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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HKR1
Full Name:
Krueppel-related zinc finger protein 1
Alias:
Protein HKR1;Zinc finger protein 875
Type:
Mass (Da):
75128
Number AA:
659
UniProt ID:
P10072
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
M
V
H
R
Q
T
M
S
C
S
G
A
G
G
I
Site 2
S24
H
R
Q
T
M
S
C
S
G
A
G
G
I
T
A
Site 3
Y41
A
F
R
D
V
A
V
Y
F
T
Q
E
E
W
R
Site 4
S51
Q
E
E
W
R
L
L
S
P
A
Q
R
T
L
H
Site 5
S71
E
T
Y
N
H
L
V
S
L
E
I
P
S
S
K
Site 6
S77
V
S
L
E
I
P
S
S
K
P
K
L
I
A
Q
Site 7
S106
P
L
D
L
C
P
E
S
K
P
E
I
Q
L
S
Site 8
S121
P
S
C
P
L
I
F
S
S
Q
Q
A
L
S
Q
Site 9
S122
S
C
P
L
I
F
S
S
Q
Q
A
L
S
Q
H
Site 10
S127
F
S
S
Q
Q
A
L
S
Q
H
V
W
L
S
H
Site 11
S140
S
H
L
S
Q
L
F
S
S
L
W
A
G
N
P
Site 12
Y154
P
L
H
L
G
K
H
Y
P
E
D
Q
K
Q
Q
Site 13
S180
W
I
Q
E
G
E
D
S
R
L
L
F
G
R
V
Site 14
S188
R
L
L
F
G
R
V
S
K
N
G
T
S
K
A
Site 15
T192
G
R
V
S
K
N
G
T
S
K
A
L
S
S
P
Site 16
S193
R
V
S
K
N
G
T
S
K
A
L
S
S
P
P
Site 17
S197
N
G
T
S
K
A
L
S
S
P
P
E
E
Q
Q
Site 18
S198
G
T
S
K
A
L
S
S
P
P
E
E
Q
Q
P
Site 19
T213
A
Q
S
K
E
D
N
T
V
V
D
I
G
S
S
Site 20
S220
T
V
V
D
I
G
S
S
P
E
R
R
A
D
L
Site 21
Y247
S
G
F
G
E
I
K
Y
E
E
F
G
P
G
F
Site 22
S258
G
P
G
F
I
K
E
S
N
L
L
S
L
Q
K
Site 23
S262
I
K
E
S
N
L
L
S
L
Q
K
T
Q
T
G
Site 24
T266
N
L
L
S
L
Q
K
T
Q
T
G
E
T
P
Y
Site 25
T268
L
S
L
Q
K
T
Q
T
G
E
T
P
Y
M
Y
Site 26
T271
Q
K
T
Q
T
G
E
T
P
Y
M
Y
T
E
W
Site 27
Y273
T
Q
T
G
E
T
P
Y
M
Y
T
E
W
G
D
Site 28
Y275
T
G
E
T
P
Y
M
Y
T
E
W
G
D
S
F
Site 29
S281
M
Y
T
E
W
G
D
S
F
G
S
M
S
V
L
Site 30
S284
E
W
G
D
S
F
G
S
M
S
V
L
I
K
N
Site 31
S286
G
D
S
F
G
S
M
S
V
L
I
K
N
P
R
Site 32
T294
V
L
I
K
N
P
R
T
H
S
G
G
K
P
Y
Site 33
S296
I
K
N
P
R
T
H
S
G
G
K
P
Y
V
C
Site 34
Y301
T
H
S
G
G
K
P
Y
V
C
R
E
C
G
R
Site 35
T311
R
E
C
G
R
G
F
T
W
K
S
N
L
I
T
Site 36
T318
T
W
K
S
N
L
I
T
H
Q
R
T
H
S
G
Site 37
S324
I
T
H
Q
R
T
H
S
G
E
K
P
Y
V
C
Site 38
Y329
T
H
S
G
E
K
P
Y
V
C
K
D
C
G
R
Site 39
T346
T
W
K
S
N
L
F
T
H
Q
R
T
H
S
G
Site 40
Y357
T
H
S
G
L
K
P
Y
V
C
K
E
C
G
Q
Site 41
S365
V
C
K
E
C
G
Q
S
F
S
L
K
S
N
L
Site 42
S367
K
E
C
G
Q
S
F
S
L
K
S
N
L
I
T
Site 43
S370
G
Q
S
F
S
L
K
S
N
L
I
T
H
Q
R
Site 44
T374
S
L
K
S
N
L
I
T
H
Q
R
A
H
T
G
Site 45
T380
I
T
H
Q
R
A
H
T
G
E
K
P
Y
V
C
Site 46
Y385
A
H
T
G
E
K
P
Y
V
C
R
E
C
G
R
Site 47
S398
G
R
G
F
R
Q
H
S
H
L
V
R
H
K
R
Site 48
S408
V
R
H
K
R
T
H
S
G
E
K
P
Y
I
C
Site 49
Y413
T
H
S
G
E
K
P
Y
I
C
R
E
C
E
Q
Site 50
S423
R
E
C
E
Q
G
F
S
Q
K
S
H
L
I
R
Site 51
S426
E
Q
G
F
S
Q
K
S
H
L
I
R
H
L
R
Site 52
T434
H
L
I
R
H
L
R
T
H
T
G
E
K
P
Y
Site 53
T436
I
R
H
L
R
T
H
T
G
E
K
P
Y
V
C
Site 54
Y441
T
H
T
G
E
K
P
Y
V
C
T
E
C
G
R
Site 55
S451
T
E
C
G
R
H
F
S
W
K
S
N
L
K
T
Site 56
T458
S
W
K
S
N
L
K
T
H
Q
R
T
H
S
G
Site 57
S464
K
T
H
Q
R
T
H
S
G
V
K
P
Y
V
C
Site 58
Y469
T
H
S
G
V
K
P
Y
V
C
L
E
C
G
Q
Site 59
S479
L
E
C
G
Q
C
F
S
L
K
S
N
L
N
K
Site 60
S482
G
Q
C
F
S
L
K
S
N
L
N
K
H
Q
R
Site 61
T492
N
K
H
Q
R
S
H
T
G
E
K
P
F
V
C
Site 62
T507
T
E
C
G
R
G
F
T
R
K
S
T
L
S
T
Site 63
S510
G
R
G
F
T
R
K
S
T
L
S
T
H
Q
R
Site 64
T511
R
G
F
T
R
K
S
T
L
S
T
H
Q
R
T
Site 65
S513
F
T
R
K
S
T
L
S
T
H
Q
R
T
H
S
Site 66
T514
T
R
K
S
T
L
S
T
H
Q
R
T
H
S
G
Site 67
S520
S
T
H
Q
R
T
H
S
G
E
K
P
F
V
C
Site 68
S538
G
R
G
F
N
D
K
S
T
L
I
S
H
Q
R
Site 69
T539
R
G
F
N
D
K
S
T
L
I
S
H
Q
R
T
Site 70
S542
N
D
K
S
T
L
I
S
H
Q
R
T
H
S
G
Site 71
T546
T
L
I
S
H
Q
R
T
H
S
G
E
K
P
F
Site 72
S548
I
S
H
Q
R
T
H
S
G
E
K
P
F
M
C
Site 73
S576
F
R
H
K
R
A
H
S
G
A
F
V
C
R
E
Site 74
T593
Q
G
F
C
A
K
L
T
L
I
K
H
Q
R
A
Site 75
S617
R
E
C
G
Q
G
F
S
R
Q
S
H
L
I
R
Site 76
S620
G
Q
G
F
S
R
Q
S
H
L
I
R
H
Q
R
Site 77
Y635
T
H
S
G
E
K
P
Y
I
C
R
K
C
G
R
Site 78
S645
R
K
C
G
R
G
F
S
R
K
S
N
L
I
R
Site 79
S648
G
R
G
F
S
R
K
S
N
L
I
R
H
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation