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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPTB
Full Name:
Spectrin beta chain, erythrocyte
Alias:
Beta-I spectrin; SPCB; Spectrin, beta, erythrocytic; Spectrin-betaI; Spherocytosis, clinical type I; SPTB1
Type:
Cytoskeletal protein
Mass (Da):
246468
Number AA:
2137
UniProt ID:
P11277
International Prot ID:
IPI00783228
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043234
GO:0008091
Uniprot
OncoNet
Molecular Function:
GO:0051015
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
N
V
G
N
Q
P
P
Y
S
R
I
N
A
R
W
Site 2
S35
D
E
L
D
N
D
N
S
S
A
R
L
F
E
R
Site 3
S36
E
L
D
N
D
N
S
S
A
R
L
F
E
R
S
Site 4
S43
S
A
R
L
F
E
R
S
R
I
K
A
L
A
D
Site 5
T59
R
E
V
V
Q
K
K
T
F
T
K
W
V
N
S
Site 6
T61
V
V
Q
K
K
T
F
T
K
W
V
N
S
H
L
Site 7
S72
N
S
H
L
A
R
V
S
C
R
I
T
D
L
Y
Site 8
T76
A
R
V
S
C
R
I
T
D
L
Y
K
D
L
R
Site 9
Y79
S
C
R
I
T
D
L
Y
K
D
L
R
D
G
R
Site 10
T152
L
V
L
G
L
I
W
T
I
I
L
R
F
Q
I
Site 11
T172
Q
T
Q
E
G
R
E
T
R
S
A
K
D
A
L
Site 12
Y190
C
Q
M
K
T
A
G
Y
P
H
V
N
V
T
N
Site 13
S201
N
V
T
N
F
T
S
S
W
K
D
G
L
A
F
Site 14
S228
D
F
D
K
L
K
D
S
N
A
R
H
N
L
E
Site 15
T258
L
D
P
E
D
V
F
T
E
N
P
D
E
K
S
Site 16
Y307
T
E
K
M
I
E
K
Y
S
G
L
A
S
D
L
Site 17
S312
E
K
Y
S
G
L
A
S
D
L
L
T
W
I
E
Site 18
T316
G
L
A
S
D
L
L
T
W
I
E
Q
T
I
T
Site 19
T323
T
W
I
E
Q
T
I
T
V
L
N
S
R
K
F
Site 20
S333
N
S
R
K
F
A
N
S
L
T
G
V
Q
Q
Q
Site 21
T346
Q
Q
L
Q
A
F
S
T
Y
R
T
V
E
K
P
Site 22
T349
Q
A
F
S
T
Y
R
T
V
E
K
P
P
K
F
Site 23
S371
V
L
L
F
T
I
Q
S
R
M
R
A
N
N
Q
Site 24
Y381
R
A
N
N
Q
K
V
Y
T
P
H
D
G
K
L
Site 25
T382
A
N
N
Q
K
V
Y
T
P
H
D
G
K
L
V
Site 26
S390
P
H
D
G
K
L
V
S
D
I
N
R
A
W
E
Site 27
S398
D
I
N
R
A
W
E
S
L
E
E
A
E
Y
R
Site 28
Y404
E
S
L
E
E
A
E
Y
R
R
E
L
A
L
R
Site 29
T436
R
K
A
A
M
R
E
T
W
L
S
E
N
Q
R
Site 30
S439
A
M
R
E
T
W
L
S
E
N
Q
R
L
V
A
Site 31
T469
K
K
H
E
A
I
E
T
D
T
A
A
Y
E
E
Site 32
Y474
I
E
T
D
T
A
A
Y
E
E
R
V
R
A
L
Site 33
Y493
Q
E
L
E
K
E
N
Y
H
D
Q
K
R
I
T
Site 34
T500
Y
H
D
Q
K
R
I
T
A
R
K
D
N
I
L
Site 35
S511
D
N
I
L
R
L
W
S
Y
L
Q
E
L
L
Q
Site 36
Y512
N
I
L
R
L
W
S
Y
L
Q
E
L
L
Q
S
Site 37
S519
Y
L
Q
E
L
L
Q
S
R
R
Q
R
L
E
T
Site 38
T526
S
R
R
Q
R
L
E
T
T
L
A
L
Q
K
L
Site 39
S553
E
I
K
A
H
L
L
S
A
E
F
G
K
H
L
Site 40
Y600
K
F
T
E
G
K
G
Y
Q
P
C
D
P
Q
V
Site 41
S636
R
K
A
Q
L
E
Q
S
K
R
L
W
K
F
F
Site 42
Y660
I
K
E
K
E
Q
I
Y
S
S
L
D
Y
G
K
Site 43
S661
K
E
K
E
Q
I
Y
S
S
L
D
Y
G
K
D
Site 44
S662
E
K
E
Q
I
Y
S
S
L
D
Y
G
K
D
L
Site 45
Y665
Q
I
Y
S
S
L
D
Y
G
K
D
L
T
S
V
Site 46
S671
D
Y
G
K
D
L
T
S
V
L
I
L
Q
R
K
Site 47
S722
E
A
R
I
K
E
V
S
A
Q
W
D
Q
L
K
Site 48
S767
Q
D
A
H
R
L
L
S
G
E
D
V
G
Q
D
Site 49
S795
F
L
E
E
L
E
E
S
R
G
V
M
E
H
L
Site 50
S816
F
P
E
E
F
R
D
S
P
D
V
T
H
R
L
Site 51
T820
F
R
D
S
P
D
V
T
H
R
L
Q
A
L
R
Site 52
Y851
L
Q
E
A
L
D
L
Y
T
V
F
G
E
T
D
Site 53
T852
Q
E
A
L
D
L
Y
T
V
F
G
E
T
D
A
Site 54
T879
A
E
M
E
M
P
D
T
L
E
D
L
E
V
V
Site 55
S913
G
V
N
L
A
A
N
S
L
V
E
S
G
H
P
Site 56
S917
A
A
N
S
L
V
E
S
G
H
P
R
S
R
E
Site 57
S922
V
E
S
G
H
P
R
S
R
E
V
K
Q
Y
Q
Site 58
Y928
R
S
R
E
V
K
Q
Y
Q
D
H
L
N
T
R
Site 59
S944
Q
A
F
Q
T
L
V
S
E
R
R
E
A
V
D
Site 60
S952
E
R
R
E
A
V
D
S
A
L
R
V
H
N
Y
Site 61
Y959
S
A
L
R
V
H
N
Y
C
V
D
C
E
E
T
Site 62
T971
E
E
T
S
K
W
I
T
D
K
T
K
V
V
E
Site 63
T974
S
K
W
I
T
D
K
T
K
V
V
E
S
T
K
Site 64
S979
D
K
T
K
V
V
E
S
T
K
D
L
G
R
D
Site 65
S998
I
A
I
Q
R
K
L
S
G
L
E
R
D
V
A
Site 66
S1018
V
D
A
L
E
R
E
S
Q
Q
L
M
D
S
H
Site 67
S1024
E
S
Q
Q
L
M
D
S
H
P
E
Q
K
E
D
Site 68
S1049
L
W
Q
G
L
Q
Q
S
L
Q
G
Q
E
D
L
Site 69
S1078
D
D
F
Q
A
W
L
S
I
T
Q
K
A
V
A
Site 70
S1092
A
S
E
D
M
P
E
S
L
P
E
A
E
Q
L
Site 71
S1116
E
I
D
G
H
Q
D
S
Y
Q
R
V
K
E
S
Site 72
Y1117
I
D
G
H
Q
D
S
Y
Q
R
V
K
E
S
G
Site 73
Y1136
Q
G
Q
T
D
P
E
Y
L
L
L
G
Q
R
L
Site 74
T1148
Q
R
L
E
G
L
D
T
G
W
N
A
L
G
R
Site 75
T1163
M
W
E
S
R
S
H
T
L
A
Q
C
L
G
F
Site 76
S1185
K
Q
A
E
A
I
L
S
N
Q
E
Y
T
L
A
Site 77
Y1189
A
I
L
S
N
Q
E
Y
T
L
A
H
L
E
P
Site 78
S1199
A
H
L
E
P
P
D
S
L
E
A
A
E
A
G
Site 79
S1216
K
F
E
D
F
L
G
S
M
E
N
N
R
D
K
Site 80
S1226
N
N
R
D
K
V
L
S
P
V
D
S
G
N
K
Site 81
S1230
K
V
L
S
P
V
D
S
G
N
K
L
V
A
E
Site 82
Y1241
L
V
A
E
G
N
L
Y
S
D
K
I
K
E
K
Site 83
T1296
W
I
N
D
K
L
L
T
S
Q
D
V
S
Y
D
Site 84
S1297
I
N
D
K
L
L
T
S
Q
D
V
S
Y
D
E
Site 85
S1301
L
L
T
S
Q
D
V
S
Y
D
E
A
R
N
L
Site 86
Y1302
L
T
S
Q
D
V
S
Y
D
E
A
R
N
L
H
Site 87
S1324
A
F
V
A
E
L
A
S
H
E
G
W
L
E
N
Site 88
S1351
P
Q
F
T
A
L
V
S
Q
K
L
E
A
L
H
Site 89
T1367
L
W
D
E
L
Q
A
T
T
K
E
K
T
Q
H
Site 90
T1372
Q
A
T
T
K
E
K
T
Q
H
L
S
A
A
R
Site 91
S1376
K
E
K
T
Q
H
L
S
A
A
R
S
S
D
L
Site 92
S1380
Q
H
L
S
A
A
R
S
S
D
L
R
L
Q
T
Site 93
S1381
H
L
S
A
A
R
S
S
D
L
R
L
Q
T
H
Site 94
T1387
S
S
D
L
R
L
Q
T
H
A
D
L
N
K
W
Site 95
S1404
A
M
E
D
Q
L
R
S
D
D
P
G
K
D
L
Site 96
T1412
D
D
P
G
K
D
L
T
S
V
N
R
M
L
A
Site 97
S1413
D
P
G
K
D
L
T
S
V
N
R
M
L
A
K
Site 98
S1444
E
L
F
A
Q
V
P
S
M
G
E
E
G
G
D
Site 99
S1455
E
G
G
D
A
D
L
S
I
E
K
R
F
L
D
Site 100
S1476
R
R
K
K
Q
L
E
S
S
R
A
K
L
Q
I
Site 101
T1491
S
R
D
L
E
D
E
T
L
W
V
E
E
R
L
Site 102
S1503
E
R
L
P
L
A
Q
S
A
D
Y
G
T
N
L
Site 103
Y1506
P
L
A
Q
S
A
D
Y
G
T
N
L
Q
T
V
Site 104
T1512
D
Y
G
T
N
L
Q
T
V
Q
L
F
M
K
K
Site 105
T1531
Q
N
E
I
L
G
H
T
P
R
V
E
D
V
L
Site 106
S1564
E
R
L
G
H
L
Q
S
S
W
D
R
L
R
E
Site 107
S1565
R
L
G
H
L
Q
S
S
W
D
R
L
R
E
A
Site 108
Y1589
D
A
N
E
A
Q
Q
Y
Y
L
D
A
D
E
A
Site 109
Y1590
A
N
E
A
Q
Q
Y
Y
L
D
A
D
E
A
E
Site 110
Y1606
W
I
G
E
Q
E
L
Y
V
I
S
D
E
I
P
Site 111
Y1636
Q
Q
R
A
V
E
D
Y
G
R
N
I
K
Q
L
Site 112
S1645
R
N
I
K
Q
L
A
S
R
A
Q
G
L
L
S
Site 113
S1652
S
R
A
Q
G
L
L
S
A
G
H
P
E
G
E
Site 114
Y1672
Q
G
Q
V
D
K
H
Y
A
G
L
K
D
V
A
Site 115
Y1690
K
R
K
L
E
N
M
Y
H
L
F
Q
L
K
R
Site 116
T1699
L
F
Q
L
K
R
E
T
D
D
L
E
Q
W
I
Site 117
S1707
D
D
L
E
Q
W
I
S
E
K
E
L
V
A
S
Site 118
S1714
S
E
K
E
L
V
A
S
S
P
E
M
G
Q
D
Site 119
S1715
E
K
E
L
V
A
S
S
P
E
M
G
Q
D
F
Site 120
T1726
G
Q
D
F
D
H
V
T
L
L
R
D
K
F
R
Site 121
T1739
F
R
D
F
A
R
E
T
G
A
I
G
Q
E
R
Site 122
T1767
A
G
H
S
E
A
A
T
I
A
E
W
K
D
G
Site 123
Y1797
M
Q
L
L
A
A
S
Y
D
L
H
R
Y
F
Y
Site 124
Y1802
A
S
Y
D
L
H
R
Y
F
Y
T
G
A
E
I
Site 125
Y1804
Y
D
L
H
R
Y
F
Y
T
G
A
E
I
L
G
Site 126
S1829
E
D
V
G
L
D
A
S
T
A
E
S
F
H
R
Site 127
T1830
D
V
G
L
D
A
S
T
A
E
S
F
H
R
V
Site 128
S1833
L
D
A
S
T
A
E
S
F
H
R
V
H
T
A
Site 129
T1839
E
S
F
H
R
V
H
T
A
F
E
R
E
L
H
Site 130
T1864
D
V
A
T
R
L
Q
T
A
Y
A
G
E
K
A
Site 131
Y1866
A
T
R
L
Q
T
A
Y
A
G
E
K
A
E
A
Site 132
S1882
Q
N
K
E
Q
E
V
S
A
A
W
Q
A
L
L
Site 133
T1897
D
A
C
A
G
R
R
T
Q
L
V
D
T
A
D
Site 134
T1902
R
R
T
Q
L
V
D
T
A
D
K
F
R
F
F
Site 135
S1910
A
D
K
F
R
F
F
S
M
A
R
D
L
L
S
Site 136
S1917
S
M
A
R
D
L
L
S
W
M
E
S
I
I
R
Site 137
S1921
D
L
L
S
W
M
E
S
I
I
R
Q
I
E
T
Site 138
S1936
Q
E
R
P
R
D
V
S
S
V
E
L
L
M
K
Site 139
S1937
E
R
P
R
D
V
S
S
V
E
L
L
M
K
Y
Site 140
Y1944
S
V
E
L
L
M
K
Y
H
Q
G
I
N
A
E
Site 141
S1956
N
A
E
I
E
T
R
S
K
N
F
S
A
C
L
Site 142
S1960
E
T
R
S
K
N
F
S
A
C
L
E
L
G
E
Site 143
S1968
A
C
L
E
L
G
E
S
L
L
Q
R
Q
H
Q
Site 144
S1977
L
Q
R
Q
H
Q
A
S
E
E
I
R
E
K
L
Site 145
S1989
E
K
L
Q
Q
V
M
S
R
R
K
E
M
N
E
Site 146
S2019
C
Q
F
S
R
D
A
S
V
A
E
A
W
L
I
Site 147
S2043
D
F
G
H
T
V
D
S
V
E
K
L
I
K
R
Site 148
S2060
A
F
E
K
S
T
A
S
W
A
E
R
F
A
A
Site 149
T2072
F
A
A
L
E
K
P
T
T
L
E
L
K
E
R
Site 150
T2073
A
A
L
E
K
P
T
T
L
E
L
K
E
R
Q
Site 151
T2098
P
Q
E
E
E
G
E
T
A
G
E
A
P
V
S
Site 152
S2105
T
A
G
E
A
P
V
S
H
H
A
A
T
E
R
Site 153
T2110
P
V
S
H
H
A
A
T
E
R
T
S
P
V
S
Site 154
T2113
H
H
A
A
T
E
R
T
S
P
V
S
L
W
S
Site 155
S2114
H
A
A
T
E
R
T
S
P
V
S
L
W
S
R
Site 156
S2117
T
E
R
T
S
P
V
S
L
W
S
R
L
S
S
Site 157
S2120
T
S
P
V
S
L
W
S
R
L
S
S
S
W
E
Site 158
S2123
V
S
L
W
S
R
L
S
S
S
W
E
S
L
Q
Site 159
S2124
S
L
W
S
R
L
S
S
S
W
E
S
L
Q
P
Site 160
S2125
L
W
S
R
L
S
S
S
W
E
S
L
Q
P
E
Site 161
S2128
R
L
S
S
S
W
E
S
L
Q
P
E
P
S
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation