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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GAA
Full Name:
Lysosomal alpha-glucosidase
Alias:
Acid maltase;Aglucosidase alfa
Type:
Mass (Da):
105319
Number AA:
952
UniProt ID:
P10253
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S45
V
P
R
E
L
S
G
S
S
P
V
L
E
E
T
Site 2
S46
P
R
E
L
S
G
S
S
P
V
L
E
E
T
H
Site 3
T80
G
R
P
R
A
V
P
T
Q
C
D
V
P
P
N
Site 4
Y133
W
C
F
F
P
P
S
Y
P
S
Y
K
L
E
N
Site 5
Y136
F
P
P
S
Y
P
S
Y
K
L
E
N
L
S
S
Site 6
S142
S
Y
K
L
E
N
L
S
S
S
E
M
G
Y
T
Site 7
S143
Y
K
L
E
N
L
S
S
S
E
M
G
Y
T
A
Site 8
S144
K
L
E
N
L
S
S
S
E
M
G
Y
T
A
T
Site 9
Y148
L
S
S
S
E
M
G
Y
T
A
T
L
T
R
T
Site 10
T149
S
S
S
E
M
G
Y
T
A
T
L
T
R
T
T
Site 11
T151
S
E
M
G
Y
T
A
T
L
T
R
T
T
P
T
Site 12
T156
T
A
T
L
T
R
T
T
P
T
F
F
P
K
D
Site 13
T158
T
L
T
R
T
T
P
T
F
F
P
K
D
I
L
Site 14
Y191
K
D
P
A
N
R
R
Y
E
V
P
L
E
T
P
Site 15
T197
R
Y
E
V
P
L
E
T
P
H
V
H
S
R
A
Site 16
S202
L
E
T
P
H
V
H
S
R
A
P
S
P
L
Y
Site 17
S206
H
V
H
S
R
A
P
S
P
L
Y
S
V
E
F
Site 18
Y209
S
R
A
P
S
P
L
Y
S
V
E
F
S
E
E
Site 19
S210
R
A
P
S
P
L
Y
S
V
E
F
S
E
E
P
Site 20
S249
A
D
Q
F
L
Q
L
S
T
S
L
P
S
Q
Y
Site 21
T250
D
Q
F
L
Q
L
S
T
S
L
P
S
Q
Y
I
Site 22
S251
Q
F
L
Q
L
S
T
S
L
P
S
Q
Y
I
T
Site 23
T258
S
L
P
S
Q
Y
I
T
G
L
A
E
H
L
S
Site 24
T277
S
T
S
W
T
R
I
T
L
W
N
R
D
L
A
Site 25
T286
W
N
R
D
L
A
P
T
P
G
A
N
L
Y
G
Site 26
Y292
P
T
P
G
A
N
L
Y
G
S
H
P
F
Y
L
Site 27
Y298
L
Y
G
S
H
P
F
Y
L
A
L
E
D
G
G
Site 28
S325
M
D
V
V
L
Q
P
S
P
A
L
S
W
R
S
Site 29
S329
L
Q
P
S
P
A
L
S
W
R
S
T
G
G
I
Site 30
S349
F
L
G
P
E
P
K
S
V
V
Q
Q
Y
L
D
Site 31
Y354
P
K
S
V
V
Q
Q
Y
L
D
V
V
G
Y
P
Site 32
Y360
Q
Y
L
D
V
V
G
Y
P
F
M
P
P
Y
W
Site 33
Y378
F
H
L
C
R
W
G
Y
S
S
T
A
I
T
R
Site 34
Y407
V
Q
W
N
D
L
D
Y
M
D
S
R
R
D
F
Site 35
T415
M
D
S
R
R
D
F
T
F
N
K
D
G
F
R
Site 36
Y438
L
H
Q
G
G
R
R
Y
M
M
I
V
D
P
A
Site 37
S449
V
D
P
A
I
S
S
S
G
P
A
G
S
Y
R
Site 38
S454
S
S
S
G
P
A
G
S
Y
R
P
Y
D
E
G
Site 39
Y458
P
A
G
S
Y
R
P
Y
D
E
G
L
R
R
G
Site 40
T469
L
R
R
G
V
F
I
T
N
E
T
G
Q
P
L
Site 41
T491
S
T
A
F
P
D
F
T
N
P
T
A
L
A
W
Site 42
S529
P
S
N
F
I
R
G
S
E
D
G
C
P
N
N
Site 43
Y543
N
E
L
E
N
P
P
Y
V
P
G
V
V
G
G
Site 44
T567
S
S
H
Q
F
L
S
T
H
Y
N
L
H
N
L
Site 45
T578
L
H
N
L
Y
G
L
T
E
A
I
A
S
H
R
Site 46
S599
G
T
R
P
F
V
I
S
R
S
T
F
A
G
H
Site 47
S601
R
P
F
V
I
S
R
S
T
F
A
G
H
G
R
Site 48
T602
P
F
V
I
S
R
S
T
F
A
G
H
G
R
Y
Site 49
S626
S
S
W
E
Q
L
A
S
S
V
P
E
I
L
Q
Site 50
S627
S
W
E
Q
L
A
S
S
V
P
E
I
L
Q
F
Site 51
S676
P
F
M
R
N
H
N
S
L
L
S
L
P
Q
E
Site 52
S679
R
N
H
N
S
L
L
S
L
P
Q
E
P
Y
S
Site 53
S686
S
L
P
Q
E
P
Y
S
F
S
E
P
A
Q
Q
Site 54
S688
P
Q
E
P
Y
S
F
S
E
P
A
Q
Q
A
M
Site 55
T737
E
F
P
K
D
S
S
T
W
T
V
D
H
Q
L
Site 56
T739
P
K
D
S
S
T
W
T
V
D
H
Q
L
L
W
Site 57
Y766
G
K
A
E
V
T
G
Y
F
P
L
G
T
W
Y
Site 58
T834
Q
G
P
G
L
T
T
T
E
S
R
Q
Q
P
M
Site 59
S836
P
G
L
T
T
T
E
S
R
Q
Q
P
M
A
L
Site 60
S864
L
F
W
D
D
G
E
S
L
E
V
L
E
R
G
Site 61
T884
I
F
L
A
R
N
N
T
I
V
N
E
L
V
R
Site 62
T893
V
N
E
L
V
R
V
T
S
E
G
A
G
L
Q
Site 63
S894
N
E
L
V
R
V
T
S
E
G
A
G
L
Q
L
Site 64
S918
T
A
P
Q
Q
V
L
S
N
G
V
P
V
S
N
Site 65
S924
L
S
N
G
V
P
V
S
N
F
T
Y
S
P
D
Site 66
Y928
V
P
V
S
N
F
T
Y
S
P
D
T
K
V
L
Site 67
S929
P
V
S
N
F
T
Y
S
P
D
T
K
V
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation