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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALPPL2
Full Name:
Alkaline phosphatase, placental-like
Alias:
ALPPL
Type:
Enzyme - Phosphatase, metabolite; membrane bound
Mass (Da):
57377
Number AA:
532
UniProt ID:
P10696
International Prot ID:
IPI00290380
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004035
GO:0000287
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0016310
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T86
K
D
K
L
G
P
E
T
F
L
A
M
D
R
F
Site 2
S99
R
F
P
Y
V
A
L
S
K
T
Y
S
V
D
K
Site 3
T101
P
Y
V
A
L
S
K
T
Y
S
V
D
K
H
V
Site 4
S103
V
A
L
S
K
T
Y
S
V
D
K
H
V
P
D
Site 5
S111
V
D
K
H
V
P
D
S
G
A
T
A
T
A
Y
Site 6
S132
N
F
Q
T
I
G
L
S
A
A
A
R
F
N
Q
Site 7
S161
R
A
K
K
A
G
K
S
V
G
V
V
T
T
T
Site 8
T167
K
S
V
G
V
V
T
T
T
R
V
Q
H
A
S
Site 9
S174
T
T
R
V
Q
H
A
S
P
A
G
A
Y
A
H
Site 10
T182
P
A
G
A
Y
A
H
T
V
N
R
N
W
Y
S
Site 11
Y188
H
T
V
N
R
N
W
Y
S
D
A
D
V
P
A
Site 12
S189
T
V
N
R
N
W
Y
S
D
A
D
V
P
A
S
Site 13
S196
S
D
A
D
V
P
A
S
A
R
Q
E
G
C
Q
Site 14
T207
E
G
C
Q
D
I
A
T
Q
L
I
S
N
M
D
Site 15
Y225
I
L
G
G
G
R
K
Y
M
F
P
M
G
T
P
Site 16
T231
K
Y
M
F
P
M
G
T
P
D
P
E
Y
P
D
Site 17
Y236
M
G
T
P
D
P
E
Y
P
D
D
Y
S
Q
G
Site 18
Y240
D
P
E
Y
P
D
D
Y
S
Q
G
G
T
R
L
Site 19
S241
P
E
Y
P
D
D
Y
S
Q
G
G
T
R
L
D
Site 20
Y265
A
K
H
Q
G
A
R
Y
V
W
N
R
T
E
L
Site 21
S276
R
T
E
L
L
Q
A
S
L
D
P
S
V
T
H
Site 22
Y295
F
E
P
G
D
M
K
Y
E
I
H
R
D
S
T
Site 23
S301
K
Y
E
I
H
R
D
S
T
L
D
P
S
L
M
Site 24
T302
Y
E
I
H
R
D
S
T
L
D
P
S
L
M
E
Site 25
S306
R
D
S
T
L
D
P
S
L
M
E
M
T
E
A
Site 26
Y344
G
H
H
E
S
R
A
Y
R
A
L
T
E
T
I
Site 27
T348
S
R
A
Y
R
A
L
T
E
T
I
M
F
D
D
Site 28
T364
I
E
R
A
G
Q
L
T
S
E
E
D
T
L
S
Site 29
S365
E
R
A
G
Q
L
T
S
E
E
D
T
L
S
L
Site 30
T369
Q
L
T
S
E
E
D
T
L
S
L
V
T
A
D
Site 31
S371
T
S
E
E
D
T
L
S
L
V
T
A
D
H
S
Site 32
S382
A
D
H
S
H
V
F
S
F
G
G
Y
P
L
R
Site 33
Y407
K
A
R
D
R
K
A
Y
T
V
L
L
Y
G
N
Site 34
T408
A
R
D
R
K
A
Y
T
V
L
L
Y
G
N
G
Site 35
Y412
K
A
Y
T
V
L
L
Y
G
N
G
P
G
Y
V
Site 36
Y418
L
Y
G
N
G
P
G
Y
V
L
K
D
G
A
R
Site 37
T429
D
G
A
R
P
D
V
T
E
S
E
S
G
S
P
Site 38
S431
A
R
P
D
V
T
E
S
E
S
G
S
P
E
Y
Site 39
S433
P
D
V
T
E
S
E
S
G
S
P
E
Y
R
Q
Site 40
S435
V
T
E
S
E
S
G
S
P
E
Y
R
Q
Q
S
Site 41
Y438
S
E
S
G
S
P
E
Y
R
Q
Q
S
A
V
P
Site 42
S442
S
P
E
Y
R
Q
Q
S
A
V
P
L
D
G
E
Site 43
T501
D
L
A
P
R
A
G
T
T
D
A
A
H
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation