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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLA
Full Name:
DNA polymerase alpha catalytic subunit
Alias:
DNA pol alpha; DPOA; DPOLA; p180; polymerase (DNA directed) alpha 1, catalytic subunit
Type:
Nuclear envelope; Nucleotide Metabolism - pyrimidine; DNA replication; EC 2.7.7.7; DNA repair; Nucleotide Metabolism - purine; Transferase
Mass (Da):
165913
Number AA:
1462
UniProt ID:
P09884
International Prot ID:
IPI00220317
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005658
GO:0005737
GO:0005635
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003887
GO:0003682
PhosphoSite+
KinaseNET
Biological Process:
GO:0006270
GO:0000731
GO:0000084
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
P
V
H
G
D
D
S
L
S
D
S
G
S
F
Site 2
S11
V
H
G
D
D
S
L
S
D
S
G
S
F
V
S
Site 3
S13
G
D
D
S
L
S
D
S
G
S
F
V
S
S
R
Site 4
S15
D
S
L
S
D
S
G
S
F
V
S
S
R
A
R
Site 5
S18
S
D
S
G
S
F
V
S
S
R
A
R
R
E
K
Site 6
S19
D
S
G
S
F
V
S
S
R
A
R
R
E
K
K
Site 7
S27
R
A
R
R
E
K
K
S
K
K
G
R
Q
E
A
Site 8
Y49
K
A
G
E
K
Y
K
Y
E
V
E
D
F
T
G
Site 9
T55
K
Y
E
V
E
D
F
T
G
V
Y
E
E
V
D
Site 10
Y58
V
E
D
F
T
G
V
Y
E
E
V
D
E
E
Q
Site 11
Y66
E
E
V
D
E
E
Q
Y
S
K
L
V
Q
A
R
Site 12
Y87
V
D
D
D
G
I
G
Y
V
E
D
G
R
E
I
Site 13
T168
D
I
L
Q
D
L
N
T
E
T
P
Q
I
T
P
Site 14
T170
L
Q
D
L
N
T
E
T
P
Q
I
T
P
P
P
Site 15
T174
N
T
E
T
P
Q
I
T
P
P
P
V
M
I
L
Site 16
S186
M
I
L
K
K
K
R
S
I
G
A
S
P
N
P
Site 17
S190
K
K
R
S
I
G
A
S
P
N
P
F
S
V
H
Site 18
T198
P
N
P
F
S
V
H
T
A
T
A
V
P
S
G
Site 19
T200
P
F
S
V
H
T
A
T
A
V
P
S
G
K
I
Site 20
S209
V
P
S
G
K
I
A
S
P
V
S
R
K
E
P
Site 21
S212
G
K
I
A
S
P
V
S
R
K
E
P
P
L
T
Site 22
T219
S
R
K
E
P
P
L
T
P
V
P
L
K
R
A
Site 23
T238
D
D
V
Q
V
E
S
T
E
E
E
Q
E
S
G
Site 24
S244
S
T
E
E
E
Q
E
S
G
A
M
E
F
E
D
Site 25
S277
A
K
A
W
D
K
E
S
E
P
A
E
E
V
K
Site 26
S289
E
V
K
Q
E
A
D
S
G
K
G
T
V
S
Y
Site 27
T293
E
A
D
S
G
K
G
T
V
S
Y
L
G
S
F
Site 28
S295
D
S
G
K
G
T
V
S
Y
L
G
S
F
L
P
Site 29
Y296
S
G
K
G
T
V
S
Y
L
G
S
F
L
P
D
Site 30
S315
D
I
D
Q
E
G
D
S
S
F
S
V
Q
E
V
Site 31
S316
I
D
Q
E
G
D
S
S
F
S
V
Q
E
V
Q
Site 32
S318
Q
E
G
D
S
S
F
S
V
Q
E
V
Q
V
D
Site 33
S327
Q
E
V
Q
V
D
S
S
H
L
P
L
V
K
G
Site 34
Y353
L
D
A
Y
E
D
Q
Y
N
Q
P
G
V
V
F
Site 35
Y388
K
N
I
E
R
T
L
Y
F
L
P
R
E
M
K
Site 36
T406
N
T
G
K
E
T
G
T
P
I
S
M
K
D
V
Site 37
S409
K
E
T
G
T
P
I
S
M
K
D
V
Y
E
E
Site 38
Y414
P
I
S
M
K
D
V
Y
E
E
F
D
E
K
I
Site 39
T423
E
F
D
E
K
I
A
T
K
Y
K
I
M
K
F
Site 40
Y425
D
E
K
I
A
T
K
Y
K
I
M
K
F
K
S
Site 41
Y439
S
K
P
V
E
K
N
Y
A
F
E
I
P
D
V
Site 42
S450
I
P
D
V
P
E
K
S
E
Y
L
E
V
K
Y
Site 43
Y452
D
V
P
E
K
S
E
Y
L
E
V
K
Y
S
A
Site 44
Y457
S
E
Y
L
E
V
K
Y
S
A
E
M
P
Q
L
Site 45
S458
E
Y
L
E
V
K
Y
S
A
E
M
P
Q
L
P
Site 46
T472
P
Q
D
L
K
G
E
T
F
S
H
V
F
G
T
Site 47
S474
D
L
K
G
E
T
F
S
H
V
F
G
T
N
T
Site 48
T479
T
F
S
H
V
F
G
T
N
T
S
S
L
E
L
Site 49
S503
P
C
W
L
E
V
K
S
P
Q
L
L
N
Q
P
Site 50
S581
A
P
K
P
P
F
Q
S
H
F
C
V
V
S
K
Site 51
Y596
P
K
D
C
I
F
P
Y
A
F
K
E
V
I
E
Site 52
S668
K
I
G
R
L
K
R
S
N
M
P
K
L
G
G
Site 53
S705
K
E
L
I
R
C
K
S
Y
H
L
S
E
L
V
Site 54
S709
R
C
K
S
Y
H
L
S
E
L
V
Q
Q
I
L
Site 55
S733
E
N
I
Q
N
M
Y
S
E
S
S
Q
L
L
Y
Site 56
Y740
S
E
S
S
Q
L
L
Y
L
L
E
H
T
W
K
Site 57
S777
N
I
A
G
N
I
M
S
R
T
L
M
G
G
R
Site 58
T779
A
G
N
I
M
S
R
T
L
M
G
G
R
S
E
Site 59
S785
R
T
L
M
G
G
R
S
E
R
N
E
F
L
L
Site 60
Y801
H
A
F
Y
E
N
N
Y
I
V
P
D
K
Q
I
Site 61
T827
D
E
E
I
D
G
D
T
N
K
Y
K
K
G
R
Site 62
Y839
K
G
R
K
K
A
A
Y
A
G
G
L
V
L
D
Site 63
S884
T
T
V
Q
R
V
A
S
E
A
Q
K
V
T
E
Site 64
Y942
N
P
D
L
I
L
Q
Y
D
I
R
Q
K
A
L
Site 65
Y964
Y
G
C
L
G
F
S
Y
S
R
F
Y
A
K
P
Site 66
S1012
S
I
M
I
N
T
N
S
T
N
L
E
E
V
F
Site 67
S1027
K
L
G
N
K
V
K
S
E
V
N
K
L
Y
K
Site 68
Y1055
L
L
L
K
K
K
K
Y
A
A
L
V
V
E
P
Site 69
S1064
A
L
V
V
E
P
T
S
D
G
N
Y
V
T
K
Site 70
Y1068
E
P
T
S
D
G
N
Y
V
T
K
Q
E
L
K
Site 71
T1107
L
S
D
Q
S
R
D
T
I
V
E
N
I
Q
K
Site 72
S1127
G
E
N
V
L
N
G
S
V
P
V
S
Q
F
E
Site 73
S1131
L
N
G
S
V
P
V
S
Q
F
E
I
N
K
A
Site 74
T1140
F
E
I
N
K
A
L
T
K
D
P
Q
D
Y
P
Site 75
Y1146
L
T
K
D
P
Q
D
Y
P
D
K
K
S
L
P
Site 76
S1151
Q
D
Y
P
D
K
K
S
L
P
H
V
H
V
A
Site 77
T1174
R
K
V
K
A
G
D
T
V
S
Y
V
I
C
Q
Site 78
Y1177
K
A
G
D
T
V
S
Y
V
I
C
Q
D
G
S
Site 79
S1184
Y
V
I
C
Q
D
G
S
N
L
T
A
S
Q
R
Site 80
S1189
D
G
S
N
L
T
A
S
Q
R
A
Y
A
P
E
Site 81
Y1193
L
T
A
S
Q
R
A
Y
A
P
E
Q
L
Q
K
Site 82
T1205
L
Q
K
Q
D
N
L
T
I
D
T
Q
Y
Y
L
Site 83
Y1210
N
L
T
I
D
T
Q
Y
Y
L
A
Q
Q
I
H
Site 84
Y1211
L
T
I
D
T
Q
Y
Y
L
A
Q
Q
I
H
P
Site 85
T1268
L
G
G
P
A
Q
L
T
D
E
E
K
Y
R
D
Site 86
Y1292
T
C
G
T
E
N
I
Y
D
N
V
F
D
G
S
Site 87
S1306
S
G
T
D
M
E
P
S
L
Y
R
C
S
N
I
Site 88
Y1308
T
D
M
E
P
S
L
Y
R
C
S
N
I
D
C
Site 89
S1311
E
P
S
L
Y
R
C
S
N
I
D
C
K
A
S
Site 90
S1318
S
N
I
D
C
K
A
S
P
L
T
F
T
V
Q
Site 91
T1321
D
C
K
A
S
P
L
T
F
T
V
Q
L
S
N
Site 92
T1323
K
A
S
P
L
T
F
T
V
Q
L
S
N
K
L
Site 93
Y1341
I
R
R
F
I
K
K
Y
Y
D
G
W
L
I
C
Site 94
Y1342
R
R
F
I
K
K
Y
Y
D
G
W
L
I
C
E
Site 95
T1357
E
P
T
C
R
N
R
T
R
H
L
P
L
Q
F
Site 96
S1365
R
H
L
P
L
Q
F
S
R
T
G
P
L
C
P
Site 97
T1378
C
P
A
C
M
K
A
T
L
Q
P
E
Y
S
D
Site 98
Y1383
K
A
T
L
Q
P
E
Y
S
D
K
S
L
Y
T
Site 99
S1384
A
T
L
Q
P
E
Y
S
D
K
S
L
Y
T
Q
Site 100
S1387
Q
P
E
Y
S
D
K
S
L
Y
T
Q
L
C
F
Site 101
Y1389
E
Y
S
D
K
S
L
Y
T
Q
L
C
F
Y
R
Site 102
T1410
C
A
L
E
K
L
T
T
D
H
E
K
D
K
L
Site 103
T1423
K
L
K
K
Q
F
F
T
P
K
V
L
Q
D
Y
Site 104
Y1430
T
P
K
V
L
Q
D
Y
R
K
L
K
N
T
A
Site 105
T1436
D
Y
R
K
L
K
N
T
A
E
Q
F
L
S
R
Site 106
S1442
N
T
A
E
Q
F
L
S
R
S
G
Y
S
E
V
Site 107
Y1446
Q
F
L
S
R
S
G
Y
S
E
V
N
L
S
K
Site 108
S1447
F
L
S
R
S
G
Y
S
E
V
N
L
S
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation