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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GNAO1
Full Name:
Guanine nucleotide-binding protein G(o) subunit alpha
Alias:
G-ALPHA-o; GNAO; Guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O; Guanine nucleotide binding protein, alpha activating activity polypeptide O; Guanine nucleotide binding protein, alpha activating polypeptide O; Guanine nucleotide-binding protein G; Guanine nucleotide-binding protein G(o) alpha 1
Type:
G protein, heterotrimeric; G protein
Mass (Da):
40051
Number AA:
354
UniProt ID:
P09471
International Prot ID:
IPI00220281
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0006936
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
G
C
T
L
S
A
E
E
R
A
Site 2
S6
_
_
M
G
C
T
L
S
A
E
E
R
A
A
L
Site 3
S29
N
L
K
E
D
G
I
S
A
A
K
D
V
K
L
Site 4
S44
L
L
L
G
A
G
E
S
G
K
S
T
I
V
K
Site 5
S47
G
A
G
E
S
G
K
S
T
I
V
K
Q
M
K
Site 6
T48
A
G
E
S
G
K
S
T
I
V
K
Q
M
K
I
Site 7
S62
I
I
H
E
D
G
F
S
G
E
D
V
K
Q
Y
Site 8
Y69
S
G
E
D
V
K
Q
Y
K
P
V
V
Y
S
N
Site 9
Y74
K
Q
Y
K
P
V
V
Y
S
N
T
I
Q
S
L
Site 10
S112
K
M
V
C
D
V
V
S
R
M
E
D
T
E
P
Site 11
T117
V
V
S
R
M
E
D
T
E
P
F
S
A
E
L
Site 12
S121
M
E
D
T
E
P
F
S
A
E
L
L
S
A
M
Site 13
Y147
C
F
N
R
S
R
E
Y
Q
L
N
D
S
A
K
Site 14
S152
R
E
Y
Q
L
N
D
S
A
K
Y
Y
L
D
S
Site 15
Y155
Q
L
N
D
S
A
K
Y
Y
L
D
S
L
D
R
Site 16
Y156
L
N
D
S
A
K
Y
Y
L
D
S
L
D
R
I
Site 17
S159
S
A
K
Y
Y
L
D
S
L
D
R
I
G
A
A
Site 18
Y168
D
R
I
G
A
A
D
Y
Q
P
T
E
Q
D
I
Site 19
T171
G
A
A
D
Y
Q
P
T
E
Q
D
I
L
R
T
Site 20
T182
I
L
R
T
R
V
K
T
T
G
I
V
E
T
H
Site 21
S207
F
D
V
G
G
Q
R
S
E
R
K
K
W
I
H
Site 22
T240
Q
V
L
H
E
D
E
T
T
N
R
M
H
E
S
Site 23
T241
V
L
H
E
D
E
T
T
N
R
M
H
E
S
L
Site 24
S247
T
T
N
R
M
H
E
S
L
M
L
F
D
S
I
Site 25
S282
F
G
E
K
I
K
K
S
P
L
T
I
C
F
P
Site 26
T285
K
I
K
K
S
P
L
T
I
C
F
P
E
Y
T
Site 27
Y291
L
T
I
C
F
P
E
Y
T
G
P
N
T
Y
E
Site 28
T296
P
E
Y
T
G
P
N
T
Y
E
D
A
A
A
Y
Site 29
S310
Y
I
Q
A
Q
F
E
S
K
N
R
S
P
N
K
Site 30
S314
Q
F
E
S
K
N
R
S
P
N
K
E
I
Y
C
Site 31
Y320
R
S
P
N
K
E
I
Y
C
H
M
T
C
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation