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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANXA4
Full Name:
Annexin A4
Alias:
35-beta calcimedin; Annexin IV; ANX4; Carbohydrate-binding protein P33/P41; Chromobindin 4; Endonexin I; Lipocortin IV; P32.5; P33/41; PAP-II; Placental anticoagulant protein II; PP4-X; Protein II
Type:
Lipid binding protein; Calcium-binding protein
Mass (Da):
35752
Number AA:
318
UniProt ID:
P09525
International Prot ID:
IPI00872780
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005544
GO:0004859
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
G
G
T
V
K
A
A
S
G
F
N
A
M
E
D
Site 2
T22
N
A
M
E
D
A
Q
T
L
R
K
A
M
K
G
Site 3
Y43
A
I
I
S
V
L
A
Y
R
N
T
A
Q
R
Q
Site 4
T46
S
V
L
A
Y
R
N
T
A
Q
R
Q
E
I
R
Site 5
T54
A
Q
R
Q
E
I
R
T
A
Y
K
S
T
I
G
Site 6
Y56
R
Q
E
I
R
T
A
Y
K
S
T
I
G
R
D
Site 7
S58
E
I
R
T
A
Y
K
S
T
I
G
R
D
L
I
Site 8
S70
D
L
I
D
D
L
K
S
E
L
S
G
N
F
E
Site 9
S73
D
D
L
K
S
E
L
S
G
N
F
E
Q
V
I
Site 10
Y90
M
M
T
P
T
V
L
Y
D
V
Q
E
L
R
R
Site 11
T117
I
E
I
L
A
S
R
T
P
E
E
I
R
R
I
Site 12
S125
P
E
E
I
R
R
I
S
Q
T
Y
Q
Q
Q
Y
Site 13
T127
E
I
R
R
I
S
Q
T
Y
Q
Q
Q
Y
G
R
Site 14
Y128
I
R
R
I
S
Q
T
Y
Q
Q
Q
Y
G
R
S
Site 15
Y132
S
Q
T
Y
Q
Q
Q
Y
G
R
S
L
E
D
D
Site 16
S135
Y
Q
Q
Q
Y
G
R
S
L
E
D
D
I
R
S
Site 17
S142
S
L
E
D
D
I
R
S
D
T
S
F
M
F
Q
Site 18
T144
E
D
D
I
R
S
D
T
S
F
M
F
Q
R
V
Site 19
S145
D
D
I
R
S
D
T
S
F
M
F
Q
R
V
L
Site 20
S156
Q
R
V
L
V
S
L
S
A
G
G
R
D
E
G
Site 21
Y165
G
G
R
D
E
G
N
Y
L
D
D
A
L
V
R
Site 22
Y179
R
Q
D
A
Q
D
L
Y
E
A
G
E
K
K
W
Site 23
T188
A
G
E
K
K
W
G
T
D
E
V
K
F
L
T
Site 24
T195
T
D
E
V
K
F
L
T
V
L
C
S
R
N
R
Site 25
S199
K
F
L
T
V
L
C
S
R
N
R
N
H
L
L
Site 26
Y212
L
L
H
V
F
D
E
Y
K
R
I
S
Q
K
D
Site 27
S216
F
D
E
Y
K
R
I
S
Q
K
D
I
E
Q
S
Site 28
S223
S
Q
K
D
I
E
Q
S
I
K
S
E
T
S
G
Site 29
S226
D
I
E
Q
S
I
K
S
E
T
S
G
S
F
E
Site 30
S231
I
K
S
E
T
S
G
S
F
E
D
A
L
L
A
Site 31
S247
V
K
C
M
R
N
K
S
A
Y
F
A
E
K
L
Site 32
Y249
C
M
R
N
K
S
A
Y
F
A
E
K
L
Y
K
Site 33
Y255
A
Y
F
A
E
K
L
Y
K
S
M
K
G
L
G
Site 34
S257
F
A
E
K
L
Y
K
S
M
K
G
L
G
T
D
Site 35
T263
K
S
M
K
G
L
G
T
D
D
N
T
L
I
R
Site 36
Y291
R
A
H
F
K
R
L
Y
G
K
S
L
Y
S
F
Site 37
S294
F
K
R
L
Y
G
K
S
L
Y
S
F
I
K
G
Site 38
Y296
R
L
Y
G
K
S
L
Y
S
F
I
K
G
D
T
Site 39
S297
L
Y
G
K
S
L
Y
S
F
I
K
G
D
T
S
Site 40
S304
S
F
I
K
G
D
T
S
G
D
Y
R
K
V
L
Site 41
Y307
K
G
D
T
S
G
D
Y
R
K
V
L
L
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation