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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP2A6
Full Name:
Cytochrome P450 2A6
Alias:
Coumarin 7-hydroxylase; CYP2A3; CYPIIA6; P450 IIA3; P450(I)
Type:
Endoplasmic reticulum membrane, Peripheral membrane, Microsome membrane protein
Mass (Da):
56517
Number AA:
494
UniProt ID:
P11509
International Prot ID:
IPI00299568
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0019898
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0070330
GO:0008389
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
S
V
W
Q
Q
R
K
S
K
G
K
L
P
P
G
Site 2
T38
G
K
L
P
P
G
P
T
P
L
P
F
I
G
N
Site 3
Y46
P
L
P
F
I
G
N
Y
L
Q
L
N
T
E
Q
Site 4
S57
N
T
E
Q
M
Y
N
S
L
M
K
I
S
E
R
Site 5
S62
Y
N
S
L
M
K
I
S
E
R
Y
G
P
V
F
Site 6
S99
V
D
Q
A
E
E
F
S
G
R
G
E
Q
A
T
Site 7
T106
S
G
R
G
E
Q
A
T
F
D
W
V
F
K
G
Site 8
S119
K
G
Y
G
V
V
F
S
N
G
E
R
A
K
Q
Site 9
S131
A
K
Q
L
R
R
F
S
I
A
T
L
R
D
F
Site 10
Y193
V
F
G
D
R
F
D
Y
K
D
K
E
F
L
S
Site 11
S200
Y
K
D
K
E
F
L
S
L
L
R
M
M
L
G
Site 12
S215
I
F
Q
F
T
S
T
S
T
G
Q
L
Y
E
M
Site 13
Y220
S
T
S
T
G
Q
L
Y
E
M
F
S
S
V
M
Site 14
S224
G
Q
L
Y
E
M
F
S
S
V
M
K
H
L
P
Site 15
S225
Q
L
Y
E
M
F
S
S
V
M
K
H
L
P
G
Site 16
T258
K
V
E
H
N
Q
R
T
L
D
P
N
S
P
R
Site 17
S263
Q
R
T
L
D
P
N
S
P
R
D
F
I
D
S
Site 18
S270
S
P
R
D
F
I
D
S
F
L
I
R
M
Q
E
Site 19
Y287
K
N
P
N
T
E
F
Y
L
K
N
L
V
M
T
Site 20
T295
L
K
N
L
V
M
T
T
L
N
L
F
I
G
G
Site 21
S307
I
G
G
T
E
T
V
S
T
T
L
R
Y
G
F
Site 22
T308
G
G
T
E
T
V
S
T
T
L
R
Y
G
F
L
Site 23
Y351
E
D
R
A
K
M
P
Y
M
E
A
V
I
H
E
Site 24
S369
F
G
D
V
I
P
M
S
L
A
R
R
V
K
K
Site 25
T378
A
R
R
V
K
K
D
T
K
F
R
D
F
F
L
Site 26
S403
G
S
V
L
R
D
P
S
F
F
S
N
P
Q
D
Site 27
S426
E
K
G
Q
F
K
K
S
D
A
F
V
P
F
S
Site 28
S464
M
Q
N
F
R
L
K
S
S
Q
S
P
K
D
I
Site 29
S465
Q
N
F
R
L
K
S
S
Q
S
P
K
D
I
D
Site 30
S467
F
R
L
K
S
S
Q
S
P
K
D
I
D
V
S
Site 31
S474
S
P
K
D
I
D
V
S
P
K
H
V
G
F
A
Site 32
T482
P
K
H
V
G
F
A
T
I
P
R
N
Y
T
M
Site 33
Y487
F
A
T
I
P
R
N
Y
T
M
S
F
L
P
R
Site 34
T488
A
T
I
P
R
N
Y
T
M
S
F
L
P
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation