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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACR
Full Name:
Acrosin
Alias:
ACRO; EC 3.4.21.10; Preproacrosin
Type:
Protease; EC 3.4.21.10
Mass (Da):
45847
Number AA:
421
UniProt ID:
P10323
International Prot ID:
IPI00289614
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043159
GO:0043234
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0004040
GO:0005507
PhosphoSite+
KinaseNET
Biological Process:
GO:0002077
GO:0007190
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y65
V
S
L
Q
I
F
T
Y
N
S
H
R
Y
H
T
Site 2
Y70
F
T
Y
N
S
H
R
Y
H
T
C
G
G
S
L
Site 3
T72
Y
N
S
H
R
Y
H
T
C
G
G
S
L
L
N
Site 4
S76
R
Y
H
T
C
G
G
S
L
L
N
S
R
W
V
Site 5
Y110
F
G
A
K
E
I
T
Y
G
N
N
K
P
V
K
Site 6
Y124
K
A
P
L
Q
E
R
Y
V
E
K
I
I
I
H
Site 7
Y134
K
I
I
I
H
E
K
Y
N
S
A
T
E
G
N
Site 8
S136
I
I
H
E
K
Y
N
S
A
T
E
G
N
D
I
Site 9
S174
K
A
G
L
P
R
G
S
Q
S
C
W
V
A
G
Site 10
S193
E
E
K
A
P
R
P
S
S
I
L
M
E
A
R
Site 11
S194
E
K
A
P
R
P
S
S
I
L
M
E
A
R
V
Site 12
Y215
L
C
N
S
T
Q
W
Y
N
G
R
V
Q
P
T
Site 13
Y228
P
T
N
V
C
A
G
Y
P
V
G
K
I
D
T
Site 14
T235
Y
P
V
G
K
I
D
T
C
Q
G
D
S
G
G
Site 15
S249
G
P
L
M
C
K
D
S
K
E
S
A
Y
V
V
Site 16
Y254
K
D
S
K
E
S
A
Y
V
V
V
G
I
T
S
Site 17
Y275
R
A
K
R
P
G
I
Y
T
A
T
W
P
Y
L
Site 18
T276
A
K
R
P
G
I
Y
T
A
T
W
P
Y
L
N
Site 19
Y281
I
Y
T
A
T
W
P
Y
L
N
W
I
A
S
K
Site 20
S299
N
A
L
R
M
I
Q
S
A
T
P
P
P
P
T
Site 21
T301
L
R
M
I
Q
S
A
T
P
P
P
P
T
T
R
Site 22
T306
S
A
T
P
P
P
P
T
T
R
P
P
P
I
R
Site 23
T307
A
T
P
P
P
P
T
T
R
P
P
P
I
R
P
Site 24
S317
P
P
I
R
P
P
F
S
H
P
I
S
A
H
L
Site 25
Y327
I
S
A
H
L
P
W
Y
F
Q
P
P
P
R
P
Site 26
S349
A
Q
P
R
P
P
P
S
P
P
P
P
P
P
P
Site 27
S359
P
P
P
P
P
P
A
S
P
L
P
P
P
P
P
Site 28
T371
P
P
P
P
P
P
P
T
P
S
S
T
T
K
L
Site 29
S373
P
P
P
P
P
T
P
S
S
T
T
K
L
P
Q
Site 30
S374
P
P
P
P
T
P
S
S
T
T
K
L
P
Q
G
Site 31
S383
T
K
L
P
Q
G
L
S
F
A
K
R
L
Q
Q
Site 32
Y400
E
V
L
K
G
K
T
Y
S
D
G
K
N
H
Y
Site 33
S401
V
L
K
G
K
T
Y
S
D
G
K
N
H
Y
D
Site 34
T412
N
H
Y
D
M
E
T
T
E
L
P
E
L
T
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation