A
Y
E
E
S
L
E
H
L
Site 115
S1491
L
K
N
A
Y
E
E
S
L
E
H
L
E
T
F
Site 116
T1497
E
S
L
E
H
L
E
T
F
K
R
E
N
K
N
Site 117
S1510
K
N
L
Q
E
E
I
S
D
L
T
E
Q
L
G
Site 118
T1513
Q
E
E
I
S
D
L
T
E
Q
L
G
S
S
G
Site 119
S1518
D
L
T
E
Q
L
G
S
S
G
K
T
I
H
E
Site 120
T1522
Q
L
G
S
S
G
K
T
I
H
E
L
E
K
V
Site 121
S1550
A
L
E
E
A
E
A
S
L
E
H
E
E
G
K
Site 122
S1596
N
H
L
R
V
V
D
S
L
Q
T
S
L
D
A
Site 123
S1600
V
V
D
S
L
Q
T
S
L
D
A
E
T
R
S
Site 124
S1607
S
L
D
A
E
T
R
S
R
N
E
A
L
R
V
Site 125
S1645
E
A
Q
K
Q
V
K
S
L
Q
S
L
L
K
D
Site 126
T1709
A
E
Q
E
L
I
E
T
S
E
R
V
Q
L
L
Site 127
S1710
E
Q
E
L
I
E
T
S
E
R
V
Q
L
L
H
Site 128
S1718
E
R
V
Q
L
L
H
S
Q
N
T
S
L
I
N
Site 129
S1722
L
L
H
S
Q
N
T
S
L
I
N
Q
K
K
K
Site 130
S1735
K
K
M
D
A
D
L
S
Q
L
Q
T
E
V
E
Site 131
T1739
A
D
L
S
Q
L
Q
T
E
V
E
E
A
V
Q
Site 132
S1776
L
K
K
E
Q
D
T
S
A
H
L
E
R
M
K
Site 133
S1843
S
V
K
G
M
R
K
S
E
R
R
I
K
E
L
Site 134
T1851
E
R
R
I
K
E
L
T
Y
Q
T
E
E
D
R
Site 135
Y1852
R
R
I
K
E
L
T
Y
Q
T
E
E
D
R
K
Site 136
T1854
I
K
E
L
T
Y
Q
T
E
E
D
R
K
N
L
Site 137
Y1878
L
Q
L
K
V
K
A
Y
K
R
Q
A
E
E
A
Site 138
T1891
E
A
E
E
Q
A
N
T
N
L
S
K
F
R
K
Site 139
S1915
E
R
A
D
I
A
E
S
Q
V
N
K
L
R
A
Site 140
S1924
V
N
K
L
R
A
K
S
R
D
I
G
T
K
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation