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Updated November 2019
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Protein Info
Short Name:
SLFN14
Full Name:
Schlafen family member 14
Alias:
Type:
Mass (Da):
103907
Number AA:
912
UniProt ID:
P0C7P3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
E
S
L
K
T
D
T
E
M
P
Y
P
E
V
Site 2
Y12
K
T
D
T
E
M
P
Y
P
E
V
I
V
D
V
Site 3
S35
N
R
K
K
M
T
N
S
C
L
K
R
S
E
N
Site 4
S40
T
N
S
C
L
K
R
S
E
N
S
R
I
I
R
Site 5
Y69
A
E
I
D
D
K
T
Y
S
Y
Q
C
H
G
L
Site 6
Y71
I
D
D
K
T
Y
S
Y
Q
C
H
G
L
G
Q
Site 7
S83
L
G
Q
D
L
E
T
S
F
Q
K
L
L
P
S
Site 8
S90
S
F
Q
K
L
L
P
S
G
S
Q
K
Y
L
D
Site 9
S92
Q
K
L
L
P
S
G
S
Q
K
Y
L
D
Y
M
Site 10
Y95
L
P
S
G
S
Q
K
Y
L
D
Y
M
Q
Q
G
Site 11
Y98
G
S
Q
K
Y
L
D
Y
M
Q
Q
G
H
N
L
Site 12
S125
S
L
P
L
R
I
C
S
L
R
S
N
L
Y
R
Site 13
Y131
C
S
L
R
S
N
L
Y
R
R
D
V
T
S
A
Site 14
T136
N
L
Y
R
R
D
V
T
S
A
I
N
L
S
A
Site 15
S137
L
Y
R
R
D
V
T
S
A
I
N
L
S
A
S
Site 16
S207
E
K
L
N
F
T
E
S
T
H
V
E
F
K
R
Site 17
T216
H
V
E
F
K
R
F
T
T
K
K
V
I
P
R
Site 18
T217
V
E
F
K
R
F
T
T
K
K
V
I
P
R
I
Site 19
S233
E
M
L
P
H
Y
V
S
A
F
A
N
T
Q
G
Site 20
S251
L
I
G
V
D
D
K
S
K
E
V
V
G
C
K
Site 21
Y300
T
T
K
I
L
N
V
Y
Q
K
D
V
L
D
G
Site 22
S328
V
F
A
E
A
P
D
S
W
I
M
K
D
N
S
Site 23
S335
S
W
I
M
K
D
N
S
V
T
R
L
T
A
E
Site 24
T340
D
N
S
V
T
R
L
T
A
E
Q
W
V
V
M
Site 25
S357
D
T
Q
S
A
P
S
S
L
V
T
D
Y
N
S
Site 26
Y362
P
S
S
L
V
T
D
Y
N
S
C
L
I
S
S
Site 27
S368
D
Y
N
S
C
L
I
S
S
A
S
S
A
R
K
Site 28
S369
Y
N
S
C
L
I
S
S
A
S
S
A
R
K
S
Site 29
S371
S
C
L
I
S
S
A
S
S
A
R
K
S
P
G
Site 30
S372
C
L
I
S
S
A
S
S
A
R
K
S
P
G
Y
Site 31
S376
S
A
S
S
A
R
K
S
P
G
Y
P
I
K
V
Site 32
Y379
S
A
R
K
S
P
G
Y
P
I
K
V
H
K
F
Site 33
S408
E
V
Q
F
K
P
E
S
L
C
K
K
L
F
S
Site 34
S415
S
L
C
K
K
L
F
S
D
H
K
E
L
E
G
Site 35
T426
E
L
E
G
L
M
K
T
L
I
H
P
C
S
Q
Site 36
Y484
N
W
P
G
G
L
E
Y
A
R
N
T
A
H
Q
Site 37
T488
G
L
E
Y
A
R
N
T
A
H
Q
L
K
Q
K
Site 38
T498
Q
L
K
Q
K
L
Q
T
V
G
G
Y
T
G
K
Site 39
S516
I
P
R
L
I
H
L
S
S
T
Q
S
R
P
G
Site 40
S517
P
R
L
I
H
L
S
S
T
Q
S
R
P
G
E
Site 41
T518
R
L
I
H
L
S
S
T
Q
S
R
P
G
E
I
Site 42
S520
I
H
L
S
S
T
Q
S
R
P
G
E
I
P
L
Site 43
Y529
P
G
E
I
P
L
R
Y
P
R
S
Y
R
L
A
Site 44
S532
I
P
L
R
Y
P
R
S
Y
R
L
A
D
E
E
Site 45
Y533
P
L
R
Y
P
R
S
Y
R
L
A
D
E
E
E
Site 46
S560
L
S
S
R
S
L
L
S
D
Q
M
G
C
E
F
Site 47
S580
M
E
Q
S
Q
L
L
S
E
S
L
Q
K
T
R
Site 48
S582
Q
S
Q
L
L
S
E
S
L
Q
K
T
R
E
L
Site 49
T586
L
S
E
S
L
Q
K
T
R
E
L
F
I
Y
C
Site 50
Y592
K
T
R
E
L
F
I
Y
C
F
P
G
V
R
K
Site 51
Y623
C
K
P
K
E
I
L
Y
V
C
E
S
D
S
L
Site 52
S629
L
Y
V
C
E
S
D
S
L
K
D
F
V
T
Q
Site 53
T635
D
S
L
K
D
F
V
T
Q
Q
T
T
C
Q
A
Site 54
T689
T
H
P
K
A
K
G
T
G
S
E
N
L
H
H
Site 55
S691
P
K
A
K
G
T
G
S
E
N
L
H
H
G
I
Site 56
S720
V
N
G
L
P
P
P
S
A
Q
F
P
R
K
T
Site 57
T727
S
A
Q
F
P
R
K
T
I
T
S
G
I
H
C
Site 58
S730
F
P
R
K
T
I
T
S
G
I
H
C
A
L
E
Site 59
S755
R
I
K
E
N
P
P
S
N
M
S
P
D
T
L
Site 60
S758
E
N
P
P
S
N
M
S
P
D
T
L
A
L
F
Site 61
T761
P
S
N
M
S
P
D
T
L
A
L
F
S
E
T
Site 62
Y770
A
L
F
S
E
T
A
Y
E
E
A
T
C
A
Q
Site 63
T787
P
G
V
C
E
T
K
T
N
L
T
T
E
Q
I
Site 64
Y797
T
T
E
Q
I
A
N
Y
V
A
R
K
C
H
S
Site 65
Y828
R
G
E
D
R
G
R
Y
R
L
A
L
L
K
A
Site 66
T841
K
A
M
E
L
I
E
T
H
R
P
S
E
V
V
Site 67
S845
L
I
E
T
H
R
P
S
E
V
V
F
S
P
A
Site 68
S850
R
P
S
E
V
V
F
S
P
A
T
G
V
W
G
Site 69
S880
R
T
V
V
F
G
L
S
P
E
C
D
Q
S
E
Site 70
S886
L
S
P
E
C
D
Q
S
E
E
F
H
K
L
C
Site 71
Y903
S
R
A
I
K
H
L
Y
L
L
Y
E
K
R
A
Site 72
Y906
I
K
H
L
Y
L
L
Y
E
K
R
A
A
Y
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation