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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPP1
Full Name:
Osteopontin
Alias:
BNSP; Bone sialoprotein 1; BSPI; Early T-lymphocyte activation 1; ETA-1; Nephropontin; OPN; OSTP; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin
Type:
Mass (Da):
35423
Number AA:
314
UniProt ID:
P10451
International Prot ID:
IPI00021000
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005125
GO:0005178
PhosphoSite+
KinaseNET
Biological Process:
GO:0031214
GO:0007155
GO:0046697
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
I
P
V
K
Q
A
D
S
G
S
S
E
E
K
Q
Site 2
S26
V
K
Q
A
D
S
G
S
S
E
E
K
Q
L
Y
Site 3
S27
K
Q
A
D
S
G
S
S
E
E
K
Q
L
Y
N
Site 4
Y33
S
S
E
E
K
Q
L
Y
N
K
Y
P
D
A
V
Site 5
Y36
E
K
Q
L
Y
N
K
Y
P
D
A
V
A
T
W
Site 6
S49
T
W
L
N
P
D
P
S
Q
K
Q
N
L
L
A
Site 7
S62
L
A
P
Q
N
A
V
S
S
E
E
T
N
D
F
Site 8
S63
A
P
Q
N
A
V
S
S
E
E
T
N
D
F
K
Site 9
T66
N
A
V
S
S
E
E
T
N
D
F
K
Q
E
T
Site 10
T73
T
N
D
F
K
Q
E
T
L
P
S
K
S
N
E
Site 11
S76
F
K
Q
E
T
L
P
S
K
S
N
E
S
H
D
Site 12
S78
Q
E
T
L
P
S
K
S
N
E
S
H
D
H
M
Site 13
S81
L
P
S
K
S
N
E
S
H
D
H
M
D
D
M
Site 14
S99
D
D
D
D
H
V
D
S
Q
D
S
I
D
S
N
Site 15
S102
D
H
V
D
S
Q
D
S
I
D
S
N
D
S
D
Site 16
S105
D
S
Q
D
S
I
D
S
N
D
S
D
D
V
D
Site 17
S108
D
S
I
D
S
N
D
S
D
D
V
D
D
T
D
Site 18
T114
D
S
D
D
V
D
D
T
D
D
S
H
Q
S
D
Site 19
S117
D
V
D
D
T
D
D
S
H
Q
S
D
E
S
H
Site 20
S120
D
T
D
D
S
H
Q
S
D
E
S
H
H
S
D
Site 21
S123
D
S
H
Q
S
D
E
S
H
H
S
D
E
S
D
Site 22
S126
Q
S
D
E
S
H
H
S
D
E
S
D
E
L
V
Site 23
S129
E
S
H
H
S
D
E
S
D
E
L
V
T
D
F
Site 24
T134
D
E
S
D
E
L
V
T
D
F
P
T
D
L
P
Site 25
T138
E
L
V
T
D
F
P
T
D
L
P
A
T
E
V
Site 26
T143
F
P
T
D
L
P
A
T
E
V
F
T
P
V
V
Site 27
T147
L
P
A
T
E
V
F
T
P
V
V
P
T
V
D
Site 28
T152
V
F
T
P
V
V
P
T
V
D
T
Y
D
G
R
Site 29
T155
P
V
V
P
T
V
D
T
Y
D
G
R
G
D
S
Site 30
Y156
V
V
P
T
V
D
T
Y
D
G
R
G
D
S
V
Site 31
S162
T
Y
D
G
R
G
D
S
V
V
Y
G
L
R
S
Site 32
Y165
G
R
G
D
S
V
V
Y
G
L
R
S
K
S
K
Site 33
S169
S
V
V
Y
G
L
R
S
K
S
K
K
F
R
R
Site 34
S171
V
Y
G
L
R
S
K
S
K
K
F
R
R
P
D
Site 35
Y181
F
R
R
P
D
I
Q
Y
P
D
A
T
D
E
D
Site 36
T185
D
I
Q
Y
P
D
A
T
D
E
D
I
T
S
H
Site 37
S191
A
T
D
E
D
I
T
S
H
M
E
S
E
E
L
Site 38
S195
D
I
T
S
H
M
E
S
E
E
L
N
G
A
Y
Site 39
Y202
S
E
E
L
N
G
A
Y
K
A
I
P
V
A
Q
Site 40
S215
A
Q
D
L
N
A
P
S
D
W
D
S
R
G
K
Site 41
S219
N
A
P
S
D
W
D
S
R
G
K
D
S
Y
E
Site 42
S224
W
D
S
R
G
K
D
S
Y
E
T
S
Q
L
D
Site 43
Y225
D
S
R
G
K
D
S
Y
E
T
S
Q
L
D
D
Site 44
T227
R
G
K
D
S
Y
E
T
S
Q
L
D
D
Q
S
Site 45
S228
G
K
D
S
Y
E
T
S
Q
L
D
D
Q
S
A
Site 46
S234
T
S
Q
L
D
D
Q
S
A
E
T
H
S
H
K
Site 47
S239
D
Q
S
A
E
T
H
S
H
K
Q
S
R
L
Y
Site 48
S243
E
T
H
S
H
K
Q
S
R
L
Y
K
R
K
A
Site 49
Y246
S
H
K
Q
S
R
L
Y
K
R
K
A
N
D
E
Site 50
S254
K
R
K
A
N
D
E
S
N
E
H
S
D
V
I
Site 51
S258
N
D
E
S
N
E
H
S
D
V
I
D
S
Q
E
Site 52
S263
E
H
S
D
V
I
D
S
Q
E
L
S
K
V
S
Site 53
S267
V
I
D
S
Q
E
L
S
K
V
S
R
E
F
H
Site 54
S270
S
Q
E
L
S
K
V
S
R
E
F
H
S
H
E
Site 55
S275
K
V
S
R
E
F
H
S
H
E
F
H
S
H
E
Site 56
S280
F
H
S
H
E
F
H
S
H
E
D
M
L
V
V
Site 57
S291
M
L
V
V
D
P
K
S
K
E
E
D
K
H
L
Site 58
S303
K
H
L
K
F
R
I
S
H
E
L
D
S
A
S
Site 59
S308
R
I
S
H
E
L
D
S
A
S
S
E
V
N
_
Site 60
S310
S
H
E
L
D
S
A
S
S
E
V
N
_
_
_
Site 61
S311
H
E
L
D
S
A
S
S
E
V
N
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation