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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLU
Full Name:
Clusterin
Alias:
Aging-associated gene 4 protein;Apolipoprotein J;Complement cytolysis inhibitor;Complement-associated protein SP-40,40;Ku70-binding protein 1;NA1/NA2;Testosterone-repressed prostate message 2;ApoJalpha;Complement cytolysis inhibitor a chain;ApoJbeta
Type:
Mass (Da):
52495
Number AA:
449
UniProt ID:
P10909
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
G
Q
V
L
G
D
Q
T
V
S
D
N
E
L
Q
Site 2
S27
V
L
G
D
Q
T
V
S
D
N
E
L
Q
E
M
Site 3
S39
Q
E
M
S
N
Q
G
S
K
Y
V
N
K
E
I
Site 4
Y41
M
S
N
Q
G
S
K
Y
V
N
K
E
I
Q
N
Site 5
T58
N
G
V
K
Q
I
K
T
L
I
E
K
T
N
E
Site 6
T69
K
T
N
E
E
R
K
T
L
L
S
N
L
E
E
Site 7
S72
E
E
R
K
T
L
L
S
N
L
E
E
A
K
K
Site 8
T88
K
E
D
A
L
N
E
T
R
E
S
E
T
K
L
Site 9
S91
A
L
N
E
T
R
E
S
E
T
K
L
K
E
L
Site 10
Y125
K
Q
T
C
M
K
F
Y
A
R
V
C
R
S
G
Site 11
S131
F
Y
A
R
V
C
R
S
G
S
G
L
V
G
R
Site 12
S133
A
R
V
C
R
S
G
S
G
L
V
G
R
Q
L
Site 13
Y151
L
N
Q
S
S
P
F
Y
F
W
M
N
G
D
R
Site 14
S161
M
N
G
D
R
I
D
S
L
L
E
N
D
R
Q
Site 15
T170
L
E
N
D
R
Q
Q
T
H
M
L
D
V
M
Q
Site 16
S181
D
V
M
Q
D
H
F
S
R
A
S
S
I
I
D
Site 17
S184
Q
D
H
F
S
R
A
S
S
I
I
D
E
L
F
Site 18
S185
D
H
F
S
R
A
S
S
I
I
D
E
L
F
Q
Site 19
T197
L
F
Q
D
R
F
F
T
R
E
P
Q
D
T
Y
Site 20
T203
F
T
R
E
P
Q
D
T
Y
H
Y
L
P
F
S
Site 21
Y204
T
R
E
P
Q
D
T
Y
H
Y
L
P
F
S
L
Site 22
Y206
E
P
Q
D
T
Y
H
Y
L
P
F
S
L
P
H
Site 23
S210
T
Y
H
Y
L
P
F
S
L
P
H
R
R
P
H
Site 24
S223
P
H
F
F
F
P
K
S
R
I
V
R
S
L
M
Site 25
S228
P
K
S
R
I
V
R
S
L
M
P
F
S
P
Y
Site 26
S233
V
R
S
L
M
P
F
S
P
Y
E
P
L
N
F
Site 27
Y235
S
L
M
P
F
S
P
Y
E
P
L
N
F
H
A
Site 28
T272
P
A
F
Q
H
P
P
T
E
F
I
R
E
G
D
Site 29
T283
R
E
G
D
D
D
R
T
V
C
R
E
I
R
H
Site 30
S310
D
K
C
R
E
I
L
S
V
D
C
S
T
N
N
Site 31
S314
E
I
L
S
V
D
C
S
T
N
N
P
S
Q
A
Site 32
T315
I
L
S
V
D
C
S
T
N
N
P
S
Q
A
K
Site 33
S319
D
C
S
T
N
N
P
S
Q
A
K
L
R
R
E
Site 34
S330
L
R
R
E
L
D
E
S
L
Q
V
A
E
R
L
Site 35
T338
L
Q
V
A
E
R
L
T
R
K
Y
N
E
L
L
Site 36
Y341
A
E
R
L
T
R
K
Y
N
E
L
L
K
S
Y
Site 37
S357
W
K
M
L
N
T
S
S
L
L
E
Q
L
N
E
Site 38
T376
V
S
R
L
A
N
L
T
Q
G
E
D
Q
Y
Y
Site 39
Y382
L
T
Q
G
E
D
Q
Y
Y
L
R
V
T
T
V
Site 40
Y383
T
Q
G
E
D
Q
Y
Y
L
R
V
T
T
V
A
Site 41
T387
D
Q
Y
Y
L
R
V
T
T
V
A
S
H
T
S
Site 42
T388
Q
Y
Y
L
R
V
T
T
V
A
S
H
T
S
D
Site 43
S391
L
R
V
T
T
V
A
S
H
T
S
D
S
D
V
Site 44
T393
V
T
T
V
A
S
H
T
S
D
S
D
V
P
S
Site 45
S394
T
T
V
A
S
H
T
S
D
S
D
V
P
S
G
Site 46
S396
V
A
S
H
T
S
D
S
D
V
P
S
G
V
T
Site 47
T418
D
S
D
P
I
T
V
T
V
P
V
E
V
S
R
Site 48
T433
K
N
P
K
F
M
E
T
V
A
E
K
A
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation