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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FURIN
Full Name:
Furin
Alias:
Dibasic-processing enzyme; FUR; Furin (paired basic amino acid cleaving enzyme); PACE; Paired basic amino acid residue cleaving enzyme; PCSK3; SPC1
Type:
Protease; Membrane protein, integral; Vesicle protein; Cell surface; EC 3.4.21.75
Mass (Da):
86659
Number AA:
794
UniProt ID:
P09958
International Prot ID:
IPI00018387
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
GO:0009986
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0048406
GO:0042277
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0032804
GO:0032911
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
G
G
P
A
V
A
N
S
V
A
R
K
H
G
F
Site 2
T73
H
F
W
H
R
G
V
T
K
R
S
L
S
P
H
Site 3
S76
H
R
G
V
T
K
R
S
L
S
P
H
R
P
R
Site 4
S78
G
V
T
K
R
S
L
S
P
H
R
P
R
H
S
Site 5
S85
S
P
H
R
P
R
H
S
R
L
Q
R
E
P
Q
Site 6
T105
Q
Q
V
A
K
R
R
T
K
R
D
V
Y
Q
E
Site 7
Y110
R
R
T
K
R
D
V
Y
Q
E
P
T
D
P
K
Site 8
T114
R
D
V
Y
Q
E
P
T
D
P
K
F
P
Q
Q
Site 9
Y123
P
K
F
P
Q
Q
W
Y
L
S
G
V
T
Q
R
Site 10
Y167
H
P
D
L
A
G
N
Y
D
P
G
A
S
F
D
Site 11
S172
G
N
Y
D
P
G
A
S
F
D
V
N
D
Q
D
Site 12
Y186
D
P
D
P
Q
P
R
Y
T
Q
M
N
D
N
R
Site 13
T196
M
N
D
N
R
H
G
T
R
C
A
G
E
V
A
Site 14
Y250
N
P
N
H
I
H
I
Y
S
A
S
W
G
P
E
Site 15
T262
G
P
E
D
D
G
K
T
V
D
G
P
A
R
L
Site 16
S279
E
A
F
F
R
G
V
S
Q
G
R
G
G
L
G
Site 17
S293
G
S
I
F
V
W
A
S
G
N
G
G
R
E
H
Site 18
Y308
D
S
C
N
C
D
G
Y
T
N
S
I
Y
T
L
Site 19
Y313
D
G
Y
T
N
S
I
Y
T
L
S
I
S
S
A
Site 20
T314
G
Y
T
N
S
I
Y
T
L
S
I
S
S
A
T
Site 21
Y329
Q
F
G
N
V
P
W
Y
S
E
A
C
S
S
T
Site 22
S330
F
G
N
V
P
W
Y
S
E
A
C
S
S
T
L
Site 23
S334
P
W
Y
S
E
A
C
S
S
T
L
A
T
T
Y
Site 24
S335
W
Y
S
E
A
C
S
S
T
L
A
T
T
Y
S
Site 25
T336
Y
S
E
A
C
S
S
T
L
A
T
T
Y
S
S
Site 26
T339
A
C
S
S
T
L
A
T
T
Y
S
S
G
N
Q
Site 27
S342
S
T
L
A
T
T
Y
S
S
G
N
Q
N
E
K
Site 28
T361
T
D
L
R
Q
K
C
T
E
S
H
T
G
T
S
Site 29
S363
L
R
Q
K
C
T
E
S
H
T
G
T
S
A
S
Site 30
T367
C
T
E
S
H
T
G
T
S
A
S
A
P
L
A
Site 31
S401
Q
H
L
V
V
Q
T
S
K
P
A
H
L
N
A
Site 32
S421
N
G
V
G
R
K
V
S
H
S
Y
G
Y
G
L
Site 33
S423
V
G
R
K
V
S
H
S
Y
G
Y
G
L
L
D
Site 34
T443
A
L
A
Q
N
W
T
T
V
A
P
Q
R
K
C
Site 35
T456
K
C
I
I
D
I
L
T
E
P
K
D
I
G
K
Site 36
T470
K
R
L
E
V
R
K
T
V
T
A
C
L
G
E
Site 37
T492
E
H
A
Q
A
R
L
T
L
S
Y
N
R
R
G
Site 38
S494
A
Q
A
R
L
T
L
S
Y
N
R
R
G
D
L
Site 39
Y495
Q
A
R
L
T
L
S
Y
N
R
R
G
D
L
A
Site 40
T514
S
P
M
G
T
R
S
T
L
L
A
A
R
P
H
Site 41
Y523
L
A
A
R
P
H
D
Y
S
A
D
G
F
N
D
Site 42
S544
H
S
W
D
E
D
P
S
G
E
W
V
L
E
I
Site 43
T554
W
V
L
E
I
E
N
T
S
E
A
N
N
Y
G
Site 44
Y560
N
T
S
E
A
N
N
Y
G
T
L
T
K
F
T
Site 45
S584
G
L
P
V
P
P
E
S
S
G
C
K
T
L
T
Site 46
S585
L
P
V
P
P
E
S
S
G
C
K
T
L
T
S
Site 47
T589
P
E
S
S
G
C
K
T
L
T
S
S
Q
A
C
Site 48
T625
F
A
P
Q
V
L
D
T
H
Y
S
T
E
N
D
Site 49
Y627
P
Q
V
L
D
T
H
Y
S
T
E
N
D
V
E
Site 50
S628
Q
V
L
D
T
H
Y
S
T
E
N
D
V
E
T
Site 51
T635
S
T
E
N
D
V
E
T
I
R
A
S
V
C
A
Site 52
S664
T
D
C
L
S
C
P
S
H
A
S
L
D
P
V
Site 53
S667
L
S
C
P
S
H
A
S
L
D
P
V
E
Q
T
Site 54
T674
S
L
D
P
V
E
Q
T
C
S
R
Q
S
Q
S
Site 55
S676
D
P
V
E
Q
T
C
S
R
Q
S
Q
S
S
R
Site 56
S679
E
Q
T
C
S
R
Q
S
Q
S
S
R
E
S
P
Site 57
S681
T
C
S
R
Q
S
Q
S
S
R
E
S
P
P
Q
Site 58
S682
C
S
R
Q
S
Q
S
S
R
E
S
P
P
Q
Q
Site 59
S685
Q
S
Q
S
S
R
E
S
P
P
Q
Q
Q
P
P
Site 60
S743
L
Q
L
R
S
G
F
S
F
R
G
V
K
V
Y
Site 61
S758
T
M
D
R
G
L
I
S
Y
K
G
L
P
P
E
Site 62
Y759
M
D
R
G
L
I
S
Y
K
G
L
P
P
E
A
Site 63
S773
A
W
Q
E
E
C
P
S
D
S
E
E
D
E
G
Site 64
S775
Q
E
E
C
P
S
D
S
E
E
D
E
G
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation