KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ASAH2C
Full Name:
Putative neutral ceramidase C
Alias:
N-acylsphingosine amidohydrolase 2C;Non-lysosomal ceramidase C
Type:
Mass (Da):
68749
Number AA:
622
UniProt ID:
P0C7U2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
D
S
E
K
S
S
E
W
R
S
D
V
Site 2
S7
_
M
D
S
E
K
S
S
E
W
R
S
D
V
L
Site 3
S11
E
K
S
S
E
W
R
S
D
V
L
N
R
L
Q
Site 4
S19
D
V
L
N
R
L
Q
S
K
Y
G
S
L
Y
R
Site 5
Y21
L
N
R
L
Q
S
K
Y
G
S
L
Y
R
R
D
Site 6
S23
R
L
Q
S
K
Y
G
S
L
Y
R
R
D
N
V
Site 7
Y25
Q
S
K
Y
G
S
L
Y
R
R
D
N
V
I
L
Site 8
S33
R
R
D
N
V
I
L
S
G
T
H
T
H
S
G
Site 9
T35
D
N
V
I
L
S
G
T
H
T
H
S
G
P
A
Site 10
T37
V
I
L
S
G
T
H
T
H
S
G
P
A
G
Y
Site 11
T61
S
E
G
F
S
N
Q
T
F
Q
H
M
V
T
G
Site 12
S100
D
G
V
Q
I
N
R
S
P
Y
S
Y
L
Q
N
Site 13
Y102
V
Q
I
N
R
S
P
Y
S
Y
L
Q
N
P
Q
Site 14
S103
Q
I
N
R
S
P
Y
S
Y
L
Q
N
P
Q
S
Site 15
Y104
I
N
R
S
P
Y
S
Y
L
Q
N
P
Q
S
E
Site 16
S110
S
Y
L
Q
N
P
Q
S
E
R
A
R
Y
S
S
Site 17
Y115
P
Q
S
E
R
A
R
Y
S
S
N
T
D
K
E
Site 18
S116
Q
S
E
R
A
R
Y
S
S
N
T
D
K
E
M
Site 19
S117
S
E
R
A
R
Y
S
S
N
T
D
K
E
M
I
Site 20
T119
R
A
R
Y
S
S
N
T
D
K
E
M
I
V
L
Site 21
S152
H
P
V
S
M
N
N
S
N
H
L
V
N
S
D
Site 22
S158
N
S
N
H
L
V
N
S
D
N
V
G
Y
A
S
Site 23
Y176
E
Q
E
K
N
K
G
Y
L
P
G
Q
G
P
F
Site 24
S196
S
S
N
L
G
D
V
S
P
N
I
L
G
P
R
Site 25
S216
E
S
C
D
N
A
N
S
T
C
P
I
G
G
P
Site 26
T217
S
C
D
N
A
N
S
T
C
P
I
G
G
P
S
Site 27
S238
P
G
Q
D
M
F
D
S
T
Q
I
I
G
R
A
Site 28
Y247
Q
I
I
G
R
A
M
Y
Q
R
A
K
E
L
Y
Site 29
Y254
Y
Q
R
A
K
E
L
Y
A
S
A
S
Q
E
V
Site 30
S256
R
A
K
E
L
Y
A
S
A
S
Q
E
V
T
G
Site 31
S258
K
E
L
Y
A
S
A
S
Q
E
V
T
G
P
L
Site 32
T262
A
S
A
S
Q
E
V
T
G
P
L
A
S
A
H
Site 33
S287
W
L
N
S
T
H
A
S
K
T
C
K
P
A
L
Site 34
T289
N
S
T
H
A
S
K
T
C
K
P
A
L
G
Y
Site 35
S334
D
Q
I
L
G
K
P
S
E
E
I
K
E
C
H
Site 36
T350
P
K
P
I
L
L
H
T
G
E
L
S
K
P
H
Site 37
S354
L
L
H
T
G
E
L
S
K
P
H
P
W
H
P
Site 38
S387
P
G
E
F
T
T
M
S
G
R
R
L
R
E
A
Site 39
Y421
L
C
N
V
Y
T
H
Y
I
T
T
Y
E
E
Y
Site 40
Y425
Y
T
H
Y
I
T
T
Y
E
E
Y
Q
A
Q
R
Site 41
Y433
E
E
Y
Q
A
Q
R
Y
E
A
A
S
T
I
Y
Site 42
S437
A
Q
R
Y
E
A
A
S
T
I
Y
G
P
H
T
Site 43
T438
Q
R
Y
E
A
A
S
T
I
Y
G
P
H
T
L
Site 44
Y448
G
P
H
T
L
S
A
Y
I
Q
L
F
R
N
L
Site 45
S468
T
D
T
V
A
N
L
S
R
G
P
E
P
P
F
Site 46
T496
D
R
A
P
K
G
R
T
F
G
D
V
L
Q
P
Site 47
Y508
L
Q
P
A
K
P
E
Y
R
V
G
E
V
A
E
Site 48
S526
V
G
A
N
P
K
N
S
V
Q
N
Q
N
H
Q
Site 49
T534
V
Q
N
Q
N
H
Q
T
F
L
T
V
E
K
Y
Site 50
T537
Q
N
H
Q
T
F
L
T
V
E
K
Y
E
A
T
Site 51
Y541
T
F
L
T
V
E
K
Y
E
A
T
S
T
S
W
Site 52
Y562
A
S
W
E
T
R
F
Y
W
H
K
G
L
L
G
Site 53
S571
H
K
G
L
L
G
L
S
N
A
T
V
E
W
H
Site 54
Y592
P
G
I
Y
R
I
R
Y
F
G
H
N
R
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation