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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PYGM
Full Name:
Glycogen phosphorylase, muscle form
Alias:
EC 2.4.1.1; Glycogen storage disease type V; McArdle syndrome; Myophosphorylase; Phosphorylase, glycogen, muscle; PHS2
Type:
Transferase; EC 2.4.1.1; Endoplasmic reticulum; Carbohydrate Metabolism - starch and sucrose; Phosphorylase
Mass (Da):
97092
Number AA:
842
UniProt ID:
P11217
International Prot ID:
IPI00218130
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008184
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0005977
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
R
P
L
S
D
Q
E
K
R
K
Q
Site 2
S15
Q
E
K
R
K
Q
I
S
V
R
G
L
A
G
V
Site 3
T26
L
A
G
V
E
N
V
T
E
L
K
K
N
F
N
Site 4
T39
F
N
R
H
L
H
F
T
L
V
K
D
R
N
V
Site 5
T48
V
K
D
R
N
V
A
T
P
R
D
Y
Y
F
A
Site 6
Y52
N
V
A
T
P
R
D
Y
Y
F
A
L
A
H
T
Site 7
Y75
W
I
R
T
Q
Q
H
Y
Y
E
K
D
P
K
R
Site 8
Y76
I
R
T
Q
Q
H
Y
Y
E
K
D
P
K
R
I
Site 9
Y84
E
K
D
P
K
R
I
Y
Y
L
S
L
E
F
Y
Site 10
Y85
K
D
P
K
R
I
Y
Y
L
S
L
E
F
Y
M
Site 11
S87
P
K
R
I
Y
Y
L
S
L
E
F
Y
M
G
R
Site 12
Y91
Y
Y
L
S
L
E
F
Y
M
G
R
T
L
Q
N
Site 13
T113
E
N
A
C
D
E
A
T
Y
Q
L
G
L
D
M
Site 14
Y156
A
T
L
G
L
A
A
Y
G
Y
G
I
R
Y
E
Site 15
Y162
A
Y
G
Y
G
I
R
Y
E
F
G
I
F
N
Q
Site 16
Y186
E
A
D
D
W
L
R
Y
G
N
P
W
E
K
A
Site 17
Y204
F
T
L
P
V
H
F
Y
G
H
V
E
H
T
S
Site 18
T229
V
L
A
M
P
Y
D
T
P
V
P
G
Y
R
N
Site 19
S277
R
N
L
A
E
N
I
S
R
V
L
Y
P
N
D
Site 20
Y281
E
N
I
S
R
V
L
Y
P
N
D
N
F
F
E
Site 21
S314
D
I
I
R
R
F
K
S
S
K
F
G
C
R
D
Site 22
S315
I
I
R
R
F
K
S
S
K
F
G
C
R
D
P
Site 23
T325
G
C
R
D
P
V
R
T
N
F
D
A
F
P
D
Site 24
T376
T
V
R
T
C
A
Y
T
N
H
T
V
L
P
E
Site 25
T379
T
C
A
Y
T
N
H
T
V
L
P
E
A
L
E
Site 26
T395
W
P
V
H
L
L
E
T
L
L
P
R
H
L
Q
Site 27
Y405
P
R
H
L
Q
I
I
Y
E
I
N
Q
R
F
L
Site 28
S430
V
D
R
L
R
R
M
S
L
V
E
E
G
A
V
Site 29
S461
N
G
V
A
R
I
H
S
E
I
L
K
K
T
I
Site 30
T467
H
S
E
I
L
K
K
T
I
F
K
D
F
Y
E
Site 31
Y473
K
T
I
F
K
D
F
Y
E
L
E
P
H
K
F
Site 32
T484
P
H
K
F
Q
N
K
T
N
G
I
T
P
R
R
Site 33
T488
Q
N
K
T
N
G
I
T
P
R
R
W
L
V
L
Site 34
S514
R
I
G
E
D
F
I
S
D
L
D
Q
L
R
K
Site 35
S524
D
Q
L
R
K
L
L
S
F
V
D
D
E
A
F
Site 36
Y549
N
K
L
K
F
A
A
Y
L
E
R
E
Y
K
V
Site 37
Y554
A
A
Y
L
E
R
E
Y
K
V
H
I
N
P
N
Site 38
S562
K
V
H
I
N
P
N
S
L
F
D
I
Q
V
K
Site 39
Y574
Q
V
K
R
I
H
E
Y
K
R
Q
L
L
N
C
Site 40
Y588
C
L
H
V
I
T
L
Y
N
R
I
K
R
E
P
Site 41
T603
N
K
F
F
V
P
R
T
V
M
I
G
G
K
A
Site 42
Y614
G
G
K
A
A
P
G
Y
H
M
A
K
M
I
I
Site 43
T625
K
M
I
I
R
L
V
T
A
I
G
D
V
V
N
Site 44
Y649
R
V
I
F
L
E
N
Y
R
V
S
L
A
E
K
Site 45
S668
A
D
L
S
E
Q
I
S
T
A
G
T
E
A
S
Site 46
T672
E
Q
I
S
T
A
G
T
E
A
S
G
T
G
N
Site 47
S675
S
T
A
G
T
E
A
S
G
T
G
N
M
K
F
Site 48
T677
A
G
T
E
A
S
G
T
G
N
M
K
F
M
L
Site 49
Y727
D
K
L
D
Q
R
G
Y
N
A
Q
E
Y
Y
D
Site 50
Y732
R
G
Y
N
A
Q
E
Y
Y
D
R
I
P
E
L
Site 51
Y733
G
Y
N
A
Q
E
Y
Y
D
R
I
P
E
L
R
Site 52
S747
R
Q
V
I
E
Q
L
S
S
G
F
F
S
P
K
Site 53
S748
Q
V
I
E
Q
L
S
S
G
F
F
S
P
K
Q
Site 54
S752
Q
L
S
S
G
F
F
S
P
K
Q
P
D
L
F
Site 55
Y778
R
F
K
V
F
A
D
Y
E
D
Y
I
K
C
Q
Site 56
Y781
V
F
A
D
Y
E
D
Y
I
K
C
Q
E
K
V
Site 57
S789
I
K
C
Q
E
K
V
S
A
L
Y
K
N
P
R
Site 58
Y792
Q
E
K
V
S
A
L
Y
K
N
P
R
E
W
T
Site 59
S809
V
I
R
N
I
A
T
S
G
K
F
S
S
D
R
Site 60
S813
I
A
T
S
G
K
F
S
S
D
R
T
I
A
Q
Site 61
S814
A
T
S
G
K
F
S
S
D
R
T
I
A
Q
Y
Site 62
T817
G
K
F
S
S
D
R
T
I
A
Q
Y
A
R
E
Site 63
Y821
S
D
R
T
I
A
Q
Y
A
R
E
I
W
G
V
Site 64
S831
E
I
W
G
V
E
P
S
R
Q
R
L
P
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation