KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LAMC1
Full Name:
Laminin subunit gamma-1
Alias:
LAMB2; Laminin B2; Laminin B2 chain; Laminin, gamma 1
Type:
Extracellular adhesion protein
Mass (Da):
177603
Number AA:
1609
UniProt ID:
P11047
International Prot ID:
IPI00298281
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005578
GO:0005604
Uniprot
OncoNet
Molecular Function:
GO:0005198
GO:0005201
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006461
GO:0006928
GO:0007044
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T41
Q
A
A
M
D
E
C
T
D
E
G
G
R
P
Q
Site 2
T71
V
A
T
N
T
C
G
T
P
P
E
E
Y
C
V
Site 3
Y76
C
G
T
P
P
E
E
Y
C
V
Q
T
G
V
T
Site 4
Y109
G
A
A
F
L
T
D
Y
N
N
Q
A
D
T
T
Site 5
Y147
G
K
A
F
D
I
T
Y
V
R
L
K
F
H
T
Site 6
T154
Y
V
R
L
K
F
H
T
S
R
P
E
S
F
A
Site 7
S155
V
R
L
K
F
H
T
S
R
P
E
S
F
A
I
Site 8
S159
F
H
T
S
R
P
E
S
F
A
I
Y
K
R
T
Site 9
Y163
R
P
E
S
F
A
I
Y
K
R
T
R
E
D
G
Site 10
T166
S
F
A
I
Y
K
R
T
R
E
D
G
P
W
I
Site 11
Y175
E
D
G
P
W
I
P
Y
Q
Y
Y
S
G
S
C
Site 12
Y177
G
P
W
I
P
Y
Q
Y
Y
S
G
S
C
E
N
Site 13
S179
W
I
P
Y
Q
Y
Y
S
G
S
C
E
N
T
Y
Site 14
S181
P
Y
Q
Y
Y
S
G
S
C
E
N
T
Y
S
K
Site 15
T185
Y
S
G
S
C
E
N
T
Y
S
K
A
N
R
G
Site 16
Y186
S
G
S
C
E
N
T
Y
S
K
A
N
R
G
F
Site 17
S187
G
S
C
E
N
T
Y
S
K
A
N
R
G
F
I
Site 18
T196
A
N
R
G
F
I
R
T
G
G
D
E
Q
Q
A
Site 19
T206
D
E
Q
Q
A
L
C
T
D
E
F
S
D
I
S
Site 20
S210
A
L
C
T
D
E
F
S
D
F
S
P
L
T
G
Site 21
S213
T
D
E
F
S
D
I
S
P
L
T
G
G
N
V
Site 22
T216
F
S
D
F
S
P
L
T
G
G
N
V
A
F
S
Site 23
S223
T
G
G
N
V
A
F
S
T
L
E
G
R
P
S
Site 24
T224
G
G
N
V
A
F
S
T
L
E
G
R
P
S
A
Site 25
S230
S
T
L
E
G
R
P
S
A
Y
N
F
D
N
S
Site 26
S237
S
A
Y
N
F
D
N
S
P
V
L
Q
E
W
V
Site 27
T252
T
A
T
D
I
R
V
T
L
N
R
L
N
T
F
Site 28
T258
V
T
L
N
R
L
N
T
F
G
D
E
V
F
N
Site 29
S272
N
D
P
K
V
L
K
S
Y
Y
Y
A
I
S
D
Site 30
Y273
D
P
K
V
L
K
S
Y
Y
Y
A
I
S
D
F
Site 31
Y274
P
K
V
L
K
S
Y
Y
Y
A
I
S
D
F
A
Site 32
S278
K
S
Y
Y
Y
A
I
S
D
F
A
V
G
G
R
Site 33
T332
D
R
P
W
R
R
A
T
A
E
S
A
S
E
C
Site 34
S335
W
R
R
A
T
A
E
S
A
S
E
C
L
P
C
Site 35
Y352
N
G
R
S
Q
E
C
Y
F
D
P
E
L
Y
R
Site 36
Y358
C
Y
F
D
P
E
L
Y
R
S
T
G
H
G
G
Site 37
T361
D
P
E
L
Y
R
S
T
G
H
G
G
H
C
T
Site 38
S405
C
H
C
S
P
V
G
S
L
S
T
Q
C
D
S
Site 39
S407
C
S
P
V
G
S
L
S
T
Q
C
D
S
Y
G
Site 40
T408
S
P
V
G
S
L
S
T
Q
C
D
S
Y
G
R
Site 41
S412
S
L
S
T
Q
C
D
S
Y
G
R
C
S
C
K
Site 42
Y413
L
S
T
Q
C
D
S
Y
G
R
C
S
C
K
P
Site 43
S436
R
C
Q
P
G
F
H
S
L
T
E
A
G
C
R
Site 44
T438
Q
P
G
F
H
S
L
T
E
A
G
C
R
P
C
Site 45
S446
E
A
G
C
R
P
C
S
C
D
P
S
G
S
I
Site 46
S450
R
P
C
S
C
D
P
S
G
S
I
D
E
C
N
Site 47
S452
C
S
C
D
P
S
G
S
I
D
E
C
N
I
E
Site 48
S486
P
G
F
F
N
L
E
S
S
N
P
R
G
C
T
Site 49
S487
G
F
F
N
L
E
S
S
N
P
R
G
C
T
P
Site 50
T518
S
V
Y
S
I
S
S
T
F
Q
I
D
E
D
G
Site 51
S534
R
A
E
Q
R
D
G
S
E
A
S
L
E
W
S
Site 52
S537
Q
R
D
G
S
E
A
S
L
E
W
S
S
E
R
Site 53
S541
S
E
A
S
L
E
W
S
S
E
R
Q
D
I
A
Site 54
S542
E
A
S
L
E
W
S
S
E
R
Q
D
I
A
V
Site 55
S551
R
Q
D
I
A
V
I
S
D
S
Y
F
P
R
Y
Site 56
Y558
S
D
S
Y
F
P
R
Y
F
I
A
P
A
K
F
Site 57
Y573
L
G
K
Q
V
L
S
Y
G
Q
N
L
S
F
S
Site 58
S578
L
S
Y
G
Q
N
L
S
F
S
F
R
V
D
R
Site 59
S580
Y
G
Q
N
L
S
F
S
F
R
V
D
R
R
D
Site 60
T588
F
R
V
D
R
R
D
T
R
L
S
A
E
D
L
Site 61
S591
D
R
R
D
T
R
L
S
A
E
D
L
V
L
E
Site 62
Y615
L
I
A
Q
G
N
S
Y
P
S
E
T
T
V
K
Site 63
Y623
P
S
E
T
T
V
K
Y
V
F
R
L
H
E
A
Site 64
T631
V
F
R
L
H
E
A
T
D
Y
P
W
R
P
A
Site 65
Y633
R
L
H
E
A
T
D
Y
P
W
R
P
A
L
T
Site 66
T640
Y
P
W
R
P
A
L
T
P
F
E
F
Q
K
L
Site 67
S653
K
L
L
N
N
L
T
S
I
K
I
R
G
T
Y
Site 68
T659
T
S
I
K
I
R
G
T
Y
S
E
R
S
A
G
Site 69
Y660
S
I
K
I
R
G
T
Y
S
E
R
S
A
G
Y
Site 70
S661
I
K
I
R
G
T
Y
S
E
R
S
A
G
Y
L
Site 71
S664
R
G
T
Y
S
E
R
S
A
G
Y
L
D
D
V
Site 72
Y667
Y
S
E
R
S
A
G
Y
L
D
D
V
T
L
A
Site 73
T672
A
G
Y
L
D
D
V
T
L
A
S
A
R
P
G
Site 74
S675
L
D
D
V
T
L
A
S
A
R
P
G
P
G
V
Site 75
Y708
C
E
M
C
L
S
G
Y
R
R
E
T
P
N
L
Site 76
T712
L
S
G
Y
R
R
E
T
P
N
L
G
P
Y
S
Site 77
T732
A
C
N
G
H
S
E
T
C
D
P
E
T
G
V
Site 78
T737
S
E
T
C
D
P
E
T
G
V
C
N
C
R
D
Site 79
Y758
C
E
K
C
S
D
G
Y
Y
G
D
S
T
A
G
Site 80
Y759
E
K
C
S
D
G
Y
Y
G
D
S
T
A
G
T
Site 81
S762
S
D
G
Y
Y
G
D
S
T
A
G
T
S
S
D
Site 82
T763
D
G
Y
Y
G
D
S
T
A
G
T
S
S
D
C
Site 83
T766
Y
G
D
S
T
A
G
T
S
S
D
C
Q
P
C
Site 84
S768
D
S
T
A
G
T
S
S
D
C
Q
P
C
P
C
Site 85
T793
K
T
K
E
V
V
C
T
N
C
P
T
G
T
T
Site 86
Y811
C
E
L
C
D
D
G
Y
F
G
D
P
L
G
R
Site 87
Y889
K
A
C
N
C
N
L
Y
G
T
M
K
Q
Q
S
Site 88
S896
Y
G
T
M
K
Q
Q
S
S
C
N
P
V
T
G
Site 89
Y924
G
A
C
D
P
G
F
Y
N
L
Q
S
G
Q
G
Site 90
S990
C
D
C
H
P
E
G
S
L
S
L
Q
C
K
D
Site 91
S992
C
H
P
E
G
S
L
S
L
Q
C
K
D
D
G
Site 92
T1109
R
L
Q
R
V
N
N
T
L
S
S
Q
I
S
R
Site 93
S1111
Q
R
V
N
N
T
L
S
S
Q
I
S
R
L
Q
Site 94
S1112
R
V
N
N
T
L
S
S
Q
I
S
R
L
Q
N
Site 95
S1115
N
T
L
S
S
Q
I
S
R
L
Q
N
I
R
N
Site 96
T1123
R
L
Q
N
I
R
N
T
I
E
E
T
G
N
L
Site 97
S1163
K
V
A
A
A
N
V
S
V
T
Q
P
E
S
T
Site 98
T1165
A
A
A
N
V
S
V
T
Q
P
E
S
T
G
D
Site 99
S1169
V
S
V
T
Q
P
E
S
T
G
D
P
N
N
M
Site 100
T1177
T
G
D
P
N
N
M
T
L
L
A
E
E
A
R
Site 101
T1203
D
I
V
R
V
A
K
T
A
N
D
T
S
T
E
Site 102
T1209
K
T
A
N
D
T
S
T
E
A
Y
N
L
L
L
Site 103
Y1236
I
E
E
L
N
R
K
Y
E
Q
A
K
N
I
S
Site 104
S1275
Y
A
S
V
A
Q
L
S
P
L
D
S
E
T
L
Site 105
S1279
A
Q
L
S
P
L
D
S
E
T
L
E
N
E
A
Site 106
T1281
L
S
P
L
D
S
E
T
L
E
N
E
A
N
N
Site 107
Y1307
I
D
Q
K
L
K
D
Y
E
D
L
R
E
D
M
Site 108
T1330
N
L
L
E
K
G
K
T
E
Q
Q
T
A
D
Q
Site 109
T1359
A
A
K
K
G
R
D
T
L
Q
E
A
N
D
I
Site 110
T1382
R
R
V
N
D
N
K
T
A
A
E
E
A
L
R
Site 111
S1434
H
E
A
E
R
I
A
S
A
V
Q
K
N
A
T
Site 112
T1450
T
K
A
E
A
E
R
T
F
A
E
V
T
D
L
Site 113
S1493
M
M
M
A
G
M
A
S
Q
A
A
Q
E
A
E
Site 114
S1509
N
A
R
K
A
K
N
S
V
T
S
L
L
S
I
Site 115
S1512
K
A
K
N
S
V
T
S
L
L
S
I
I
N
D
Site 116
T1529
E
Q
L
G
Q
L
D
T
V
D
L
N
K
L
N
Site 117
T1541
K
L
N
E
I
E
G
T
L
N
K
A
K
D
E
Site 118
S1552
A
K
D
E
M
K
V
S
D
L
D
R
K
V
S
Site 119
S1559
S
D
L
D
R
K
V
S
D
L
E
N
E
A
K
Site 120
Y1575
Q
E
A
A
I
M
D
Y
N
R
D
I
E
E
I
Site 121
T1595
N
L
E
D
I
R
K
T
L
P
S
G
C
F
N
Site 122
S1598
D
I
R
K
T
L
P
S
G
C
F
N
T
P
S
Site 123
T1603
L
P
S
G
C
F
N
T
P
S
I
E
K
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation