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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DBT
Full Name:
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
Alias:
2-methylpropanoyl; BCATE2; BCKAD E2; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; EC 2.3.1.168; Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; ODB2
Type:
Enzyme, transferase
Mass (Da):
53487
Number AA:
482
UniProt ID:
P11182
International Prot ID:
IPI00003944
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005947
GO:0042645
Uniprot
OncoNet
Molecular Function:
GO:0008415
GO:0043754
GO:0031405
PhosphoSite+
KinaseNET
Biological Process:
GO:0046949
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
A
V
R
M
L
R
T
W
S
R
N
A
G
K
Site 2
S11
V
R
M
L
R
T
W
S
R
N
A
G
K
L
I
Site 3
Y47
F
G
Y
P
S
F
K
Y
S
H
P
H
H
F
L
Site 4
T56
H
P
H
H
F
L
K
T
T
A
A
L
R
G
Q
Site 5
T57
P
H
H
F
L
K
T
T
A
A
L
R
G
Q
V
Site 6
S70
Q
V
V
Q
F
K
L
S
D
I
G
E
G
I
R
Site 7
T80
G
E
G
I
R
E
V
T
V
K
E
W
Y
V
K
Site 8
Y85
E
V
T
V
K
E
W
Y
V
K
E
G
D
T
V
Site 9
T91
W
Y
V
K
E
G
D
T
V
S
Q
F
D
S
I
Site 10
S93
V
K
E
G
D
T
V
S
Q
F
D
S
I
C
E
Site 11
S97
D
T
V
S
Q
F
D
S
I
C
E
V
Q
S
D
Site 12
S103
D
S
I
C
E
V
Q
S
D
K
A
S
V
T
I
Site 13
S107
E
V
Q
S
D
K
A
S
V
T
I
T
S
R
Y
Site 14
T111
D
K
A
S
V
T
I
T
S
R
Y
D
G
V
I
Site 15
Y114
S
V
T
I
T
S
R
Y
D
G
V
I
K
K
L
Site 16
Y122
D
G
V
I
K
K
L
Y
Y
N
L
D
D
I
A
Site 17
Y130
Y
N
L
D
D
I
A
Y
V
G
K
P
L
V
D
Site 18
T140
K
P
L
V
D
I
E
T
E
A
L
K
D
S
E
Site 19
S146
E
T
E
A
L
K
D
S
E
E
D
V
V
E
T
Site 20
T153
S
E
E
D
V
V
E
T
P
A
V
S
H
D
E
Site 21
S157
V
V
E
T
P
A
V
S
H
D
E
H
T
H
Q
Site 22
T171
Q
E
I
K
G
R
K
T
L
A
T
P
A
V
R
Site 23
T174
K
G
R
K
T
L
A
T
P
A
V
R
R
L
A
Site 24
S189
M
E
N
N
I
K
L
S
E
V
V
G
S
G
K
Site 25
S194
K
L
S
E
V
V
G
S
G
K
D
G
R
I
L
Site 26
Y208
L
K
E
D
I
L
N
Y
L
E
K
Q
T
G
A
Site 27
T236
P
P
K
P
K
D
M
T
V
P
I
L
V
S
K
Site 28
T253
V
F
T
G
K
D
K
T
E
P
I
K
G
F
Q
Site 29
T285
Y
C
D
E
I
D
L
T
E
L
V
K
L
R
E
Site 30
T372
C
S
I
F
D
I
A
T
E
L
N
R
L
Q
K
Site 31
S382
N
R
L
Q
K
L
G
S
V
G
Q
L
S
T
T
Site 32
T389
S
V
G
Q
L
S
T
T
D
L
T
G
G
T
F
Site 33
T392
Q
L
S
T
T
D
L
T
G
G
T
F
T
L
S
Site 34
T395
T
T
D
L
T
G
G
T
F
T
L
S
N
I
G
Site 35
S399
T
G
G
T
F
T
L
S
N
I
G
S
I
G
G
Site 36
S403
F
T
L
S
N
I
G
S
I
G
G
T
F
A
K
Site 37
S447
K
A
Q
I
M
N
V
S
W
S
A
D
H
R
V
Site 38
T459
H
R
V
I
D
G
A
T
M
S
R
F
S
N
L
Site 39
S461
V
I
D
G
A
T
M
S
R
F
S
N
L
W
K
Site 40
S464
G
A
T
M
S
R
F
S
N
L
W
K
S
Y
L
Site 41
S469
R
F
S
N
L
W
K
S
Y
L
E
N
P
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation