KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MYH1
Full Name:
Myosin-1
Alias:
MGC133384; MYHa; MyHC-2X/D; MyHC-IIx/d; MYHSA1; Myosin heavy chain 1; Myosin heavy chain 2x; Myosin heavy chain IIx/d; Myosin heavy chain, skeletal muscle, adult 1; Myosin, heavy chain 1, skeletal muscle, adult
Type:
Motor protein
Mass (Da):
223145
Number AA:
1939
UniProt ID:
P12882
International Prot ID:
IPI00025879
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005925
GO:0005859
GO:0032982
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
D
S
E
M
A
I
Site 2
S3
_
_
_
_
_
M
S
S
D
S
E
M
A
I
F
Site 3
S20
A
A
P
F
L
R
K
S
E
R
E
R
I
E
A
Site 4
T36
N
K
P
F
D
A
K
T
S
V
F
V
V
D
P
Site 5
T51
K
E
S
F
V
K
A
T
V
Q
S
R
E
G
G
Site 6
T64
G
G
K
V
T
A
K
T
E
A
G
A
T
V
T
Site 7
T69
A
K
T
E
A
G
A
T
V
T
V
K
D
D
Q
Site 8
Y85
F
P
M
N
P
P
K
Y
D
K
I
E
D
M
A
Site 9
Y104
L
H
E
P
A
V
L
Y
N
L
K
E
R
Y
A
Site 10
S157
E
A
P
P
H
I
F
S
I
S
D
N
A
Y
Q
Site 11
Y163
F
S
I
S
D
N
A
Y
Q
F
M
L
T
D
R
Site 12
T168
N
A
Y
Q
F
M
L
T
D
R
E
N
Q
S
I
Site 13
T178
E
N
Q
S
I
L
I
T
G
E
S
G
A
G
K
Site 14
T186
G
E
S
G
A
G
K
T
V
N
T
K
R
V
I
Site 15
T189
G
A
G
K
T
V
N
T
K
R
V
I
Q
Y
F
Site 16
T198
R
V
I
Q
Y
F
A
T
I
A
V
T
G
E
K
Site 17
S212
K
K
K
E
E
V
T
S
G
K
M
Q
G
T
L
Site 18
T218
T
S
G
K
M
Q
G
T
L
E
D
Q
I
I
S
Site 19
T238
E
A
F
G
N
A
K
T
V
R
N
D
N
S
S
Site 20
S244
K
T
V
R
N
D
N
S
S
R
F
G
K
F
I
Site 21
S245
T
V
R
N
D
N
S
S
R
F
G
K
F
I
R
Site 22
S263
G
T
T
G
K
L
A
S
A
D
I
E
T
Y
L
Site 23
Y269
A
S
A
D
I
E
T
Y
L
L
E
K
S
R
V
Site 24
S274
E
T
Y
L
L
E
K
S
R
V
T
F
Q
L
K
Site 25
T277
L
L
E
K
S
R
V
T
F
Q
L
K
A
E
R
Site 26
Y286
Q
L
K
A
E
R
S
Y
H
I
F
Y
Q
I
M
Site 27
Y290
E
R
S
Y
H
I
F
Y
Q
I
M
S
N
K
K
Site 28
Y313
I
T
T
N
P
Y
D
Y
A
F
V
S
Q
G
E
Site 29
S317
P
Y
D
Y
A
F
V
S
Q
G
E
I
T
V
P
Site 30
S325
Q
G
E
I
T
V
P
S
I
D
D
Q
E
E
L
Site 31
T335
D
Q
E
E
L
M
A
T
D
S
A
I
E
I
L
Site 32
S351
F
T
S
D
E
R
V
S
I
Y
K
L
T
G
A
Site 33
Y353
S
D
E
R
V
S
I
Y
K
L
T
G
A
V
M
Site 34
T356
R
V
S
I
Y
K
L
T
G
A
V
M
H
Y
G
Site 35
Y362
L
T
G
A
V
M
H
Y
G
N
M
K
F
K
Q
Site 36
T381
E
Q
A
E
P
D
G
T
E
V
A
D
K
A
A
Site 37
Y389
E
V
A
D
K
A
A
Y
L
Q
N
L
N
S
A
Site 38
Y404
D
L
L
K
A
L
C
Y
P
R
V
K
V
G
N
Site 39
Y413
R
V
K
V
G
N
E
Y
V
T
K
G
Q
T
V
Site 40
T415
K
V
G
N
E
Y
V
T
K
G
Q
T
V
Q
Q
Site 41
Y424
G
Q
T
V
Q
Q
V
Y
N
A
V
G
A
L
A
Site 42
T452
R
I
N
Q
Q
L
D
T
K
Q
P
R
Q
Y
F
Site 43
Y458
D
T
K
Q
P
R
Q
Y
F
I
G
V
L
D
I
Site 44
T484
E
Q
L
C
I
N
F
T
N
E
K
L
Q
Q
F
Site 45
Y504
F
V
L
E
Q
E
E
Y
K
K
E
G
I
E
W
Site 46
S535
E
K
P
M
G
I
F
S
I
L
E
E
E
C
M
Site 47
S550
F
P
K
A
T
D
T
S
F
K
N
K
L
Y
E
Site 48
Y556
T
S
F
K
N
K
L
Y
E
Q
H
L
G
K
S
Site 49
S581
G
K
P
E
A
H
F
S
L
I
H
Y
A
G
T
Site 50
Y585
A
H
F
S
L
I
H
Y
A
G
T
V
D
Y
N
Site 51
Y591
H
Y
A
G
T
V
D
Y
N
I
A
G
W
L
D
Site 52
T607
N
K
D
P
L
N
E
T
V
V
G
L
Y
Q
K
Site 53
Y612
N
E
T
V
V
G
L
Y
Q
K
S
A
M
K
T
Site 54
S646
K
G
G
K
K
K
G
S
S
F
Q
T
V
S
A
Site 55
S647
G
G
K
K
K
G
S
S
F
Q
T
V
S
A
L
Site 56
T650
K
K
G
S
S
F
Q
T
V
S
A
L
F
R
E
Site 57
T664
E
N
L
N
K
L
M
T
N
L
R
S
T
H
P
Site 58
T669
L
M
T
N
L
R
S
T
H
P
H
F
V
R
C
Site 59
T684
I
I
P
N
E
T
K
T
P
G
A
M
E
H
E
Site 60
Y719
G
F
P
S
R
I
L
Y
A
D
F
K
Q
R
Y
Site 61
Y726
Y
A
D
F
K
Q
R
Y
K
V
L
N
A
S
A
Site 62
S742
P
E
G
Q
F
I
D
S
K
K
A
S
E
K
L
Site 63
S746
F
I
D
S
K
K
A
S
E
K
L
L
G
S
I
Site 64
S752
A
S
E
K
L
L
G
S
I
D
I
D
H
T
Q
Site 65
T758
G
S
I
D
I
D
H
T
Q
Y
K
F
G
H
T
Site 66
Y805
G
F
L
A
R
V
E
Y
Q
K
M
V
E
R
R
Site 67
Y820
E
S
I
F
C
I
Q
Y
N
V
R
A
F
M
N
Site 68
S846
K
I
K
P
L
L
K
S
A
E
T
E
K
E
M
Site 69
T863
M
K
E
E
F
E
K
T
K
E
E
L
A
K
T
Site 70
T870
T
K
E
E
L
A
K
T
E
A
K
R
K
E
L
Site 71
T883
E
L
E
E
K
M
V
T
L
M
Q
E
K
N
D
Site 72
S901
Q
V
Q
A
E
A
D
S
L
A
D
A
E
E
R
Site 73
S952
R
K
L
E
D
E
C
S
E
L
K
K
D
I
D
Site 74
T964
D
I
D
D
L
E
L
T
L
A
K
V
E
K
E
Site 75
T975
V
E
K
E
K
H
A
T
E
N
K
V
K
N
L
Site 76
T992
E
M
A
G
L
D
E
T
I
A
K
L
T
K
E
Site 77
S1041
Q
V
D
D
L
E
G
S
L
E
Q
E
K
K
I
Site 78
S1092
K
K
K
E
F
E
M
S
G
L
Q
S
K
I
E
Site 79
S1096
F
E
M
S
G
L
Q
S
K
I
E
D
E
Q
A
Site 80
S1132
E
I
E
A
E
R
A
S
R
A
K
A
E
K
Q
Site 81
S1141
A
K
A
E
K
Q
R
S
D
L
S
R
E
L
E
Site 82
S1144
E
K
Q
R
S
D
L
S
R
E
L
E
E
I
S
Site 83
S1151
S
R
E
L
E
E
I
S
E
R
L
E
E
A
G
Site 84
S1162
E
E
A
G
G
A
T
S
A
Q
I
E
M
N
K
Site 85
T1192
A
T
L
Q
H
E
A
T
A
A
T
L
R
K
K
Site 86
T1195
Q
H
E
A
T
A
A
T
L
R
K
K
H
A
D
Site 87
S1203
L
R
K
K
H
A
D
S
V
A
E
L
G
E
Q
Site 88
S1226
Q
K
L
E
K
E
K
S
E
M
K
M
E
I
D
Site 89
S1237
M
E
I
D
D
L
A
S
N
M
E
T
V
S
K
Site 90
T1241
D
L
A
S
N
M
E
T
V
S
K
A
K
G
N
Site 91
S1243
A
S
N
M
E
T
V
S
K
A
K
G
N
L
E
Site 92
S1261
R
A
L
E
D
Q
L
S
E
I
K
T
K
E
E
Site 93
T1265
D
Q
L
S
E
I
K
T
K
E
E
E
Q
Q
R
Site 94
T1278
Q
R
L
I
N
D
L
T
A
Q
R
A
R
L
Q
Site 95
T1286
A
Q
R
A
R
L
Q
T
E
S
G
E
Y
S
R
Site 96
S1288
R
A
R
L
Q
T
E
S
G
E
Y
S
R
Q
L
Site 97
Y1291
L
Q
T
E
S
G
E
Y
S
R
Q
L
D
E
K
Site 98
S1292
Q
T
E
S
G
E
Y
S
R
Q
L
D
E
K
D
Site 99
T1300
R
Q
L
D
E
K
D
T
L
V
S
Q
L
S
R
Site 100
S1303
D
E
K
D
T
L
V
S
Q
L
S
R
G
K
Q
Site 101
S1339
A
L
A
H
A
L
Q
S
S
R
H
D
C
D
L
Site 102
Y1351
C
D
L
L
R
E
Q
Y
E
E
E
Q
E
A
K
Site 103
S1366
A
E
L
Q
R
A
M
S
K
A
N
S
E
V
A
Site 104
S1370
R
A
M
S
K
A
N
S
E
V
A
Q
W
R
T
Site 105
T1377
S
E
V
A
Q
W
R
T
K
Y
E
T
D
A
I
Site 106
Y1379
V
A
Q
W
R
T
K
Y
E
T
D
A
I
Q
R
Site 107
T1381
Q
W
R
T
K
Y
E
T
D
A
I
Q
R
T
E
Site 108
T1387
E
T
D
A
I
Q
R
T
E
E
L
E
E
A
K
Site 109
S1417
A
V
N
A
K
C
A
S
L
E
K
T
K
Q
R
Site 110
T1421
K
C
A
S
L
E
K
T
K
Q
R
L
Q
N
E
Site 111
S1474
T
H
A
E
L
E
A
S
Q
K
E
S
R
S
L
Site 112
S1478
L
E
A
S
Q
K
E
S
R
S
L
S
T
E
L
Site 113
S1480
A
S
Q
K
E
S
R
S
L
S
T
E
L
F
K
Site 114
S1482
Q
K
E
S
R
S
L
S
T
E
L
F
K
I
K
Site 115
Y1492
L
F
K
I
K
N
A
Y
E
E
S
L
D
Q
L
Site 116
S1495
I
K
N
A
Y
E
E
S
L
D
Q
L
E
T
L
Site 117
T1501
E
S
L
D
Q
L
E
T
L
K
R
E
N
K
N
Site 118
S1514
K
N
L
Q
Q
E
I
S
D
L
T
E
Q
I
A
Site 119
T1517
Q
Q
E
I
S
D
L
T
E
Q
I
A
E
G
G
Site 120
S1542
K
Q
V
E
Q
E
K
S
E
L
Q
A
A
L
E
Site 121
S1554
A
L
E
E
A
E
A
S
L
E
H
E
E
G
K
Site 122
S1574
L
E
L
N
Q
V
K
S
E
V
D
R
K
I
A
Site 123
S1600
N
H
I
R
I
V
E
S
M
Q
S
T
L
D
A
Site 124
S1603
R
I
V
E
S
M
Q
S
T
L
D
A
E
I
R
Site 125
T1604
I
V
E
S
M
Q
S
T
L
D
A
E
I
R
S
Site 126
Y1647
A
A
E
A
L
R
N
Y
R
N
T
Q
A
I
L
Site 127
T1650
A
L
R
N
Y
R
N
T
Q
A
I
L
K
D
T
Site 128
S1667
H
L
D
D
A
L
R
S
Q
E
D
L
K
E
Q
Site 129
T1695
E
I
E
E
L
R
A
T
L
E
Q
T
E
R
S
Site 130
T1699
L
R
A
T
L
E
Q
T
E
R
S
R
K
I
A
Site 131
S1714
E
Q
E
L
L
D
A
S
E
R
V
Q
L
L
H
Site 132
T1722
E
R
V
Q
L
L
H
T
Q
N
T
S
L
I
N
Site 133
S1726
L
L
H
T
Q
N
T
S
L
I
N
T
K
K
K
Site 134
S1739
K
K
L
E
T
D
I
S
Q
I
Q
G
E
M
E
Site 135
S1780
L
K
K
E
Q
D
T
S
A
H
L
E
R
M
K
Site 136
T1793
M
K
K
N
L
E
Q
T
V
K
D
L
Q
H
R
Site 137
T1855
E
R
K
V
K
E
L
T
Y
Q
T
E
E
D
R
Site 138
Y1856
R
K
V
K
E
L
T
Y
Q
T
E
E
D
R
K
Site 139
S1881
K
L
Q
A
K
V
K
S
Y
K
R
Q
A
E
E
Site 140
S1898
E
Q
S
N
V
N
L
S
K
F
R
R
I
Q
H
Site 141
S1919
E
R
A
D
I
A
E
S
Q
V
N
K
L
R
V
Site 142
S1928
V
N
K
L
R
V
K
S
R
E
V
H
T
K
I
Site 143
T1933
V
K
S
R
E
V
H
T
K
I
I
S
E
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation