PhosphoNET

           
Protein Info 
   
Short Name:  CYP2C9
Full Name:  Cytochrome P450 2C9
Alias:  CP2C9; CP2CT; CPC9; CYP2C; CYP2C10; CYPIIC9; Cytochrome P-450 S-mephenytoin 4-hydroxylase; EC 1.14.13.48; EC 1.14.13.49; EC 1.14.13.80; EC 1.14.14.1; P450 MP-4; P450 MP-4/MP-8; P450 PB-1; P450IIC9; P-450MP; S-mephenytoin 4-hydroxylase
Type:  Membrane, Microsome, Endoplasmic reticulum membrane protein
Mass (Da):  55628
Number AA:  490
UniProt ID:  P11712
International Prot ID:  IPI00007219
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005789  GO:0019898  GO:0005792 Uniprot OncoNet
Molecular Function:  GO:0018675  GO:0018676  GO:0033767 PhosphoSite+ KinaseNET
Biological Process:  GO:0017144  GO:0016098  GO:0055114 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S23LLSLWRQSSGRGKLP
Site 2S24LSLWRQSSGRGKLPP
Site 3T34GKLPPGPTPLPVIGN
Site 4S51QIGIKDISKSLTNLS
Site 5S53GIKDISKSLTNLSKV
Site 6T55KDISKSLTNLSKVYG
Site 7S58SKSLTNLSKVYGPVF
Site 8Y61LTNLSKVYGPVFTLY
Site 9S115RGFGIVFSNGKKWKE
Site 10S127WKEIRRFSLMTLRNF
Site 11S140NFGMGKRSIEDRVQE
Site 12T159LVEELRKTKASPCDP
Site 13S162ELRKTKASPCDPTFI
Site 14Y189IFHKRFDYKDQQFLN
Site 15Y225NFSPIIDYFPGTHNK
Site 16T229IIDYFPGTHNKLLKN
Site 17S242KNVAFMKSYILEKVK
Site 18S286PSEFTIESLENTAVD
Site 19T301LFGAGTETTSTTLRY
Site 20T304AGTETTSTTLRYALL
Site 21S336RVIGRNRSPCMQDRS
Site 22Y347QDRSHMPYTDAVVHE
Site 23T348DRSHMPYTDAVVHEV
Site 24Y379CDIKFRNYLIPKGTT
Site 25Y424GNFKKSKYFMPFSAG
Site 26S460LQNFNLKSLVDPKNL
Site 27T469VDPKNLDTTPVVNGF
Site 28T470DPKNLDTTPVVNGFA
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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