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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HAPLN1
Full Name:
Hyaluronan and proteoglycan link protein 1
Alias:
Cartilage link protein; CRTL1; HPLN1; hyaluronan and proteoglycan link protein 1
Type:
Extracellular matrix
Mass (Da):
40166
Number AA:
354
UniProt ID:
P10915
International Prot ID:
IPI00023601
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005540
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
A
D
H
L
S
D
N
Y
T
L
D
H
D
R
A
Site 2
T23
D
H
L
S
D
N
Y
T
L
D
H
D
R
A
I
Site 3
S51
A
E
Q
A
K
V
F
S
H
R
G
G
N
V
T
Site 4
T58
S
H
R
G
G
N
V
T
L
P
C
K
F
Y
R
Site 5
Y64
V
T
L
P
C
K
F
Y
R
D
P
T
A
F
G
Site 6
T68
C
K
F
Y
R
D
P
T
A
F
G
S
G
I
H
Site 7
S86
I
K
W
T
K
L
T
S
D
Y
L
K
E
V
D
Site 8
Y88
W
T
K
L
T
S
D
Y
L
K
E
V
D
V
F
Site 9
Y100
D
V
F
V
S
M
G
Y
H
K
K
T
Y
G
G
Site 10
T104
S
M
G
Y
H
K
K
T
Y
G
G
Y
Q
G
R
Site 11
Y105
M
G
Y
H
K
K
T
Y
G
G
Y
Q
G
R
V
Site 12
Y108
H
K
K
T
Y
G
G
Y
Q
G
R
V
F
L
K
Site 13
S118
R
V
F
L
K
G
G
S
D
S
D
A
S
L
V
Site 14
T130
S
L
V
I
T
D
L
T
L
E
D
Y
G
R
Y
Site 15
Y134
T
D
L
T
L
E
D
Y
G
R
Y
K
C
E
V
Site 16
S190
D
Q
D
A
V
I
A
S
F
D
Q
L
Y
D
A
Site 17
Y195
I
A
S
F
D
Q
L
Y
D
A
W
R
G
G
L
Site 18
S214
A
G
W
L
S
D
G
S
V
Q
Y
P
I
T
K
Site 19
Y217
L
S
D
G
S
V
Q
Y
P
I
T
K
P
R
E
Site 20
T220
G
S
V
Q
Y
P
I
T
K
P
R
E
P
C
G
Site 21
T231
E
P
C
G
G
Q
N
T
V
P
G
V
R
N
Y
Site 22
Y238
T
V
P
G
V
R
N
Y
G
F
W
D
K
D
K
Site 23
Y262
S
N
F
N
G
R
F
Y
Y
L
I
H
P
T
K
Site 24
Y263
N
F
N
G
R
F
Y
Y
L
I
H
P
T
K
L
Site 25
Y301
A
A
W
K
I
L
G
Y
D
R
C
D
A
G
W
Site 26
S313
A
G
W
L
A
D
G
S
V
R
Y
P
I
S
R
Site 27
Y316
L
A
D
G
S
V
R
Y
P
I
S
R
P
R
R
Site 28
S319
G
S
V
R
Y
P
I
S
R
P
R
R
R
C
S
Site 29
S326
S
R
P
R
R
R
C
S
P
T
E
A
A
V
R
Site 30
T328
P
R
R
R
C
S
P
T
E
A
A
V
R
F
V
Site 31
Y345
P
D
K
K
H
K
L
Y
G
V
Y
C
F
R
A
Site 32
Y348
K
H
K
L
Y
G
V
Y
C
F
R
A
Y
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation