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Updated November 2019
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Protein Info
Short Name:
C4A
Full Name:
Complement C4-A
Alias:
Acidic complement C4;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
Type:
Mass (Da):
192771
Number AA:
1744
UniProt ID:
P0C0L4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
I
W
A
S
S
F
F
T
L
S
L
Q
K
P
R
Site 2
S55
R
G
Q
V
V
K
G
S
V
F
L
R
N
P
S
Site 3
S62
S
V
F
L
R
N
P
S
R
N
N
V
P
C
S
Site 4
S69
S
R
N
N
V
P
C
S
P
K
V
D
F
T
L
Site 5
T75
C
S
P
K
V
D
F
T
L
S
S
E
R
D
F
Site 6
S77
P
K
V
D
F
T
L
S
S
E
R
D
F
A
L
Site 7
S78
K
V
D
F
T
L
S
S
E
R
D
F
A
L
L
Site 8
S86
E
R
D
F
A
L
L
S
L
Q
V
P
L
K
D
Site 9
S114
E
V
Q
L
V
A
H
S
P
W
L
K
D
S
L
Site 10
S120
H
S
P
W
L
K
D
S
L
S
R
T
T
N
I
Site 11
S122
P
W
L
K
D
S
L
S
R
T
T
N
I
Q
G
Site 12
T124
L
K
D
S
L
S
R
T
T
N
I
Q
G
I
N
Site 13
T125
K
D
S
L
S
R
T
T
N
I
Q
G
I
N
L
Site 14
S135
Q
G
I
N
L
L
F
S
S
R
R
G
H
L
F
Site 15
T145
R
G
H
L
F
L
Q
T
D
Q
P
I
Y
N
P
Site 16
Y150
L
Q
T
D
Q
P
I
Y
N
P
G
Q
R
V
R
Site 17
Y158
N
P
G
Q
R
V
R
Y
R
V
F
A
L
D
Q
Site 18
S170
L
D
Q
K
M
R
P
S
T
D
T
I
T
V
M
Site 19
T171
D
Q
K
M
R
P
S
T
D
T
I
T
V
M
V
Site 20
T173
K
M
R
P
S
T
D
T
I
T
V
M
V
E
N
Site 21
T175
R
P
S
T
D
T
I
T
V
M
V
E
N
S
H
Site 22
Y192
R
V
R
K
K
E
V
Y
M
P
S
S
I
F
Q
Site 23
S196
K
E
V
Y
M
P
S
S
I
F
Q
D
D
F
V
Site 24
S208
D
F
V
I
P
D
I
S
E
P
G
T
W
K
I
Site 25
T212
P
D
I
S
E
P
G
T
W
K
I
S
A
R
F
Site 26
S216
E
P
G
T
W
K
I
S
A
R
F
S
D
G
L
Site 27
S220
W
K
I
S
A
R
F
S
D
G
L
E
S
N
S
Site 28
S225
R
F
S
D
G
L
E
S
N
S
S
T
Q
F
E
Site 29
S227
S
D
G
L
E
S
N
S
S
T
Q
F
E
V
K
Site 30
S228
D
G
L
E
S
N
S
S
T
Q
F
E
V
K
K
Site 31
T229
G
L
E
S
N
S
S
T
Q
F
E
V
K
K
Y
Site 32
Y236
T
Q
F
E
V
K
K
Y
V
L
P
N
F
E
V
Site 33
T246
P
N
F
E
V
K
I
T
P
G
K
P
Y
I
L
Site 34
Y251
K
I
T
P
G
K
P
Y
I
L
T
V
P
G
H
Site 35
T254
P
G
K
P
Y
I
L
T
V
P
G
H
L
D
E
Site 36
Y270
Q
L
D
I
Q
A
R
Y
I
Y
G
K
P
V
Q
Site 37
Y272
D
I
Q
A
R
Y
I
Y
G
K
P
V
Q
G
V
Site 38
T294
L
D
E
D
G
K
K
T
F
F
R
G
L
E
S
Site 39
S301
T
F
F
R
G
L
E
S
Q
T
K
L
V
N
G
Site 40
S310
T
K
L
V
N
G
Q
S
H
I
S
L
S
K
A
Site 41
S313
V
N
G
Q
S
H
I
S
L
S
K
A
E
F
Q
Site 42
S315
G
Q
S
H
I
S
L
S
K
A
E
F
Q
D
A
Site 43
T358
E
M
E
E
A
E
L
T
S
W
Y
F
V
S
S
Site 44
S359
M
E
E
A
E
L
T
S
W
Y
F
V
S
S
P
Site 45
Y361
E
A
E
L
T
S
W
Y
F
V
S
S
P
F
S
Site 46
S368
Y
F
V
S
S
P
F
S
L
D
L
S
K
T
K
Site 47
S372
S
P
F
S
L
D
L
S
K
T
K
R
H
L
V
Site 48
T374
F
S
L
D
L
S
K
T
K
R
H
L
V
P
G
Site 49
S394
Q
A
L
V
R
E
M
S
G
S
P
A
S
G
I
Site 50
S399
E
M
S
G
S
P
A
S
G
I
P
V
K
V
S
Site 51
S410
V
K
V
S
A
T
V
S
S
P
G
S
V
P
E
Site 52
S411
K
V
S
A
T
V
S
S
P
G
S
V
P
E
V
Site 53
S414
A
T
V
S
S
P
G
S
V
P
E
V
Q
D
I
Site 54
S428
I
Q
Q
N
T
D
G
S
G
Q
V
S
I
P
I
Site 55
S447
T
I
S
E
L
Q
L
S
V
S
A
G
S
P
H
Site 56
S449
S
E
L
Q
L
S
V
S
A
G
S
P
H
P
A
Site 57
S452
Q
L
S
V
S
A
G
S
P
H
P
A
I
A
R
Site 58
S474
S
G
G
P
G
F
L
S
I
E
R
P
D
S
R
Site 59
S480
L
S
I
E
R
P
D
S
R
P
P
R
V
G
D
Site 60
T488
R
P
P
R
V
G
D
T
L
N
L
N
L
R
A
Site 61
T501
R
A
V
G
S
G
A
T
F
S
H
Y
Y
Y
M
Site 62
Y505
S
G
A
T
F
S
H
Y
Y
Y
M
I
L
S
R
Site 63
Y506
G
A
T
F
S
H
Y
Y
Y
M
I
L
S
R
G
Site 64
Y507
A
T
F
S
H
Y
Y
Y
M
I
L
S
R
G
Q
Site 65
T525
M
N
R
E
P
K
R
T
L
T
S
V
S
V
F
Site 66
T527
R
E
P
K
R
T
L
T
S
V
S
V
F
V
D
Site 67
S528
E
P
K
R
T
L
T
S
V
S
V
F
V
D
H
Site 68
S530
K
R
T
L
T
S
V
S
V
F
V
D
H
H
L
Site 69
S557
G
D
H
P
V
A
N
S
L
R
V
D
V
Q
A
Site 70
S574
C
E
G
K
L
E
L
S
V
D
G
A
K
Q
Y
Site 71
Y581
S
V
D
G
A
K
Q
Y
R
N
G
E
S
V
K
Site 72
Y609
G
A
L
D
T
A
L
Y
A
A
G
S
K
S
H
Site 73
S613
T
A
L
Y
A
A
G
S
K
S
H
K
P
L
N
Site 74
S615
L
Y
A
A
G
S
K
S
H
K
P
L
N
M
G
Site 75
S630
K
V
F
E
A
M
N
S
Y
D
L
G
C
G
P
Site 76
T661
F
S
D
G
D
Q
W
T
L
S
R
K
R
L
S
Site 77
S663
D
G
D
Q
W
T
L
S
R
K
R
L
S
C
P
Site 78
S668
T
L
S
R
K
R
L
S
C
P
K
E
K
T
T
Site 79
T674
L
S
C
P
K
E
K
T
T
R
K
K
R
N
V
Site 80
Y694
I
N
E
K
L
G
Q
Y
A
S
P
T
A
K
R
Site 81
S696
E
K
L
G
Q
Y
A
S
P
T
A
K
R
C
C
Site 82
S715
T
R
L
P
M
M
R
S
C
E
Q
R
A
A
R
Site 83
S741
S
C
C
Q
F
A
E
S
L
R
K
K
S
R
D
Site 84
S746
A
E
S
L
R
K
K
S
R
D
K
G
Q
A
G
Site 85
S776
E
D
D
I
P
V
R
S
F
F
P
E
N
W
L
Site 86
S812
T
W
E
I
H
G
L
S
L
S
K
T
K
G
L
Site 87
S842
L
H
L
R
L
P
M
S
V
R
R
F
E
Q
L
Site 88
Y856
L
E
L
R
P
V
L
Y
N
Y
L
D
K
N
L
Site 89
Y858
L
R
P
V
L
Y
N
Y
L
D
K
N
L
T
V
Site 90
T864
N
Y
L
D
K
N
L
T
V
S
V
H
V
S
P
Site 91
Y946
I
H
R
E
E
L
V
Y
E
L
N
P
L
D
H
Site 92
T957
P
L
D
H
R
G
R
T
L
E
I
P
G
N
S
Site 93
S976
I
P
D
G
D
F
N
S
Y
V
R
V
T
A
S
Site 94
Y977
P
D
G
D
F
N
S
Y
V
R
V
T
A
S
D
Site 95
T981
F
N
S
Y
V
R
V
T
A
S
D
P
L
D
T
Site 96
T988
T
A
S
D
P
L
D
T
L
G
S
E
G
A
L
Site 97
S991
D
P
L
D
T
L
G
S
E
G
A
L
S
P
G
Site 98
Y1027
P
T
L
A
A
S
R
Y
L
D
K
T
E
Q
W
Site 99
T1031
A
S
R
Y
L
D
K
T
E
Q
W
S
T
L
P
Site 100
T1036
D
K
T
E
Q
W
S
T
L
P
P
E
T
K
D
Site 101
Y1053
V
D
L
I
Q
K
G
Y
M
R
I
Q
Q
F
R
Site 102
S1065
Q
F
R
K
A
D
G
S
Y
A
A
W
L
S
R
Site 103
Y1066
F
R
K
A
D
G
S
Y
A
A
W
L
S
R
D
Site 104
S1071
G
S
Y
A
A
W
L
S
R
D
S
S
T
W
L
Site 105
S1074
A
A
W
L
S
R
D
S
S
T
W
L
T
A
F
Site 106
S1096
A
Q
E
Q
V
G
G
S
P
E
K
L
Q
E
T
Site 107
S1109
E
T
S
N
W
L
L
S
Q
Q
Q
A
D
G
S
Site 108
S1116
S
Q
Q
Q
A
D
G
S
F
Q
D
P
C
P
V
Site 109
S1171
L
K
Q
R
V
E
A
S
I
S
K
A
N
S
F
Site 110
S1173
Q
R
V
E
A
S
I
S
K
A
N
S
F
L
G
Site 111
S1177
A
S
I
S
K
A
N
S
F
L
G
E
K
A
S
Site 112
Y1229
Q
E
T
G
D
N
L
Y
W
G
S
V
T
G
S
Site 113
S1232
G
D
N
L
Y
W
G
S
V
T
G
S
Q
S
N
Site 114
T1234
N
L
Y
W
G
S
V
T
G
S
Q
S
N
A
V
Site 115
S1236
Y
W
G
S
V
T
G
S
Q
S
N
A
V
S
P
Site 116
S1238
G
S
V
T
G
S
Q
S
N
A
V
S
P
T
P
Site 117
S1242
G
S
Q
S
N
A
V
S
P
T
P
A
P
R
N
Site 118
T1244
Q
S
N
A
V
S
P
T
P
A
P
R
N
P
S
Site 119
S1251
T
P
A
P
R
N
P
S
D
P
M
P
Q
A
P
Site 120
S1286
A
E
M
A
D
Q
A
S
A
W
L
T
R
Q
G
Site 121
T1290
D
Q
A
S
A
W
L
T
R
Q
G
S
F
Q
G
Site 122
S1294
A
W
L
T
R
Q
G
S
F
Q
G
G
F
R
S
Site 123
S1301
S
F
Q
G
G
F
R
S
T
Q
D
T
V
I
A
Site 124
T1330
E
E
R
G
L
N
V
T
L
S
S
T
G
R
N
Site 125
S1332
R
G
L
N
V
T
L
S
S
T
G
R
N
G
F
Site 126
S1333
G
L
N
V
T
L
S
S
T
G
R
N
G
F
K
Site 127
T1334
L
N
V
T
L
S
S
T
G
R
N
G
F
K
S
Site 128
S1341
T
G
R
N
G
F
K
S
H
A
L
Q
L
N
N
Site 129
S1361
L
E
E
E
L
Q
F
S
L
G
S
K
I
N
V
Site 130
T1377
V
G
G
N
S
K
G
T
L
K
V
L
R
T
Y
Site 131
T1383
G
T
L
K
V
L
R
T
Y
N
V
L
D
M
K
Site 132
Y1384
T
L
K
V
L
R
T
Y
N
V
L
D
M
K
N
Site 133
T1402
Q
D
L
Q
I
E
V
T
V
K
G
H
V
E
Y
Site 134
Y1417
T
M
E
A
N
E
D
Y
E
D
Y
E
Y
D
E
Site 135
Y1420
A
N
E
D
Y
E
D
Y
E
Y
D
E
L
P
A
Site 136
Y1422
E
D
Y
E
D
Y
E
Y
D
E
L
P
A
K
D
Site 137
T1439
D
A
P
L
Q
P
V
T
P
L
Q
L
F
E
G
Site 138
Y1468
E
Q
E
S
R
V
H
Y
T
V
C
I
W
R
N
Site 139
S1492
I
A
D
V
T
L
L
S
G
F
H
A
L
R
A
Site 140
S1506
A
D
L
E
K
L
T
S
L
S
D
R
Y
V
S
Site 141
S1508
L
E
K
L
T
S
L
S
D
R
Y
V
S
H
F
Site 142
Y1511
L
T
S
L
S
D
R
Y
V
S
H
F
E
T
E
Site 143
S1513
S
L
S
D
R
Y
V
S
H
F
E
T
E
G
P
Site 144
T1517
R
Y
V
S
H
F
E
T
E
G
P
H
V
L
L
Site 145
Y1525
E
G
P
H
V
L
L
Y
F
D
S
V
P
T
S
Site 146
S1528
H
V
L
L
Y
F
D
S
V
P
T
S
R
E
C
Site 147
S1532
Y
F
D
S
V
P
T
S
R
E
C
V
G
F
E
Site 148
Y1557
Q
P
A
S
A
T
L
Y
D
Y
Y
N
P
E
R
Site 149
Y1559
A
S
A
T
L
Y
D
Y
Y
N
P
E
R
R
C
Site 150
Y1560
S
A
T
L
Y
D
Y
Y
N
P
E
R
R
C
S
Site 151
S1567
Y
N
P
E
R
R
C
S
V
F
Y
G
A
P
S
Site 152
Y1570
E
R
R
C
S
V
F
Y
G
A
P
S
K
S
R
Site 153
Y1612
G
L
Q
D
E
D
G
Y
R
M
K
F
A
C
Y
Site 154
Y1619
Y
R
M
K
F
A
C
Y
Y
P
R
V
E
Y
G
Site 155
Y1620
R
M
K
F
A
C
Y
Y
P
R
V
E
Y
G
F
Site 156
Y1625
C
Y
Y
P
R
V
E
Y
G
F
Q
V
K
V
L
Site 157
S1636
V
K
V
L
R
E
D
S
R
A
A
F
R
L
F
Site 158
T1648
R
L
F
E
T
K
I
T
Q
V
L
H
F
T
K
Site 159
S1672
R
N
F
L
V
R
A
S
C
R
L
R
L
E
P
Site 160
Y1683
R
L
E
P
G
K
E
Y
L
I
M
G
L
D
G
Site 161
T1692
I
M
G
L
D
G
A
T
Y
D
L
E
G
H
P
Site 162
Y1693
M
G
L
D
G
A
T
Y
D
L
E
G
H
P
Q
Site 163
Y1701
D
L
E
G
H
P
Q
Y
L
L
D
S
N
S
W
Site 164
S1707
Q
Y
L
L
D
S
N
S
W
I
E
E
M
P
S
Site 165
S1714
S
W
I
E
E
M
P
S
E
R
L
C
R
S
T
Site 166
S1720
P
S
E
R
L
C
R
S
T
R
Q
R
A
A
C
Site 167
T1721
S
E
R
L
C
R
S
T
R
Q
R
A
A
C
A
Site 168
Y1737
L
N
D
F
L
Q
E
Y
G
T
Q
G
C
Q
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation