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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LIPC
Full Name:
Hepatic triacylglycerol lipase
Alias:
EC 3.1.1.3; Hepatic lipase; HL; HTGL; Lipase C; Lipase, hepatic; LIPH
Type:
Enzyme, cellular metabolism, Lipid Metabolism group, Glycerolipid metabolism family
Mass (Da):
55880
Number AA:
499
UniProt ID:
P11150
International Prot ID:
IPI00003882
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034364
Uniprot
OncoNet
Molecular Function:
GO:0034185
GO:0008201
GO:0030169
PhosphoSite+
KinaseNET
Biological Process:
GO:0042632
GO:0034382
GO:0006633
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
Q
S
S
A
L
G
Q
S
L
K
P
E
P
F
G
Site 2
T44
Q
A
V
E
T
N
K
T
L
H
E
M
K
T
R
Site 3
T71
I
R
I
N
H
P
D
T
L
Q
E
C
G
F
N
Site 4
S109
Q
M
V
A
A
L
K
S
Q
P
A
Q
P
V
N
Site 5
Y130
I
T
L
A
H
D
H
Y
T
I
A
V
R
N
T
Site 6
T131
T
L
A
H
D
H
Y
T
I
A
V
R
N
T
R
Site 7
T137
Y
T
I
A
V
R
N
T
R
L
V
G
K
E
V
Site 8
S154
L
L
R
W
L
E
E
S
V
Q
L
S
R
S
H
Site 9
S158
L
E
E
S
V
Q
L
S
R
S
H
V
H
L
I
Site 10
S160
E
S
V
Q
L
S
R
S
H
V
H
L
I
G
Y
Site 11
S179
H
V
S
G
F
A
G
S
S
I
G
G
T
H
K
Site 12
T184
A
G
S
S
I
G
G
T
H
K
I
G
R
I
T
Site 13
T191
T
H
K
I
G
R
I
T
G
L
D
A
A
G
P
Site 14
S203
A
G
P
L
F
E
G
S
A
P
S
N
R
L
S
Site 15
S206
L
F
E
G
S
A
P
S
N
R
L
S
P
D
D
Site 16
S210
S
A
P
S
N
R
L
S
P
D
D
A
N
F
V
Site 17
T222
N
F
V
D
A
I
H
T
F
T
R
E
H
M
G
Site 18
S231
T
R
E
H
M
G
L
S
V
G
I
K
Q
P
I
Site 19
Y244
P
I
G
H
Y
D
F
Y
P
N
G
G
S
F
Q
Site 20
Y260
G
C
H
F
L
E
L
Y
R
H
I
A
Q
H
G
Site 21
T274
G
F
N
A
I
T
Q
T
I
K
C
S
H
E
R
Site 22
S278
I
T
Q
T
I
K
C
S
H
E
R
S
V
H
L
Site 23
S282
I
K
C
S
H
E
R
S
V
H
L
F
I
D
S
Site 24
T295
D
S
L
L
H
A
G
T
Q
S
M
A
Y
P
C
Site 25
Y300
A
G
T
Q
S
M
A
Y
P
C
G
D
M
N
S
Site 26
Y326
G
R
C
N
T
L
G
Y
H
V
R
Q
E
P
R
Site 27
S334
H
V
R
Q
E
P
R
S
K
S
K
R
L
F
L
Site 28
S336
R
Q
E
P
R
S
K
S
K
R
L
F
L
V
T
Site 29
T343
S
K
R
L
F
L
V
T
R
A
Q
S
P
F
K
Site 30
S347
F
L
V
T
R
A
Q
S
P
F
K
V
Y
H
Y
Site 31
Y354
S
P
F
K
V
Y
H
Y
Q
L
K
I
Q
F
I
Site 32
T366
Q
F
I
N
Q
T
E
T
P
I
Q
T
T
F
T
Site 33
S375
I
Q
T
T
F
T
M
S
L
L
G
T
K
E
K
Site 34
T379
F
T
M
S
L
L
G
T
K
E
K
M
Q
K
I
Site 35
S440
V
Q
T
I
I
P
W
S
T
G
P
R
H
S
G
Site 36
T441
Q
T
I
I
P
W
S
T
G
P
R
H
S
G
L
Site 37
S446
W
S
T
G
P
R
H
S
G
L
V
L
K
T
I
Site 38
T452
H
S
G
L
V
L
K
T
I
R
V
K
A
G
E
Site 39
T465
G
E
T
Q
Q
R
M
T
F
C
S
E
N
T
D
Site 40
S468
Q
Q
R
M
T
F
C
S
E
N
T
D
D
L
L
Site 41
T479
D
D
L
L
L
R
P
T
Q
E
K
I
F
V
K
Site 42
T493
K
C
E
I
K
S
K
T
S
K
R
K
I
R
_
Site 43
S494
C
E
I
K
S
K
T
S
K
R
K
I
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation