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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HKR2
Full Name:
Zinc finger and SCAN domain-containing protein 22
Alias:
Krueppel-related zinc finger protein 2; Oncogene HKR2; Zinc finger and SCAN domain containing 22; Zinc finger and scan domain-containing protein 22; Zinc finger protein 50; Zinc finger protein 50;Krueppel-related zinc finger protein 2;Protein HKR2; ZNF50; ZSC22
Type:
Transcription factor
Mass (Da):
54561
Number AA:
491
UniProt ID:
P10073
International Prot ID:
IPI00334197
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
I
P
K
H
S
L
S
P
V
P
W
E
Site 2
S9
A
I
P
K
H
S
L
S
P
V
P
W
E
E
D
Site 3
S17
P
V
P
W
E
E
D
S
F
L
Q
V
K
V
E
Site 4
S30
V
E
E
E
E
E
A
S
L
S
Q
G
G
E
S
Site 5
S38
L
S
Q
G
G
E
S
S
H
D
H
I
A
H
S
Site 6
S45
S
H
D
H
I
A
H
S
E
A
A
R
L
R
F
Site 7
Y57
L
R
F
R
H
F
R
Y
E
E
A
S
G
P
H
Site 8
S61
H
F
R
Y
E
E
A
S
G
P
H
E
A
L
A
Site 9
S113
Q
A
W
V
G
A
Q
S
P
K
S
G
E
E
A
Site 10
S116
V
G
A
Q
S
P
K
S
G
E
E
A
A
V
L
Site 11
S146
G
A
E
P
T
E
A
S
C
K
Q
S
D
L
G
Site 12
S150
T
E
A
S
C
K
Q
S
D
L
G
E
S
E
P
Site 13
S158
D
L
G
E
S
E
P
S
N
V
T
E
T
L
M
Site 14
S183
K
A
C
E
P
E
G
S
S
E
R
S
G
L
S
Site 15
S184
A
C
E
P
E
G
S
S
E
R
S
G
L
S
G
Site 16
S187
P
E
G
S
S
E
R
S
G
L
S
G
E
I
W
Site 17
S190
S
S
E
R
S
G
L
S
G
E
I
W
T
K
S
Site 18
T216
G
P
Y
K
D
V
P
T
D
Q
R
G
R
E
S
Site 19
S223
T
D
Q
R
G
R
E
S
G
A
S
R
N
S
S
Site 20
S226
R
G
R
E
S
G
A
S
R
N
S
S
S
A
W
Site 21
S229
E
S
G
A
S
R
N
S
S
S
A
W
P
N
L
Site 22
S230
S
G
A
S
R
N
S
S
S
A
W
P
N
L
T
Site 23
S231
G
A
S
R
N
S
S
S
A
W
P
N
L
T
S
Site 24
T237
S
S
A
W
P
N
L
T
S
Q
E
K
P
P
S
Site 25
S238
S
A
W
P
N
L
T
S
Q
E
K
P
P
S
E
Site 26
S244
T
S
Q
E
K
P
P
S
E
D
K
F
D
L
V
Site 27
Y254
K
F
D
L
V
D
A
Y
G
T
E
P
P
Y
T
Site 28
T256
D
L
V
D
A
Y
G
T
E
P
P
Y
T
Y
S
Site 29
Y260
A
Y
G
T
E
P
P
Y
T
Y
S
G
K
R
S
Site 30
T261
Y
G
T
E
P
P
Y
T
Y
S
G
K
R
S
S
Site 31
Y262
G
T
E
P
P
Y
T
Y
S
G
K
R
S
S
K
Site 32
S263
T
E
P
P
Y
T
Y
S
G
K
R
S
S
K
C
Site 33
S267
Y
T
Y
S
G
K
R
S
S
K
C
R
E
C
R
Site 34
S268
T
Y
S
G
K
R
S
S
K
C
R
E
C
R
K
Site 35
S279
E
C
R
K
M
F
Q
S
A
S
A
L
E
A
H
Site 36
S281
R
K
M
F
Q
S
A
S
A
L
E
A
H
Q
K
Site 37
T289
A
L
E
A
H
Q
K
T
H
S
R
K
T
P
Y
Site 38
T294
Q
K
T
H
S
R
K
T
P
Y
A
C
S
E
C
Site 39
Y296
T
H
S
R
K
T
P
Y
A
C
S
E
C
G
K
Site 40
S299
R
K
T
P
Y
A
C
S
E
C
G
K
A
F
S
Site 41
S306
S
E
C
G
K
A
F
S
R
S
T
H
L
A
Q
Site 42
T309
G
K
A
F
S
R
S
T
H
L
A
Q
H
Q
V
Site 43
S334
K
E
C
G
K
A
F
S
R
V
T
H
L
T
Q
Site 44
T337
G
K
A
F
S
R
V
T
H
L
T
Q
H
Q
R
Site 45
T347
T
Q
H
Q
R
I
H
T
G
E
K
P
Y
K
C
Site 46
Y352
I
H
T
G
E
K
P
Y
K
C
G
E
C
G
K
Site 47
T360
K
C
G
E
C
G
K
T
F
S
R
S
T
H
L
Site 48
S362
G
E
C
G
K
T
F
S
R
S
T
H
L
T
Q
Site 49
S364
C
G
K
T
F
S
R
S
T
H
L
T
Q
H
Q
Site 50
T365
G
K
T
F
S
R
S
T
H
L
T
Q
H
Q
R
Site 51
T368
F
S
R
S
T
H
L
T
Q
H
Q
R
V
H
T
Site 52
T375
T
Q
H
Q
R
V
H
T
G
E
R
P
Y
E
C
Site 53
Y380
V
H
T
G
E
R
P
Y
E
C
D
A
C
G
K
Site 54
S390
D
A
C
G
K
A
F
S
Q
S
T
H
L
T
Q
Site 55
T396
F
S
Q
S
T
H
L
T
Q
H
Q
R
I
H
T
Site 56
S421
G
R
A
F
S
D
C
S
A
L
I
R
H
L
R
Site 57
S431
I
R
H
L
R
I
H
S
G
E
K
P
Y
Q
C
Site 58
Y436
I
H
S
G
E
K
P
Y
Q
C
K
V
C
P
K
Site 59
S449
P
K
A
F
A
Q
S
S
S
L
I
E
H
Q
R
Site 60
S450
K
A
F
A
Q
S
S
S
L
I
E
H
Q
R
I
Site 61
T459
I
E
H
Q
R
I
H
T
G
E
K
P
Y
K
C
Site 62
S467
G
E
K
P
Y
K
C
S
D
C
G
K
A
F
S
Site 63
S474
S
D
C
G
K
A
F
S
R
S
S
A
L
M
V
Site 64
S477
G
K
A
F
S
R
S
S
A
L
M
V
H
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation