KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HSPA8
Full Name:
Heat shock cognate 71 kDa protein
Alias:
Heat shock 70 kDa protein 8; HS7C; HSP73; HSP7C; HSPA10
Type:
Chaperone protein
Mass (Da):
70898
Number AA:
646
UniProt ID:
P11142
International Prot ID:
IPI00003865
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0042470
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042623
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0016044
GO:0006892
Phosida
TranscriptoNet
STRING
Kinexus Products
Heat shock cognate 71 kDa protein pan-specific antibody AB-NN054-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN054-2#Heat shock cognate 71 kDa protein phosphosite-specific antibody AB-NN054-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN054-3#Heat shock cognate 71 kDa protein pan-specific antibody AB-NN054-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN054-4
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
Site 2
Y15
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Site 3
S16
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
Site 4
T38
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
Site 5
S40
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
Site 6
Y41
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
E
Site 7
T47
S
Y
V
A
F
T
D
T
E
R
L
I
G
D
A
Site 8
T66
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
Site 9
S85
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
Site 10
Y107
R
P
K
V
Q
V
E
Y
K
G
E
T
K
S
F
Site 11
T111
Q
V
E
Y
K
G
E
T
K
S
F
Y
P
E
E
Site 12
S113
E
Y
K
G
E
T
K
S
F
Y
P
E
E
V
S
Site 13
Y115
K
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
Site 14
S120
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
Site 15
S121
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
Site 16
T125
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
Site 17
Y134
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
Site 18
T138
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
Site 19
T140
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
Site 20
Y149
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
Site 21
S153
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
Site 22
T158
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
Site 23
T163
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
Site 24
T177
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
Site 25
S208
G
G
G
T
F
D
V
S
I
L
T
I
E
D
G
Site 26
S221
D
G
I
F
E
V
K
S
T
A
G
D
T
H
L
Site 27
S254
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
Site 28
T265
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
Site 29
T273
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
Site 30
S275
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
Site 31
S277
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
Site 32
S281
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
Site 33
S286
Q
A
S
I
E
I
D
S
L
Y
E
G
I
D
F
Site 34
Y288
S
I
E
I
D
S
L
Y
E
G
I
D
F
Y
T
Site 35
Y294
L
Y
E
G
I
D
F
Y
T
S
I
T
R
A
R
Site 36
T295
Y
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
Site 37
S296
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
Site 38
T298
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
Site 39
T313
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
Site 40
S329
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
Site 41
T341
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
Site 42
S362
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
Site 43
S385
A
I
L
S
G
D
K
S
E
N
V
Q
D
L
L
Site 44
T397
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
Site 45
S400
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
Site 46
T411
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
Site 47
T418
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Site 48
T419
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
Site 49
T427
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Site 50
T429
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
Site 51
T430
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
Site 52
Y431
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
Site 53
S432
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
Site 54
T450
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
Site 55
T477
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
Site 56
S494
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
Site 57
T502
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
Site 58
S511
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
Site 59
Y525
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
Site 60
S537
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Site 61
S538
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
Site 62
S541
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
Site 63
S544
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
Site 64
Y545
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
Site 65
Y611
N
P
I
I
T
K
L
Y
Q
S
A
G
G
M
P
Site 66
S613
I
I
T
K
L
Y
Q
S
A
G
G
M
P
G
G
Site 67
S633
P
G
G
G
A
P
P
S
G
G
A
S
S
G
P
Site 68
S637
A
P
P
S
G
G
A
S
S
G
P
T
I
E
E
Site 69
S638
P
P
S
G
G
A
S
S
G
P
T
I
E
E
V
Site 70
T641
G
G
A
S
S
G
P
T
I
E
E
V
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation