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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCF2
Full Name:
Proto-oncogene DBL
Alias:
Proto-oncogene MCF-2
Type:
Mass (Da):
107673
Number AA:
925
UniProt ID:
P10911
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
R
F
R
R
N
A
A
S
F
P
G
N
L
H
L
Site 2
T39
P
T
S
F
L
Q
R
T
F
T
D
I
G
F
W
Site 3
S48
T
D
I
G
F
W
F
S
Q
E
D
F
M
L
K
Site 4
T69
S
S
V
S
D
L
L
T
Y
I
D
D
K
Q
L
Site 5
Y70
S
V
S
D
L
L
T
Y
I
D
D
K
Q
L
T
Site 6
T77
Y
I
D
D
K
Q
L
T
P
E
L
G
G
T
L
Site 7
T83
L
T
P
E
L
G
G
T
L
Q
Y
C
H
S
E
Site 8
Y86
E
L
G
G
T
L
Q
Y
C
H
S
E
W
I
I
Site 9
S114
E
M
A
Q
M
L
Q
S
F
G
T
E
L
A
E
Site 10
T122
F
G
T
E
L
A
E
T
E
L
P
D
D
I
P
Site 11
T150
H
L
L
K
N
D
I
T
A
V
T
K
E
G
K
Site 12
T168
T
N
L
E
V
P
D
T
E
G
A
V
S
S
R
Site 13
S173
P
D
T
E
G
A
V
S
S
R
L
E
C
H
R
Site 14
T188
Q
I
S
G
D
W
Q
T
I
N
K
L
L
T
Q
Site 15
Y217
H
Q
L
K
M
E
Q
Y
L
Q
L
W
K
F
E
Site 16
S268
L
E
N
L
D
E
N
S
Q
E
L
L
S
K
A
Site 17
S273
E
N
S
Q
E
L
L
S
K
A
Q
F
V
I
L
Site 18
Y305
Q
R
C
N
E
L
R
Y
L
S
D
I
L
V
N
Site 19
S322
K
A
K
R
I
Q
L
S
R
T
F
K
M
H
K
Site 20
T324
K
R
I
Q
L
S
R
T
F
K
M
H
K
L
L
Site 21
Y379
M
A
L
P
F
I
N
Y
E
P
E
T
L
Q
Y
Site 22
Y386
Y
E
P
E
T
L
Q
Y
E
F
D
V
I
L
S
Site 23
S412
L
K
L
E
N
I
R
S
I
F
E
N
Q
Q
A
Site 24
T444
P
T
P
E
N
L
V
T
S
G
T
P
F
F
S
Site 25
S445
T
P
E
N
L
V
T
S
G
T
P
F
F
S
S
Site 26
T447
E
N
L
V
T
S
G
T
P
F
F
S
S
K
Q
Site 27
S452
S
G
T
P
F
F
S
S
K
Q
G
K
K
T
W
Site 28
T458
S
S
K
Q
G
K
K
T
W
R
Q
N
Q
S
N
Site 29
S479
P
D
C
Q
E
K
R
S
S
G
P
S
S
S
L
Site 30
S480
D
C
Q
E
K
R
S
S
G
P
S
S
S
L
D
Site 31
S483
E
K
R
S
S
G
P
S
S
S
L
D
N
G
N
Site 32
S484
K
R
S
S
G
P
S
S
S
L
D
N
G
N
S
Site 33
S485
R
S
S
G
P
S
S
S
L
D
N
G
N
S
L
Site 34
S491
S
S
L
D
N
G
N
S
L
D
V
L
K
N
H
Site 35
T506
V
L
N
E
L
I
Q
T
E
R
V
Y
V
R
E
Site 36
Y553
F
G
N
M
A
E
I
Y
E
F
H
N
D
I
F
Site 37
S563
H
N
D
I
F
L
S
S
L
E
N
C
A
H
A
Site 38
Y588
R
K
D
D
F
Q
M
Y
A
K
Y
C
Q
N
K
Site 39
Y591
D
F
Q
M
Y
A
K
Y
C
Q
N
K
P
R
S
Site 40
T600
Q
N
K
P
R
S
E
T
I
W
R
K
Y
S
E
Site 41
Y605
S
E
T
I
W
R
K
Y
S
E
C
A
F
F
Q
Site 42
S626
K
H
R
L
R
L
D
S
Y
L
L
K
P
V
Q
Site 43
Y627
H
R
L
R
L
D
S
Y
L
L
K
P
V
Q
R
Site 44
T636
L
K
P
V
Q
R
I
T
K
Y
Q
L
L
L
K
Site 45
Y638
P
V
Q
R
I
T
K
Y
Q
L
L
L
K
E
L
Site 46
Y648
L
L
K
E
L
L
K
Y
S
K
D
C
E
G
S
Site 47
S649
L
K
E
L
L
K
Y
S
K
D
C
E
G
S
A
Site 48
S655
Y
S
K
D
C
E
G
S
A
L
L
K
K
A
L
Site 49
S671
A
M
L
D
L
L
K
S
V
N
D
S
M
H
Q
Site 50
S675
L
L
K
S
V
N
D
S
M
H
Q
I
A
I
N
Site 51
S742
F
C
K
R
R
V
E
S
G
E
G
S
D
R
Y
Site 52
S746
R
V
E
S
G
E
G
S
D
R
Y
P
S
Y
S
Site 53
Y749
S
G
E
G
S
D
R
Y
P
S
Y
S
F
K
H
Site 54
Y752
G
S
D
R
Y
P
S
Y
S
F
K
H
C
W
K
Site 55
T766
K
M
D
E
V
G
I
T
E
Y
V
K
G
D
N
Site 56
Y768
D
E
V
G
I
T
E
Y
V
K
G
D
N
R
K
Site 57
Y780
N
R
K
F
E
I
W
Y
G
E
K
E
E
V
Y
Site 58
Y787
Y
G
E
K
E
E
V
Y
I
V
Q
A
S
N
V
Site 59
T816
L
K
Q
Q
E
L
L
T
V
K
K
R
K
Q
Q
Site 60
T827
R
K
Q
Q
D
Q
L
T
E
R
D
K
F
Q
I
Site 61
S835
E
R
D
K
F
Q
I
S
L
Q
Q
N
D
E
K
Site 62
T853
A
F
I
S
T
E
E
T
E
L
E
H
T
S
T
Site 63
T858
E
E
T
E
L
E
H
T
S
T
V
V
E
V
C
Site 64
T860
T
E
L
E
H
T
S
T
V
V
E
V
C
E
A
Site 65
S883
N
T
V
W
T
E
A
S
Q
S
A
E
I
S
E
Site 66
S885
V
W
T
E
A
S
Q
S
A
E
I
S
E
E
P
Site 67
S889
A
S
Q
S
A
E
I
S
E
E
P
A
E
W
S
Site 68
Y899
P
A
E
W
S
S
N
Y
F
Y
P
T
Y
D
E
Site 69
Y901
E
W
S
S
N
Y
F
Y
P
T
Y
D
E
N
E
Site 70
Y904
S
N
Y
F
Y
P
T
Y
D
E
N
E
E
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation