PhosphoNET

           
Protein Info 
   
Short Name:  C4B
Full Name:  Complement C4-B
Alias:  Basic complement C4;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
Type: 
Mass (Da):  192793
Number AA:  1744
UniProt ID:  P0C0L5
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T15IWASSFFTLSLQKPR
Site 2S55RGQVVKGSVFLRNPS
Site 3S62SVFLRNPSRNNVPCS
Site 4S69SRNNVPCSPKVDFTL
Site 5T75CSPKVDFTLSSERDF
Site 6S77PKVDFTLSSERDFAL
Site 7S78KVDFTLSSERDFALL
Site 8S86ERDFALLSLQVPLKD
Site 9S114EVQLVAHSPWLKDSL
Site 10S120HSPWLKDSLSRTTNI
Site 11S122PWLKDSLSRTTNIQG
Site 12T124LKDSLSRTTNIQGIN
Site 13T125KDSLSRTTNIQGINL
Site 14S135QGINLLFSSRRGHLF
Site 15T145RGHLFLQTDQPIYNP
Site 16Y150LQTDQPIYNPGQRVR
Site 17Y158NPGQRVRYRVFALDQ
Site 18S170LDQKMRPSTDTITVM
Site 19T171DQKMRPSTDTITVMV
Site 20T173KMRPSTDTITVMVEN
Site 21T175RPSTDTITVMVENSH
Site 22Y192RVRKKEVYMPSSIFQ
Site 23S196KEVYMPSSIFQDDFV
Site 24S208DFVIPDISEPGTWKI
Site 25T212PDISEPGTWKISARF
Site 26S216EPGTWKISARFSDGL
Site 27S220WKISARFSDGLESNS
Site 28S225RFSDGLESNSSTQFE
Site 29S227SDGLESNSSTQFEVK
Site 30S228DGLESNSSTQFEVKK
Site 31T229GLESNSSTQFEVKKY
Site 32Y236TQFEVKKYVLPNFEV
Site 33T246PNFEVKITPGKPYIL
Site 34Y251KITPGKPYILTVPGH
Site 35T254PGKPYILTVPGHLDE
Site 36Y270QLDIQARYIYGKPVQ
Site 37Y272DIQARYIYGKPVQGV
Site 38T294LDEDGKKTFFRGLES
Site 39S301TFFRGLESQTKLVNG
Site 40S310TKLVNGQSHISLSKA
Site 41S313VNGQSHISLSKAEFQ
Site 42S315GQSHISLSKAEFQDA
Site 43T358EMEEAELTSWYFVSS
Site 44S359MEEAELTSWYFVSSP
Site 45Y361EAELTSWYFVSSPFS
Site 46S368YFVSSPFSLDLSKTK
Site 47S372SPFSLDLSKTKRHLV
Site 48T374FSLDLSKTKRHLVPG
Site 49S394QALVREMSGSPASGI
Site 50S399EMSGSPASGIPVKVS
Site 51S410VKVSATVSSPGSVPE
Site 52S411KVSATVSSPGSVPEV
Site 53S414ATVSSPGSVPEVQDI
Site 54S428IQQNTDGSGQVSIPI
Site 55S447TISELQLSVSAGSPH
Site 56S449SELQLSVSAGSPHPA
Site 57S452QLSVSAGSPHPAIAR
Site 58S474SGGPGFLSIERPDSR
Site 59S480LSIERPDSRPPRVGD
Site 60T488RPPRVGDTLNLNLRA
Site 61T501RAVGSGATFSHYYYM
Site 62Y505SGATFSHYYYMILSR
Site 63Y506GATFSHYYYMILSRG
Site 64Y507ATFSHYYYMILSRGQ
Site 65T525MNREPKRTLTSVSVF
Site 66T527REPKRTLTSVSVFVD
Site 67S528EPKRTLTSVSVFVDH
Site 68S530KRTLTSVSVFVDHHL
Site 69S557GDHPVANSLRVDVQA
Site 70S574CEGKLELSVDGAKQY
Site 71Y581SVDGAKQYRNGESVK
Site 72Y609GALDTALYAAGSKSH
Site 73S613TALYAAGSKSHKPLN
Site 74S615LYAAGSKSHKPLNMG
Site 75S630KVFEAMNSYDLGCGP
Site 76T661FSDGDQWTLSRKRLS
Site 77S663DGDQWTLSRKRLSCP
Site 78S668TLSRKRLSCPKEKTT
Site 79T674LSCPKEKTTRKKRNV
Site 80Y694INEKLGQYASPTAKR
Site 81S696EKLGQYASPTAKRCC
Site 82S715TRLPMMRSCEQRAAR
Site 83S741SCCQFAESLRKKSRD
Site 84S746AESLRKKSRDKGQAG
Site 85S776EDDIPVRSFFPENWL
Site 86S812TWEIHGLSLSKTKGL
Site 87S842LHLRLPMSVRRFEQL
Site 88Y856LELRPVLYNYLDKNL
Site 89Y858LRPVLYNYLDKNLTV
Site 90T864NYLDKNLTVSVHVSP
Site 91Y946IHREELVYELNPLDH
Site 92T957PLDHRGRTLEIPGNS
Site 93S976IPDGDFNSYVRVTAS
Site 94Y977PDGDFNSYVRVTASD
Site 95T981FNSYVRVTASDPLDT
Site 96T988TASDPLDTLGSEGAL
Site 97S991DPLDTLGSEGALSPG
Site 98Y1027PTLAASRYLDKTEQW
Site 99T1031ASRYLDKTEQWSTLP
Site 100T1036DKTEQWSTLPPETKD
Site 101Y1053VDLIQKGYMRIQQFR
Site 102S1065QFRKADGSYAAWLSR
Site 103Y1066FRKADGSYAAWLSRD
Site 104S1071GSYAAWLSRDSSTWL
Site 105S1074AAWLSRDSSTWLTAF
Site 106S1096AQEQVGGSPEKLQET
Site 107S1109ETSNWLLSQQQADGS
Site 108S1116SQQQADGSFQDLSPV
Site 109S1121DGSFQDLSPVIHRSM
Site 110S1171LKQRVEASISKANSF
Site 111S1173QRVEASISKANSFLG
Site 112S1177ASISKANSFLGEKAS
Site 113Y1229QETGDNLYWGSVTGS
Site 114S1232GDNLYWGSVTGSQSN
Site 115T1234NLYWGSVTGSQSNAV
Site 116S1236YWGSVTGSQSNAVSP
Site 117S1238GSVTGSQSNAVSPTP
Site 118S1242GSQSNAVSPTPAPRN
Site 119T1244QSNAVSPTPAPRNPS
Site 120S1251TPAPRNPSDPMPQAP
Site 121S1286AEMADQASAWLTRQG
Site 122T1290DQASAWLTRQGSFQG
Site 123S1294AWLTRQGSFQGGFRS
Site 124S1301SFQGGFRSTQDTVIA
Site 125T1330EERGLNVTLSSTGRN
Site 126S1332RGLNVTLSSTGRNGF
Site 127S1333GLNVTLSSTGRNGFK
Site 128T1334LNVTLSSTGRNGFKS
Site 129S1341TGRNGFKSHALQLNN
Site 130S1361LEEELQFSLGSKINV
Site 131T1377VGGNSKGTLKVLRTY
Site 132T1383GTLKVLRTYNVLDMK
Site 133Y1384TLKVLRTYNVLDMKN
Site 134T1402QDLQIEVTVKGHVEY
Site 135Y1417TMEANEDYEDYEYDE
Site 136Y1420ANEDYEDYEYDELPA
Site 137Y1422EDYEDYEYDELPAKD
Site 138T1439DAPLQPVTPLQLFEG
Site 139Y1468EQESRVHYTVCIWRN
Site 140S1506ADLEKLTSLSDRYVS
Site 141S1508LEKLTSLSDRYVSHF
Site 142Y1511LTSLSDRYVSHFETE
Site 143S1513SLSDRYVSHFETEGP
Site 144T1517RYVSHFETEGPHVLL
Site 145Y1525EGPHVLLYFDSVPTS
Site 146S1528HVLLYFDSVPTSREC
Site 147S1532YFDSVPTSRECVGFE
Site 148Y1557QPASATLYDYYNPER
Site 149Y1559ASATLYDYYNPERRC
Site 150Y1560SATLYDYYNPERRCS
Site 151S1567YNPERRCSVFYGAPS
Site 152Y1570ERRCSVFYGAPSKSR
Site 153Y1612GLQDEDGYRMKFACY
Site 154Y1619YRMKFACYYPRVEYG
Site 155Y1620RMKFACYYPRVEYGF
Site 156Y1625CYYPRVEYGFQVKVL
Site 157S1636VKVLREDSRAAFRLF
Site 158T1648RLFETKITQVLHFTK
Site 159S1672RNFLVRASCRLRLEP
Site 160Y1683RLEPGKEYLIMGLDG
Site 161T1692IMGLDGATYDLEGHP
Site 162Y1693MGLDGATYDLEGHPQ
Site 163Y1701DLEGHPQYLLDSNSW
Site 164S1707QYLLDSNSWIEEMPS
Site 165S1714SWIEEMPSERLCRST
Site 166S1720PSERLCRSTRQRAAC
Site 167T1721SERLCRSTRQRAACA
Site 168Y1737LNDFLQEYGTQGCQV
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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