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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PC
Full Name:
Pyruvate carboxylase, mitochondrial
Alias:
PCB; PYC; Pyruvate carboxylase; Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase
Type:
Carbohydrate Metabolism - citrate (TCA) cycle; EC 6.4.1.1; Carbohydrate Metabolism - pyruvate; Ligase
Mass (Da):
129634
Number AA:
1178
UniProt ID:
P11498
International Prot ID:
IPI00299402
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
GO:0005625
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0009374
GO:0030145
PhosphoSite+
KinaseNET
Biological Process:
GO:0006094
GO:0008610
GO:0006006
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
R
L
L
G
I
R
R
T
S
T
A
P
A
A
S
Site 2
S20
L
L
G
I
R
R
T
S
T
A
P
A
A
S
P
Site 3
T21
L
G
I
R
R
T
S
T
A
P
A
A
S
P
N
Site 4
S26
T
S
T
A
P
A
A
S
P
N
V
R
R
L
E
Site 5
Y34
P
N
V
R
R
L
E
Y
K
P
I
K
K
V
M
Site 6
Y67
G
I
R
T
V
A
I
Y
S
E
Q
D
T
G
Q
Site 7
T72
A
I
Y
S
E
Q
D
T
G
Q
M
H
R
Q
K
Site 8
Y84
R
Q
K
A
D
E
A
Y
L
I
G
R
G
L
A
Site 9
Y118
V
D
A
V
H
P
G
Y
G
F
L
S
E
R
A
Site 10
S122
H
P
G
Y
G
F
L
S
E
R
A
D
F
A
Q
Site 11
S142
G
V
R
F
I
G
P
S
P
E
V
V
R
K
M
Site 12
T175
P
G
T
D
A
P
I
T
S
L
H
E
A
H
E
Site 13
S176
G
T
D
A
P
I
T
S
L
H
E
A
H
E
F
Site 14
T186
E
A
H
E
F
S
N
T
Y
G
F
P
I
I
F
Site 15
Y187
A
H
E
F
S
N
T
Y
G
F
P
I
I
F
K
Site 16
S209
R
G
M
R
V
V
H
S
Y
E
E
L
E
E
N
Site 17
Y210
G
M
R
V
V
H
S
Y
E
E
L
E
E
N
Y
Site 18
Y217
Y
E
E
L
E
E
N
Y
T
R
A
Y
S
E
A
Site 19
T218
E
E
L
E
E
N
Y
T
R
A
Y
S
E
A
L
Site 20
Y221
E
E
N
Y
T
R
A
Y
S
E
A
L
A
A
F
Site 21
S222
E
N
Y
T
R
A
Y
S
E
A
L
A
A
F
G
Site 22
Y261
Y
G
N
I
L
H
L
Y
E
R
D
C
S
I
Q
Site 23
T289
H
L
D
P
Q
L
R
T
R
L
T
S
D
S
V
Site 24
T292
P
Q
L
R
T
R
L
T
S
D
S
V
K
L
A
Site 25
S293
Q
L
R
T
R
L
T
S
D
S
V
K
L
A
K
Site 26
S295
R
T
R
L
T
S
D
S
V
K
L
A
K
Q
V
Site 27
Y304
K
L
A
K
Q
V
G
Y
E
N
A
G
T
V
E
Site 28
T309
V
G
Y
E
N
A
G
T
V
E
F
L
V
D
R
Site 29
Y321
V
D
R
H
G
K
H
Y
F
I
E
V
N
S
R
Site 30
T334
S
R
L
Q
V
E
H
T
V
T
E
E
I
T
D
Site 31
T336
L
Q
V
E
H
T
V
T
E
E
I
T
D
V
D
Site 32
T379
C
A
I
Q
C
R
V
T
T
E
D
P
A
R
S
Site 33
T380
A
I
Q
C
R
V
T
T
E
D
P
A
R
S
F
Site 34
S386
T
T
E
D
P
A
R
S
F
Q
P
D
T
G
R
Site 35
T391
A
R
S
F
Q
P
D
T
G
R
I
E
V
F
R
Site 36
S399
G
R
I
E
V
F
R
S
G
E
G
M
G
I
R
Site 37
T438
A
H
G
K
D
H
P
T
A
A
T
K
M
S
R
Site 38
T457
F
R
V
R
G
V
K
T
N
I
A
F
L
Q
N
Site 39
T475
N
Q
Q
F
L
A
G
T
V
D
T
Q
F
I
D
Site 40
Y503
R
A
Q
K
L
L
H
Y
L
G
H
V
M
V
N
Site 41
S521
T
P
I
P
V
K
A
S
P
S
P
T
D
P
V
Site 42
S523
I
P
V
K
A
S
P
S
P
T
D
P
V
V
P
Site 43
T568
P
G
L
L
L
M
D
T
T
F
R
D
A
H
Q
Site 44
T569
G
L
L
L
M
D
T
T
F
R
D
A
H
Q
S
Site 45
S576
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
Site 46
T580
A
H
Q
S
L
L
A
T
R
V
R
T
H
D
L
Site 47
T584
L
L
A
T
R
V
R
T
H
D
L
K
K
I
A
Site 48
Y593
D
L
K
K
I
A
P
Y
V
A
H
N
F
S
K
Site 49
Y620
D
V
A
M
R
F
L
Y
E
C
P
W
R
R
L
Site 50
Y651
R
G
A
N
A
V
G
Y
T
N
Y
P
D
N
V
Site 51
Y654
N
A
V
G
Y
T
N
Y
P
D
N
V
V
F
K
Site 52
S705
G
V
V
E
A
A
I
S
Y
T
G
D
V
A
D
Site 53
S714
T
G
D
V
A
D
P
S
R
T
K
Y
S
L
Q
Site 54
Y718
A
D
P
S
R
T
K
Y
S
L
Q
Y
Y
M
G
Site 55
Y722
R
T
K
Y
S
L
Q
Y
Y
M
G
L
A
E
E
Site 56
Y723
T
K
Y
S
L
Q
Y
Y
M
G
L
A
E
E
L
Site 57
S758
A
C
T
M
L
V
S
S
L
R
D
R
F
P
D
Site 58
T772
D
L
P
L
H
I
H
T
H
D
T
S
G
A
G
Site 59
S802
D
V
A
A
D
S
M
S
G
M
T
S
Q
P
S
Site 60
T805
A
D
S
M
S
G
M
T
S
Q
P
S
M
G
A
Site 61
S806
D
S
M
S
G
M
T
S
Q
P
S
M
G
A
L
Site 62
T824
T
R
G
T
P
L
D
T
E
V
P
M
E
R
V
Site 63
Y834
P
M
E
R
V
F
D
Y
S
E
Y
W
E
G
A
Site 64
Y837
R
V
F
D
Y
S
E
Y
W
E
G
A
R
G
L
Site 65
Y862
K
S
G
N
S
D
V
Y
E
N
E
I
P
G
G
Site 66
Y894
F
K
E
V
K
K
A
Y
V
E
A
N
Q
M
L
Site 67
S939
E
A
Q
A
E
E
L
S
F
P
R
S
V
V
E
Site 68
S943
E
E
L
S
F
P
R
S
V
V
E
F
L
Q
G
Site 69
S965
G
F
P
E
P
F
R
S
K
V
L
K
D
L
P
Site 70
S981
V
E
G
R
P
G
A
S
L
P
P
L
D
L
Q
Site 71
T1003
D
R
H
G
E
E
V
T
P
E
D
V
L
S
A
Site 72
T1024
F
A
H
F
K
D
F
T
A
T
F
G
P
L
D
Site 73
T1026
H
F
K
D
F
T
A
T
F
G
P
L
D
S
L
Site 74
T1057
V
E
L
E
R
G
K
T
L
H
I
K
A
L
A
Site 75
S1086
E
L
N
G
Q
L
R
S
I
L
V
K
D
T
Q
Site 76
T1092
R
S
I
L
V
K
D
T
Q
A
M
K
E
M
H
Site 77
S1151
K
M
E
T
V
V
T
S
P
M
E
G
T
V
R
Site 78
T1156
V
T
S
P
M
E
G
T
V
R
K
V
H
V
T
Site 79
T1163
T
V
R
K
V
H
V
T
K
D
M
T
L
E
G
Site 80
T1167
V
H
V
T
K
D
M
T
L
E
G
D
D
L
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation